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Biomedical subjects

M A Everett

Publications and source records attributed to M A Everett.

At least 37 records · Page 2Linked to original sources
PubMed1988

DERM/INFONET: a concept becomes a reality.

The DERMatology INFOrmation NETwork (DERM/INFONET) of the American Academy of Dermatology has become a reality. DERM/INFONET consists of a number of data bases providing information and educational programs for the dermatologist. Currently the components are: DERM/MLS (Medical Literature Search), DERM/RX (dermatologic therapy), DERM/USP (United States Pharmacopeia data base), DERM/ALLERGENS (Food and Drug Administration and Environmental Protection Agency Listings of allergens); Melanoma Prognosis Model; Electronic Mail; Bulletin Board; Meetings Calendar; ICD/CPT (International Classification of Diseases/Current Procedural Terminology) codes; AAD Membership/Committee Directories; and Dermatology Quiz. Additional data bases are planned. As audiovisual and alphanumeric communication systems evolve, newer opportunities for enhancing the DERM/INFONET Biomedical Communication Network will undoubtedly provide even greater opportunities for aiding the dermatologist in delivering state-of-the art management for their patients.

Computer Communication Networks↗
PubMed1987

Congenital pigmented and vascular lesions in newborn infants.

The incidence of congenital cutaneous lesions was ascertained by a single dermatologist in each of 830 sequential newborn infants over a 3-month period at the Oklahoma Teaching Hospitals. Lesions were observed in 57% of infants (77% of blacks and 49% of nonblacks). Vascular lesions were the most frequent, occurring in 44% of neonates. Pigmented lesions other than mongolian spots were observed in 15.8% of blacks and in 1.6% of whites. Clinical criteria do not readily distinguish nevus cell nevi from other pigmented lesions. Wood's light examination did not enhance the identification of congenital lesions. Inadequate examination of infants and marked underreporting of congenital lesions in newborn infants are widespread.

Black People↗
PubMed1984

Immunoperoxidase examination of cutaneous infiltrates of mycosis fungoides and large-plaque atrophic parapsoriasis with OKT10.

A monoclonal antibody (OKT10), which was developed recently, reacts with pro-thymocytes, T cell acute lymphoblastic leukemia (ALL) cells, cells in normal bone marrow (including plasma cells), and activated T cells. Tissues from patients with cutaneous T cell lymphoma were studied for the presence of OKT10-reactive cells with the use of an indirect immunoperoxidase technic. OKT10-reactive cells were identified in three of eight cases of mycosis fungoides, one of two cases of Sézary syndrome, with an equivocal reaction in one of ten cases of large-plaque parapsoriasis and in one of seven positive patch tests (allergic contact dermatitis). The biologic and possible clinical implications are discussed.

Antibodies, Monoclonal↗
PubMed1983

OKT 9 reactivity in mycosis fungoides and large plaque (atrophic) parapsoriasis.

A monoclonal antibody OKT 9 which detects a determinant expressed by a variety of proliferating cell types has been recently developed. This antibody was used in conjunction with the immunoperoxidase technique to study the cutaneous lymphoid infiltrates of nine patients with mycosis fungoides, one patient with lymphomatoid papulosis, two patients with Sézary syndrome, and ten patients with large plaque atrophic parapsoriasis (a condition which may terminate in overt mycosis fungoides.) OKT 9 reactive cells were identified in all cases of mycosis fungoides examined, in one case of lymphomatoid papulosis, one of two cases of Sézary syndrome, and one of ten cases of large plaque atrophic parapsoriasis. These results suggest that further studies using OKT 9 should be performed to assess whether OKT 9 reactivity may be used as a prognostic marker in cutaneous lymphomas and prelymphomas.

Antibodies, Monoclonal↗
PubMed1982

Identification of T cell in parapsoriasis infiltrates. Use of an anti-human T-cell serum and the immunoperoxidase technique.

"Parapsoriasis" is a term used to include a heterogeneous group of conditions, one variant of which, at least, eventuates in mycosis fungoides in a substantial percentage of cases. The T-cell origin of mycosis fungoides is well established. The lack of similar information on lymphoid cell types in parapsoriasis prompted an immunoperoxidase study using a specific antihuman T-cell serum in a group of seven patients with parapsoriasis. Our findings demonstrated a preponderantly T-cell infiltrate in the categories of parapsoriasis examined.

Adult↗
PubMed1982

In situ demonstration of T cell subsets in atrophic parapsoriasis.

It has been demonstrated recently in mycosis fungoides and lichen planus that T lymphocyte subsets may be identified in cutaneous lymphocytic infiltrates using the immunoperoxidase technic in conjunction with monoclonal antibodies produced by the technic of Kohler and Milstein. This communication describes the application of this technic to cutaneous lymphoid infiltrates of parapsoriasis in which T cell predominance has been demonstrated previously. The lymphoid infiltrates of six patients with atrophic parapsoriasis were examined by the indirect immunoperoxidase technic using monoclonal antibodies (from two commercial sources) directed against "helper" and "suppressor" T cell subsets. Both "helper" and "suppressor" cells (as defined by a positive reaction with monoclonal antibodies) could be identified in cutaneous infiltrates. "Helper" cells predominated, but in varying degrees among patients. The relevance of these findings in relation to the possible development of clinical mycosis fungoides from atrophic parapsoriasis is discussed. In addition, factors causing difficulty in the consistent identification of cell subtypes are discussed. These factors suggest that in the present state of imperfection, difficulty will be experienced in using this technic for the accurate quantification of percentages of lymphocyte subsets in tissue sections.U

Antibodies, Monoclonal↗
PubMed1982

Demonstration of OKT 6-reactive cells in mycosis fungoides.

Infiltrates of five cases of mycosis fungoides (MF) were studied for the presence of cells reactive with a monoclonal antibody, OKT 6, which detects an antigen present on relatively immature thymocytes and Langerhans cells. In situ immunohistochemical staining was used for their demonstration. OKT 6-reactive cells formed a definite component of the dermal infiltrates of all patients examined. In three patients who showed numerous Pautrier microabscesses on routine histologic examination, OKT 6-positive cells were found to form a component of these abscesses. OKT 6-reactive cells have also recently been shown to be present in varying numbers in the dermal infiltrates of large plaque (atrophic) parapsoriasis (LPAP), a condition which may terminate in MF. The significance of these findings is discussed.

Antibodies, Monoclonal↗
PubMed1982

In situ immunologic phenotyping of mycosis fungoides.

In situ immunologic phenotyping of the cutaneous lymphoid infiltrates of five cases of mycosis fungoides (MF) was performed. This was done by the immunoperoxidase technic using monoclonal antibodies directed against normally expressed by mature peripheral T cells and T cells subsets. A significant proportion of the infiltrates reacted with peripheral T cell antibodies. In addition, "helper" predominance was demonstrated. However, cells reacting positively with "suppressor" antibodies were also demonstrated in three cases, indicating immunologic heterogeneity of the infiltrates. The presence of a significant component of the infiltrates yielding an equivocal or negative reaction with the mature T cell antibodies, especially in the infiltrates of one case which had a fatal outcome, suggests further heterogeneity with the presence of immature cells. Future investigation with monoclonal antibodies directed against immature T cell differentiation antigens will be of interest.

Antibodies, Monoclonal↗
PubMed1982

The immunohistochemical localization of lysozyme in human axillary apocrine glands.

Lysozyme has been observed in intraluminal secretory products of apocrine glands in specimens of normal human axillary skin. Lysozyme was also observed in an occasional apocrine secretory cell, as well as in leukocytes within vascular lumina and dermal histiocytes. Lysozyme was not observed in sebaceous glands, eccrine glands, or cells of the epidermis. These observations support an epithelial origin of cutaneous lysozyme and suggest a means of further characterization of the origin and/or differentiation of tumors of appendageal origin.

Adult↗
PubMed1982

OKT 6-positive cells: their demonstration in human thymus, and the effect of fixation on the immunoperoxidase reaction.

Human thymocytes at an intermediate stage of differentiation were demonstrated in situ in tissue sections of thymus using the mouse monoclonal antibody OKT 6 THY (Ortho Immunobiology Ltd, Raritan, NJ) and the immunoperoxidase technique. These cells were found to reside mainly within the thymic cortex. The effects of on-slide fixation on the ease of demonstration of the antigen involved were assessed. The choice of fixative was found to have a marked effect, acetone and paraformaldehyde producing the most satisfactory results.

Antibodies, Monoclonal↗