Biomedical subjects

Louis G Keith

Publications and source records attributed to Louis G Keith.

39 records · Page 3Linked to original sources

PubMedDate not supplied

Does hormonal replacement therapy actually protect against cardiovascular disease?

It is generally accepted that menopausal symptoms can be controlled by HRT. As additional (putative) benefits of HRT were discovered, it was claimed that such uses were also important. Soon, trials were instituted to test these assertions, some of them quite large and projected to last a long time (> or = 5 years). The most instructive for medical practice are the observational trials and, still more, randomized, controlled trials. Unfortunately, the results of these trials for both primary and secondary prevention of CHD are not in agreement, although the observational trials are mostly more favorable to the benefits of HRT on CHD. The present review considers both kinds of trials and their effects on primary and secondary CHD prevention. It also attempts to group the studies by their results and their implications for guiding patients in choices and decisions regarding HRT.

Cardiovascular Diseases↗

PubMedDate not supplied

Defining the high-risk nature of triplet pregnancies.

Triplet pregnancies are by nature rare. Assisted reproductive technologies have multiplied their rate of occurrence in the last two decades. Whether spontaneous or induced, triplet pregnancies present obstetric and neonatal-and then often lifelong-medical problems severalfold more often than singletons, or even twins. The major cause of problems for triplet gestations stems from preterm delivery and low birth weight.

Birth Weight↗

PubMedDate not supplied

Screening and diagnostic mammograms: why the gold standard does not shine more brightly.

The objective of this article was to evaluate the sensitivity, specificity, positive predictive value, and negative predictive value of both screening and diagnostic mammograms. We looked at twenty seven studies found online with keywords: mammography, positive predictive value, negative predictive value, sensitivity, and specificity using the search engines google.com and botbot.com and placed them into three tables, sorting them first by purpose: either screening or diagnostic studies, and then by study size. We found a wide range of values in the studies reported and a high rate of false positives in many of them as well. Although many clinicians use the mammogram so often and rely on those results, many would benefit by being able to see the wide range of data that is reported worldwide in a format as shown in this article.

Breast Neoplasms↗