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Biomedical subjects

M A Frenkel'

Publications and source records attributed to M A Frenkel'.

At least 37 records · Page 2Linked to original sources
PubMed1989

[Late results of the treatment of acute granulocytic leukemia in adults].

Eighteen patients with acute granulocytic leukemia (MI-1, M2-10, M3-1 and M4-6) underwent AdOAP treatment. Complete remissions were achieved in 10 out of the 18 patients (55.6%), 3 patients proved resistant, 5 had died prior to recovery of normal hemopoiesis. Three lethal cases are attributed to the results of the therapy complications. Median duration of complete remissions reached 17.5 months. Two patients have been in remission over 3 years. Reduced duration or intensity of the induction therapy failed to diminish frequency of lethal complications due to progressive cytopenia.

Adolescent↗
PubMed1989

[Ph'-positive acute leukemia].

A comparative study of Ph'-positive and Ph'-negative blast cells of patients with acute leukemia (12 and 63, respectively) has revealed certain differences between them: Ph'-positive elements were more often characterized by a mixed immunological phenotype, they could grow in agar culture. The therapy of Ph'-positive leukemia was less effective than that of Ph'-negative disease.

Adolescent↗
PubMed1989

[Possibilities of the immunodiagnosis of erythroleukemia].

The authors describe 6 cases of acute leukemia in which erythroid antigens identified by monoclonal antibodies HAE-3 and HAE-9 (against glycophorin A and antigen of nuclear erythroid cells) were expressed on blasts. The morphocytochemical methods were employed to establish different varieties of leukemia according to the FAB-classification: 2-L1, 2-L2, 1-M2, and 1-M. In 4 cases, the existence of the markers of the early stages of differentiation was shown immunologically. Two patients demonstrated the mixed, variant of leukemia (erythroid-T-cellular and erythroid-myeloid). In 5 out of the 6 cases, the patients turned out refractory to chemotherapy. The lethal outcomes were recorded in the first acute period or in the stage of a relapse (one patient) after a very short 2-month remission.

Antibodies, Monoclonal↗
PubMed1988

[Dynamic immunological and cytochemical markers in the induced differentiation of the K-562 cell line].

The possibility of TPA-induced differentiation of K-562 cell line was studied. Monoclonal antibodies against differentiating antigens of HAE erythroid lineage and against myelomonocytic ICO lineage raised in the USSR Cancer Research Centre were used. Changes in immunological and cytochemical indexes suggest that K-562 cell differentiation goes in the erythroid direction. The cells lost early differentiation and acquired late differentiation markers.

Antibodies, Monoclonal↗
PubMed1987

[Phenotype of blast cells in acute lymphoblastic leukemia].

The complex morphocytochemical, immunological and cytogenetic investigation of the blast cells in acute lymphoblastic leukemia showed their considerable heterogeneity. There were several kinds of cells: typical blast cells, Ph'-positive blast cells expressing only Ia-like antigen and anaplastic blast cells with myeloid and erythroid differentiation.

Antigens, Neoplasm↗
PubMed1987

[Criteria for differentiated approaches to the therapy of lymphoblastic leukemia in adults].

The results of programmed therapy of acute lymphoblastic leukemia (ALL) in 31 adult patients were analyzed. Ph-positive ALL were marked in 5 patients. Low hemosuppressive induction, heavy consolidation and multidrug maintenance therapy was used. Complete remissions were obtained in 18 patients, their median time was 18 months (from 2 to 46 months). The patients were divided into groups with a good, intermediate and poor prognosis on the basis of an immunological ALL variant, the presence or absence of basal hyperleucocytosis and Ph-chromosome. Data on adequate therapy for each group were presented.

Adolescent↗
PubMed1987

[Morphofunctional characteristics of blasts in lymphoblastic leukemia and lymphoblastic lymphosarcoma].

The authors investigated morphocytochemical and immunological indices of blast cells of 81 patients with acute leukemia and 70 patients with lymphosarcoma at the stage of leukemization. Blast cells in acute leukemia were shown to have the phenotype of early hemopoietic precursors whereas in lymphosarcoma blasts were more differentiated. Morphologically in leukemia blasts were characterized by homogeneity, and in lymphosarcoma by considerable polymorphism and a higher mitotic activity.

Adult↗
PubMed1987

[Monoclonal antibodies to the antigen of myeloid cells].

ICO-G-2 hybridoma clone was obtained after fusion of spleen cells from BALB/c mice immunized with cells from a patient with acute myelomonoblastic leukemia (AMML) and P3 X 63 Ag8.653 cells, using 50% polyethyleneglycol, molecular weight 1500 KD. The antigen with a molecular weight of 100 KD was present only on polymorphonuclear neutrophils and eosinophils of the peripheral blood. The antigen expression was also found on the majority of myeloid precursors and some nuclear erythroid cells. CFU-GM did not express the antigen. Monoclonal antibodies ICO-G-2 reacted with blast cells of some patients with AML, AMML and CML. The antibodies did not react with cells from patients with AMonL, CMonL, ALL, CLL and LSA. Such pattern of reactivity makes these monoclonal antibodies useful for the differential diagnosis of acute nonlymphocytic leukemias and CML in blast crisis.

Animals↗
PubMed1986

[Morphofunctional characteristics of the blast cells in acute myelomonoblastic leukemia].

Morphocytochemical and immunological characteristics and indices of the cloning effectiveness were studied in agar cultures. Three types of leukemic cells were found whose ratio in the bone marrow varied in a rather wide range. The lymphoid markers (of cOLL and T-antigens) were detected on blast cells. It is established that histogenetic characteristics of the blast cells determines peculiarities of their growth in the agar culture.

Bone Marrow↗
PubMed1986

[Acute plasmablastic leukemia in multiple myeloma].

Five cases of acute plasmablastic leukemia (APL) in patients with a history of multiple myeloma (MM) are described. MM lasted from 3 months to 7 years. During APL, blast metaplasia in the bone marrow was detected in all the cases while in 3 patients it was found in the blood. The treatment ended in failure in 4 patients. The duration of APL in those patients did not exceed 6 months. In one of the patients, the duration of APL, in the presence of a partial remission, exceeded 19 months. The patient remains under observation.

Acute Disease↗
PubMed1985

[Block of NK cell activity by ICO-11 monoclonal antibodies].

Antigen expression determined by ICO-11 monoclonal antibodies was studied on leukemia cells from bone marrow, blood cells from patients with lymphoproliferative diseases and natural killer (NK) cells responsible for natural resistance. ICO-11 monoclonal antibodies were shown to recognize the antigen expressed on NK-cells, predecessors of T-cells (thymocytes), myelomonocytes (myeloblasts, monoblasts) and to block NK-cell activity.

Adolescent↗