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Biomedical subjects

M A Evenson

Publications and source records attributed to M A Evenson.

39 records · Page 3Linked to original sources
PubMedDate not supplied

A SepPak HPLC method for tricyclic antidepressant drugs in human vitreous humor.

Death from tricyclic antidepressant overdose has become an all-too-common occurrence. Several factors, including postmortem concentration changes, can render blood and tissue samples useless for the determination of antidepressant drug concentrations. We present here an efficient method of solid-phase extraction for these drugs from vitreous humor and a reversed-phase, isocratic high-performance liquid chromatographic method for the simultaneous quantitation of amitriptyline, doxepin, and imipramine and their desmethylated metabolites.

Amitriptyline↗
PubMedDate not supplied

Isolation and properties of human alpha-fetoprotein from HepG2 cell cultures.

A relatively rapid 3-step fractionation method has been developed for the isolation of human alpha-fetoprotein from culture fluids of HepG2 cells applicable to large volumes. The protein exists as a complex with lipids or lipoproteins but an ethanol precipitation step is effective in separating it. Yields of 50-60% can be obtained from culture fluid containing 30-40 microg/ml. A minor fraction that appears to be a proteolytic product of the AFP is present in the final product.

Humans↗