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Biomedical subjects

M A Cooper

Publications and source records attributed to M A Cooper.

99 records · Page 6Linked to original sources
PubMed1980

Urinary and caudate nuclei catecholamine levels in stress-susceptible and normal swine.

Eight stress-susceptible and eight normal pigs were used in the first portion of the study. Urine samples were collected for 24 hr over 4 consecutive days while the pigs were kept in metabolism cages. Each 24-hr sample was assayed for epinephrine, norepinephrine and dopamine. Urinary levels of dopamine were lower (P < .01) in the stress-susceptible pigs. No significant differences in urinary epinephrine or norepinephrine were observed. The second portion of the study evaluated the catecholamines in the caudate nucleus of the brain. Six stress-susceptible and six control pigs were examined. Immediately after exsanguination, caudate nuclei were excised and frozen in liquid nitrogen. The caudate nuclei were assayed for catecholamines within 2 to 3 days of freezing. Caudate nuclei dopamine levels were lower (P < .01) in stress-susceptible pigs (5,961 ng/g) than in control pigs (10,878 ng/g). No significant differences in norepinephrine levels of the caudate nuclei were observed between the two groups.

Animals↗
PubMed1974

Antibody levels in human sera measured by the fluorescent-antibody technique against the coxsackie B viruses types 1-5 grown in HEp2 cells compared with results obtained by neutralization.

Twenty pairs of acute and convalescent sera were tested for antibody to the coxsackie B viruses types 1-5 by neutralization and fluorescent-antibody techniques. Results by fluorescence were difficult to read and sensitivity was therefore reduced. Rises by neutralization were type specific in the majority of cases, while those by fluorescence were always against more than one viral type.

Acute Disease↗
PubMedDate not supplied

Fatal leukemia in interleukin-15 transgenic mice.

The role of inflammation in the early genesis of certain malignancies has recently been appreciated. Interleukin (IL)-15, a proinflammatory cytokine and growth factor, is required for lymphocyte homeostasis. Intriguingly, the expression of IL-15 protein is tightly controlled by multiple posttranscriptional mechanisms, suggesting that inappropriate expression of IL-15 may be detrimental to the host. We recently engineered a transgenic mouse in which the normal posttranscriptional control of IL-15 is eliminated, thereby overexpressing the murine IL-15 protein. IL-15 transgenic mice have early expansions in NK and CD8+ T lymphocytes and later develop fatal lymphocytic leukemia with a T-NK phenotype. This article recapitulates the phenotype of these IL-15 transgenic mice and discusses the utility of this model as a tool to further our understanding of leukemogenesis.

Animals↗
PubMedDate not supplied

Deliberate self-harm in children: the nurse's therapeutic style.

This article examines child health nursing skills in the management of deliberate self-harm in children and young people. In order for education to be effective (i.e. so that it changes practice) it must address the belief systems of the practitioner. It is suggested that such belief systems are embedded in collectively held tribal stories. The more challenging the patient's behaviour, the more powerful the influence of the tribal narrative--possibly as a defensive strategy. The authors outline strategies aimed at increasing the range and depth of the therapeutic response to episodes of self-harm, and outline nursing interventions in the management of self-harming children.

Attitude of Health Personnel↗
PubMedDate not supplied

The use of granulocyte colony-stimulating factor in the treatment of fever and neutropenia in a heart transplant patient.

We had the opportunity to study the clinical effects of granulocyte colony-stimulating factor in a heart transplant patient with a classic febrile neutropenic episode that was thought to be caused by immunosuppressive therapy. Administration of granulocyte colony-stimulating factor resulted in rapid recovery of his absolute neutrophil count, with resolution of fevers. Endomyocardial biopsy showed no pathologic evidence of worsened rejection. The use of hematopoietic cytokines after the organ allograft requires further study before it can be routinely advocated in this patient population.

Adult↗