Search PubMed⌕ Search

Biomedical subjects

Lucjan Pawlicki

Publications and source records attributed to Lucjan Pawlicki.

15 recordsLinked to original sources
PubMed2006

N-terminal brain natriuretic propeptide levels correlate with procalcitonin and C-reactive protein levels in septic patients.

The aim of this study was to find the relationship between N-terminal brain natriuretic propeptide (NT-proBNP), procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations in septic patients. This was a prospective study, performed at Medical University Hospital No. 5 in łódź. Twenty patients with sepsis and severe sepsis were included in the study. N-terminal brain natriuretic propeptide, procalcitonin and C-reactive protein concentrations, and survival were evaluated. In the whole studied group (128 measurements), the mean NT-proBNP, procalcitonin and C-reactive protein concentrations were, respectively: 140.80+/-84.65 pg/ml, 22.32+/-97.41 ng/ml, 128.51+/-79.05 mg/l. The correlations for the NT-proBNP level and procalcitonin and C-reactive protein levels were 0.3273 (p<0.001) and 0.4134 (p<0.001), respectively. NT-proBNP levels correlate with PCT and CRP levels in septic patients. In the survivor subgroup, the mean NT-proBNP plasma concentrations were significantly lower than in the non-survivor subgroup.

Adult↗
PubMed2006

Neutrophil superoxide anion generation during atorvastatin and fluvastatin therapy used in coronary heart disease primary prevention.

Neutrophil superoxide anion generation was measured during atorvastatin and fluvastatin therapy in patients with coronary heart disease (CHD) risk. The patients were randomly allotted into three groups. The atorvastatin group comprised 17 patients who were administered the drug orally 10 mg a day at bed time. The fluvastatin group consisted of 18 patients on an oral dose of 40 mg once daily at bed time. The control group comprised 12 healthy subjects with no drug administration. Blood samples were collected from cubital vein before and after 6-week therapy with these drugs and once in the control group. Neutrophil superoxide anion generation in whole blood without and with opsonized zymosan (OZ) stimulation was determined using superoxide dismutase from bovine erythrocytes. In the atorvastatin group, statistically significant (P < 0.05) decrease in superoxide anion generation by nonstimulated and OZ-stimulated neutrophils was observed after 6 weeks of therapy. In fluvastatin group, no changes in neutrophil superoxide anion generation were observed after the 6-week treatment period. Our study has shown an additional nonlipid mechanism of atorvastatin used in CHD primary prevention.

Adult↗
PubMed2006

NT-proBNP levels correlate with organ failure in septic patients: a preliminary report.

UNLABELLED: The aim of the study was to evaluate the relationship between N-terminal brain natriuretic propeptide (NT-proBNP) plasma concentrations and the severity of organ dysfunction assessed by the Sepsis-related Organ Failure Assessment (SOFA) score in septic patients MATERIAL/METHODS: NT-proBNP, SOFA score, and survival were evaluated in 20 consecutive septic patients. They were prospectively included in the study when the sepsis criteria according to the ACCP/SCCM definitions (modified by the Polish Working Group for Sepsis) were fulfilled. Blood serum NT-proBNP concentrations were determined in each patient at given time intervals and the severity of organ dysfunction was estimated according to the SOFA score. The first measurement was performed within 12 h after the patient's inclusion into the study, the second, third, and fourth at 12, 24, and 48 hours after the first, and then every 48 hours thereafter RESULTS: The mean NT-proBNP concentration and the mean SOFA score were 140.80+/-84.65 pg/ml and 6.31+/-3.75 points, respectively. The correlation coefficient between NT-proBNP level and SOFA score was R=0.5164 (p<0.05). The mortality in the studied group was 30%. CONCLUSIONS: NT-proBNP levels correlate with the severity of organ dysfunction as assessed by the SOFA score in septic patients.

Adult↗
PubMed2005

Neutrophils superoxide anion generation during carvedilol therapy in patients with stable angina.

Neutrophil superoxide anion (O(2)(*-)) generation was measured during carvedilol therapy in patients with stable angina. The carvedilol group comprised 27 patients (18 men and 9 women), aged 38-51 years (mean 47.6 years) with stable angina. Carvedilol was administered in increased every 4-week doses: 12.5, 25 and 50 mg/24 h, respectively. The control group included 12 healthy subjects, aged 39-49 years (mean 45.7 years) with no drug administered. Blood samples were collected from cubital vein before and 4, 8 and 12 weeks after the therapy and once in the control group. Neutrophil O(2)(*-) generation was determined in whole blood without and with opsonized zymosan (OZ) stimulation according to Bellavite et al. method using superoxide dismutase from bovine erythrocytes. O(2)(*-) generation by nonstimulated and OZ-stimulated neutrophils was significantly higher (p<0.05) in patients with stable angina than in the control group. In carvedilol group, statistically significant (p<0.05) decrease in superoxide anion generation by nonstimulated and OZ-stimulated neutrophils was observed 8 and 12 weeks after the therapy and it did not differ from that in healthy subjects. Carvedilol has been shown to inhibit neutrophil O(2)(*-) generation in patients with stable angina.

Adult↗
PubMed2005

[Estimation of antioxidative effect of atorvastatin and fluvastatin used in primary prevention of coronary heart disease--effect on antioxidative enzymatic activity].

The effect of atorvastatin and fluvastatin on antioxidative enzymatic activity was studied in CHD risk patients. The study comprised 35 patients (20 men and 15 women) aged 35-47 years, who were allotted into two groups: I--18 patients were administered fluvastatin (Lescol) in a dose of 40 mg once daily at bed time for 6 weeks and II--17 patients were administered atorvastatin (Sortis) in a dose of 10 mg once daily at bed time for 6 weeks. The control group consisted of 12 clinically healthy subjects, aged 34-42 years. SOD-1, GSH-Px and CAT activity in erythrocytes was measured. Greater increase of low erythrocyte antioxidative enzymatic activity was observed in atorvastatin than in fluvastatin group.

Adult↗
PubMed2005

[Assessment of oral cavity mucosa and teeth state in patients with chronic obstructive pulmonary disease--part I].

UNLABELLED: The aim of the study was to assess the state of oral cavity mucosa and teeth in patients with chronic obturative pulmonary disease (COPD). MATERIAL AND METHODS: The study comprised 100 patients with COPD (68 men and 32 women), aged 30-83 years (mean 63.1 +/- 10.17 years). All patients demonstrated II grade COPD (moderate COPD). FEV1/FVC<70% and FEV1 was within 79% and 50% of the predicted value. Beta2-adrenomimetic inhalants or in nebulization, theophylline were applied in the therapy. The control group consisted of 101 subjects (38 men and 63 women), aged 42-88 years (mean 65.3-10.36 years), with no respiratory tract ailments. The rate of smoking was similar in both groups. The examination of oral cavity mucosa and teeth state was performed in artificial lightening with the use of probe and mouth mirror. The number of lacking teeth and the advancement of caries were determined. RESULTS: Thrush appeared to be the most frequent oral cavity mucosa ailment in COPD patients. Toothlessness and reduced teeth number were observed significantly more often in COPD patients than in the control group (p<0.05). The frequency and the type of caries did not differ significantly between the two groups (p>0.05).

Adult↗
PubMed2005

[Assessment of periodontal state in patients with chronic obstructive pulmonary disease--part II].

UNLABELLED: The aim of the study was to estimate the periodontal state in chronic obstructive pulmonary disease (COPD). MATERIAL AND METHODS: The study comprised 100 patients with COPD (68 men and 32 women), aged 30-83 years (mean 63.1 +/- 10.17 years). All patients were in the II grade COPD (moderate COPD). FEV1/FVC<70% and FEV1 was within 79% and 50% of the predicted value. Beta2-adrenomimetic inhalants or in nebulization, theophylline were applied in the therapy. The control group consisted of 101 subjects (38 men and 63 women), aged 42-88 years (mean 65.3-10.36 years), with no respiratory tract diseases. The rate of smoking was similar in both groups. To examine periodontal state, periodontal pocket depth was measured (with periodontal sound), Periodontal Index (PI) and dental plaque index were assessed. RESULTS: The frequency and severity of periodontal diseases in COPD patients were demonstrated to be significantly increased as compared to the control group (p<0.05). Adult chronic periodontitis (ACP) was observed significantly more frequently in COPD patients (84.21%) than in the control group (59.74%, p<0.05). A positive correlation was found between periodontal pocket depth and dental plaque index in patients with COPD. CONCLUSION: The frequency and intensification of periodontal diseases speak for their cause-and-effect relationship with COPD. The prophylaxis and treatment of periodontal diseases should be of great importance in the COPD therapy, which may increase its effectiveness.

Adult↗
PubMed2005

[Estimation of antioxidative effect of atorvastatin and fluvastatin used in primary prevention of coronary heart disease--effect on lipid peroxidation].

The study comprised 35 patients with mixed hyperlipidaemia and coronary heart disease (CHD) risk factors (overweight or obesity, low physical activity, family history). Seventeen patients were administered atorvastatin in a dose of 10 mg and 18 -fluvastatin in a dose of 40 mg once daily at bed time for 6 weeks. The control group consisted of 12 clinically healthy subjects with no CHD risk factors. Blood samples for testing were collected from cubital vein of patients after hypolipaemic diet prior to and 6 weeks after drugs application and once in control group. Malondialdehyde (MDA) concentrations in erythrocytes and plasma were determined by the method of Placer et al. MDA concentrations in erythrocytes and plasma were significantly higher (p < 0.05) in patients than in healthy subjects. After 6-week atorvastatin therapy MDA concentrations in erythrocytes and plasma decreased to the values observed in healthy subjects. In fluvastatin group erythrocyte and plasma MDA concentrations were unchanged and still significantly higher in comparison to the healthy subjects. Atorvastatin, contrary to fluvastatin, decreases lipid peroxidation in CHD risk patients.

Adult↗
PubMed2005

[Risk factors and coronary heart disease prevention in selected Lódź population--Part I].

UNLABELLED: Cardiovascular diseases are one the main causes of mortality all over world. Proper estimation and reduction of atherosclerosis risk factors are very important in both primary and secondary prevention of coronary heart disease (CHD). THE AIM: of our study was to estimate atherosclerosis risk factors profile in subjects, inhabitants of Lódź (Poland), with (group I) and without (group II) CHD. MATERIAL AND METHODS: Group I--196 patients (85 men and 111 women), aged 34-88 years (mean 63.3 +/- 10.1 years). Group II--170 subjects (87 men and 83 women), aged 24-82 years (mean 58.16 +/- 13.8 years) without CHD. RESULTS: Overweight or obesity was the most frequent CHD risk factor in the examined population (74.49% in group I). Other risk factor in this group were: increased total cholesterol level (65.08%), hypertension (51,53%), smoking (40.31%), diabetes (24.08%). In group II overweight or obesity was observed in 60% patients, smoking--48.82%, elevated total cholesterol level--43.53%, hypertension--40.24% and diabetes--16.98%. CONCLUSION: Our study have demonstrated that realisation of primary and secondary prevention principles in Lódź population is insufficient.

Adult↗
PubMed2005

[Risk factors and coronary heart disease prevention in selected Lódź population--part II].

THE AIM: Evaluation of the knowledge on CHD risk factors in selected Lódź population was made. MATERIAL AND METHODS: Realization of primary and secondary CHD prevention principles was assessed. RESULTS: Over 20% of patients with CHD and over 38% of subjects without CHD did not realize the prevention principles. Hypolipemic therapy was effective only in 44.21% of patients with CHD and 35.9% of subjects without CHD. Antihypertensive therapy was successful in about 55% of patients with CHD and 35% of subjects without CHD. CONCLUSION: The results of our study have shown low effectiveness of both CHD prevention principles realization and hipolipemic and antihypertensive therapy in selected Lódź population.

Adult↗
PubMed2004

Plasma antioxidative activity during atorvastatin and fluvastatin therapy used in coronary heart disease primary prevention.

We estimated the effect of atorvastatin and fluvastatin on plasma antioxidative activity used in coronary heart disease (CHD) primary prevention. Anti-oxidative activity of blood plasma was determined by Bartosz et al. method [Curr. Top. Biophys. (1998)22:11-13], based on reduction of preformed cation radical of 2,2,azinobis(3-ethylbenzothiazoline-6-sulphonic acid) by blood plasma. The study comprised 35 patients with CHD risk who were randomly divided into two groups. The atorvastatin group comprised 17 patients who were administered the drug orally in a daily dose of 10 mg and the fluvastatin group consisted of 18 patients on an oral dose of 40 mg once daily. The control group comprised 12 healthy subjects with no drug administration. Blood samples were collected from cubital vein before and after 6-week therapy. Significantly (P < 0.05) increased--in comparison with the initial values--antioxidative activity of blood plasma was found in atorvastatin and fluvastatin groups after 6-week therapy. Moreover, the increase in antioxidative plasma activity in atorvastatin group was significantly higher in comparison with the fluvastatin group. The results of our study have demonstrated that atorvastatin and fluvastatin have an additional mechanism independent of the effect on cholesterol concentration. Thus, we presume that administration of these statins in CHD risk patients may have a beneficial effect.

Adult↗
PubMed2004

[Plasma antioxidative activity in patients with pulmonary tuberculosis].

Plasma antioxidative activity was determined by spectrophotometric method by estimation of plasma volume resulting in inhibition of free radical reaction rate by 50%. The study comprised 40 patients with pulmonary tuberculosis (25 men, 15 women) aged 19-77 years (mean 48.5). Every patient had infiltrative pulmonary tuberculosis diagnosed. After 1-month therapy with tuberculostatic drugs vitamins C and E were added in 15 patients in a daily dose of 1.0 g and 600 mg respectively. The control group consisted of 16 clinically healthy subjects (12 men, 4 women) aged 28-57 years (mean 42.5). Decrease in plasma antioxidative activity was found in patients as compared to the controls before as well as after therapy with tuberculostatic drugs. However, in patients with added vitamins (after 1-month tuberculostatic therapy) increase in plasma antioxidant activity was observed.

Adult↗
PubMed2004

[Transthoracic fine-needle lung biopsy with linear transducer and bioptic channel monitored ultrasonographically].

From 1999 to 2002 81 transthoracic fine-needle lung biopsies (TFNB) were performed with use of linear transducer (3.5 MHz) and bioptic channel, monitored ultrasonographically. The procedure was applied in 70 patients with peripheral lesions on chest X-ray or CT, which needed histopathological examination. Our study showed that linear transducer with bioptic channel is useful in monitoring needle path and material aspiration during transthoracic fine-needle biopsy. Application of this equipment makes the procedure safe for patients and the percentage of observed complications is low. Specificity and sensitivity of the procedure is comparable to other imaging techniques.

Aged↗
PubMed2003

[LDL-receptors expression on peripheral blood monocytes in various clinical types of atherosclerosis, depending on LDL concentration in serum].

In our studies an attempt was undertaken to establish whether there is a relationship between total cholesterol and LDL fraction concentrations and LDL receptors expression on monocytes in various clinical types of atherosclerosis and in subjects without clinical manifestations of this disease before and after 40 years of age. The study included 77 subjects divided into 4 groups: I--after myocardial infarction, II--after cerebral ischaemic stroke, III--with obliterative atheromatosis of the lower limbs, and control group IV without clinical symptoms of atheromatosis: a) subjects below 40 years of age b) over 40 years of age. Receptor expression on monocytes was tested with LDL Receptor Test (Orpegen Pharma, Heidelberg, Germany) using flow fluorometry method (FAC Scan, Backton Dickinson, San Jose, USA). The value of LDL receptors expression was calculated based on the difference of mean fluorescence intensity of monocytes incubated in low-lipid (LPDS) and autologous sera. It has been demonstrated that particular types of atheromatosis vary in the value of total cholesterol and LDL fraction concentrations. The highest concentrations of these lipid fractions were observes in ischaemic heart disease and only in this group they correlated with the value of LDL receptors expression on monocytes. This observation suggests that various clinical types of atheromathosis may differ pathogenically and lesions in the vessels may be the consequence of cholesterol transport defect or of lipid molecule modification; they not necessarily depend on the value of absolute lipid concentration in blood.

Adult↗