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Biomedical subjects

Lewis Wolpert

Publications and source records attributed to Lewis Wolpert.

10 recordsLinked to original sources

Causal belief and the origins of technology.

The primary function of the brain is to control movement. Human interactions with the environment, unlike those of other primates, are based on a belief in cause and effect, and this led to technology. Experiments requiring simple manipulations of the environment show that chimpanzees do not have concepts of causes or forces. Children, by contrast, have causal beliefs as a developmental primitive, and these can be demonstrated even in infants. It is proposed that the evolution of causal thinking was essential for the development of tool use, as it is not possible to make a complex tool without understanding cause and effect. This was a great evolutionary adaptive advantage. The evolution of language may have been linked to the same process. It has been technology that resulted from causal beliefs, not social interaction, that has driven human evolution.

Adaptation, Physiological↗

Lewis Wolpert.

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Engineering↗

Left-right asymmetry: all hands to the pump.

How do embryos establish differences between their left and right sides? Previous studies have implicated various signaling molecules and directional beating of cilia. Now, a new player enters the scene: the proton-potassium pump.

Animals↗

The progress zone model for specifying positional information.

The Progress Zone Model proposes that positional information in a growing system can be specified by the time the cells spend in a zone where growth occurs. In the vertebrate limb, the Progress Zone is specified by the Apical Ectodermal Ridge. The best evidence for the model is that killing cells in the zone at an early stage leads to loss of proximal structure as cells remain much longer in the zone as it becomes repopulated.

Animals↗