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Biomedical subjects

Lawrence M White

Publications and source records attributed to Lawrence M White.

27 records · Page 2Linked to original sources
PubMed2003

Low-grade liposarcoma with osteosarcomatous dedifferentiation: radiological and histological features.

We describe the radiological and pathological findings of a rare case of a low-grade liposarcoma associated with a high-grade osteosarcomatous component in a 78-year-old woman. Pre-operative imaging demonstrated a well-encapsulated homogeneous fatty tumour in the right buttock deep to the gluteal musculature. Centrally within the fatty tumour a region of increased soft tissue attenuation on CT and heterogeneous high signal on fat-saturated T2-weighted MRI was seen with amorphous calcification/ossification. Histological assessment revealed a low-grade liposarcoma containing an area of dedifferentiation that resembled an osteosarcoma. We describe the radiological-pathological findings in this rarely reported clinical entity and discuss the differential diagnosis of calcification within lipomatous tumours.

Aged↗
PubMed2003

MR imaging of cartilage repair procedures.

It is becoming increasingly important for the radiologist to evaluate the appearance and outcome of cartilage repair procedures. MR imaging is currently the best method for such evaluation but it is necessary to use cartilage-specific sequences and to modify those sequences when necessary to minimize artifacts from retained metal within the joint. This article reviews the surgical technique of the more commonly performed cartilage repair procedures, currently recommended techniques for the MR imaging evaluation of articular cartilage and cartilage repair procedures, and the MR imaging appearance of cartilage repair procedures and of the most frequently encountered complications following such procedures.

Arthroplasty↗
PubMed2003

Osseous invasion by soft-tissue sarcoma: assessment with MR imaging.

PURPOSE: To assess magnetic resonance (MR) imaging signs and overall accuracy of MR imaging for detection of osseous invasion by soft-tissue sarcoma, with histopathologic correlation as the reference standard. MATERIALS AND METHODS: Preoperative MR images (1.5 T, transverse and longitudinal planes, T1 and T2 weighted) of 56 osseous sites in 51 patients who underwent bone resection at surgery for soft-tissue sarcoma were assessed retrospectively for signs of osseous invasion, by consensus of two readers who were blinded to clinical and histopathologic findings. Delay between MR imaging and surgery averaged 34 days (range, 2-112 days). MR signs assessed included osseous abutment by tumor, maximal diameter of osseous abutment, extent of circumferential abutment of long bones (<25%, 25%-50%, >50%), cortical destruction, and cortical and medullary signal intensity change on T1- and T2-weighted images. Imaging findings were correlated with histopathologic findings. Sensitivities, specificities, positive and negative predictive values (PPV, NPV), and P values were calculated. RESULTS: Eleven sites (20%) showed osseous invasion histologically (two, cortical; nine, both cortical and medullary). Tumor abutted bone at 44 lesion sites (sensitivity, 100%; specificity, 27%). Maximal diameter of osseous abutment and extent of circumferential abutment did not significantly affect osseous invasion (P =.09 and.11, respectively). On T1- and T2-weighted images, 13 lesion sites showed cortical signal intensity change (sensitivity, 100%; specificity, 96%) and 10 showed cortical destruction (sensitivity, 82%; specificity, 98%). Eleven sites showed decreased medullary T1 signal intensity (sensitivity, 100%; specificity, 96%), and 12 showed increased medullary T2 signal intensity (sensitivity, 100%; specificity, 94%). MR imaging overall had a sensitivity of 100%, specificity of 93%, PPV of 79%, and NPV of 100% for detection of osseous invasion on the basis of any finding of cortical destruction or cortical or medullary signal intensity change on T1- or T2-weighted images (P <.001). CONCLUSION: On T1- and T2-weighted MR images, findings of cortical and medullary signal intensity change and cortical destruction were sensitive and specific for detection of osseous invasion by soft-tissue sarcoma.

Adolescent↗
PubMed2002

Technical considerations: CT and MR imaging in the postoperative orthopedic patient.

Cross-sectional imaging utilizing computed tomography (CT) and magnetic resonance (MR) imaging have become routine components in the imaging assessment of patients with musculoskeletal disease. Unfortunately, in the setting of a postoperative orthopedic patient with associated orthopedic metallic instrumentation, these imaging techniques are prone to artifacts resulting in image quality degradation. An understanding of the physical basis of such metal-related artifacts, and their appearance on CT and MR imaging, has led investigators to the implementation of a series of techniques and modifications to imaging protocols to decrease CT and MR imaging artifacts in the vicinity of metallic instrumentation. Utilizing such modified imaging techniques, consistent, improved CT and MR image quality may be achieved in imaging of the postoperative orthopedic patient.

Artifacts↗
PubMed2002

Diagnosis of recurrent meniscal tears: prospective evaluation of conventional MR imaging, indirect MR arthrography, and direct MR arthrography.

PURPOSE: To prospectively investigate the accuracy of conventional magnetic resonance (MR) imaging, direct MR arthrography, and indirect MR arthrography in assessment of possible recurrent or residual meniscal tears. MATERIALS AND METHODS: Three hundred sixty-four patients who had previously undergone meniscal preservation surgery were prospectively examined with conventional MR imaging, indirect MR arthrography, and direct MR arthrography. Ninety-four patients (104 postoperative menisci) underwent subsequent second-look arthroscopic surgery. Each case was evaluated for (a) surfacing intrameniscal intermediate- or T1-weighted signal intensity, (b) surfacing intrameniscal T2-weighted signal intensity, (c) morphologic changes beyond those expected postoperatively, (d) joint effusion on conventional MR or indirect MR arthrographic studies, and (e) overall presence or absence of recurrent meniscal tear. RESULTS: Seventy-one arthroscopically proved recurrent meniscal tears were found. In the diagnosis of recurrent meniscal tears, sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 86%, 67%, 83%, 71%, and 80%, respectively, for conventional MR imaging; 83%, 78%, 90%, 64%, and 81%, respectively, for indirect MR arthrography; and 90%, 78%, 90%, 78%, and 85%, respectively, for direct MR arthrography. No significant difference in the diagnostic accuracy of one method relative to another was observed (P >.54). Surfacing intrameniscal T2-weighted signal intensity was the most specific sign, with the highest positive predictive value of a recurrent tear. CONCLUSION: Although a small incremental increase in accuracy is associated with the use of direct MR arthrography over conventional MR imaging and indirect MR arthrography, no significant difference in diagnostic accuracy among the three techniques was demonstrated for detection of recurrent or residual meniscal tear.

Adolescent↗
PubMed2002

Acute lateral patellar dislocation at MR imaging: injury patterns of medial patellar soft-tissue restraints and osteochondral injuries of the inferomedial patella.

PURPOSE: To assess magnetic resonance (MR) imaging findings after acute lateral patellar dislocation (LPD) with emphasis on the medial patella restraints and to describe a medial patellar impaction deformity. MATERIALS AND METHODS: Knee MR images obtained within 8 weeks after LPD were evaluated for medial retinacular and medial patellofemoral ligament (MPFL) disruption, vastus medialis obliquus (VMO) edema and/or elevation, and other derangements. One hundred patients with no evidence of prior LPD were evaluated as controls. The Student t test was used for statistical comparisons. RESULTS: Eighty-two examinations were performed in 81 patients with LPD (mean age, 20 years; age range, 9-57 years). Seventy-six percent (62 of 82 examinations) showed medial retinacular disruption at its patellar insertion; 30% (25 of 82), at its midsubstance. The MPFL femoral origin was identified in 87% (71 of 82); of these, 49% (35 of 71) showed injury. Forty-eight percent (39 of 82) showed more than one site of injury to the medial stabilizers; 45% (37 of 82) showed edema or hemorrhage at the inferior VMO. Mean VMO elevation in the coronal plane of the adductor tendon was 2.2 cm, with a range of 0.6-4.5 cm (in control subjects, 0.9 cm; range, 0.1-2.5 cm; P <.001). At the inferomedial patella, 70% (57 of 82) of LPD examinations showed osteochondral injury and 44% (36 of 82) showed concave impaction deformity (0 of 100 control subjects). Other examination findings in LPDs included contusions of the lateral femoral condyle (66 [80%] of 82 examinations) or medial patella (50 [61%] of 82), intraarticular bodies (12 [15%] of 82), effusion (45 [55%] of 82), medial collateral injury (nine [11%] of 82), and meniscal tear (nine [11%] of 82). CONCLUSION: Injury to the medial retinaculum, MPFL, and VMO may be identified at MR imaging after acute LPD. Concave impaction deformity of the inferomedial patella is a specific sign of prior LPD.

Adult↗
PubMedDate not supplied

Soft-tissue and osseous impingement syndromes of the ankle: role of imaging in diagnosis and management.

Soft-tissue and osseous impingement syndromes of the ankle can be an important cause of chronic pain, particularly in the professional athlete. The main impingement syndromes are anterolateral, anterior, anteromedial, and posterior impingement. These conditions arise from initial ankle injuries, which, in the subacute or chronic situation, lead to development of abnormal osseous and soft-tissue thickening within the ankle joint. The relative contributions of the osseous and soft-tissue abnormalities are variable, but whatever component is dominant there is physical impingement and painful limitation of ankle movement. Conventional radiography is usually the first imaging technique performed and allows assessment of any potential bone abnormality, particularly in anterior and posterior impingement. Computed tomography (CT) and isotope bone scanning have been largely superseded by magnetic resonance (MR) imaging, but the accuracy and role of MR imaging in assessment of possible ankle impingement have not been clearly established. MR imaging can demonstrate osseous and soft-tissue edema in anterior or posterior impingement. Studies of conventional MR imaging have produced conflicting sensitivities and specificities in assessment of anterolateral impingement. CT and MR arthrographic techniques allow the most accurate assessment of the capsular recesses, albeit with important limitations in diagnosis of clinical impingement syndromes.

Ankle Injuries↗
PubMedDate not supplied

Radiographic, CT, and MR imaging features of dedifferentiated chondrosarcomas: a retrospective review of 174 de novo cases.

Up to 11% of chondrosarcomas may undergo regional anaplastic change, resulting in a high-grade noncartilaginous sarcoma arising within a typically low-grade chondrosarcoma. Known as dedifferentiated chondrosarcomas, these tumors are highly malignant with a very poor prognosis. The most important factor affecting survival is an accurate preoperative diagnosis. Therefore, the ability to predict the possibility of dedifferentiation in a malignant cartilage tumor on the basis of imaging findings is critical to ensure adequate tumor sampling at the time of biopsy. Imaging findings at radiography, computed tomography (CT), and magnetic resonance (MR) imaging in 174 patients with dedifferentiated chondrosarcoma were reviewed to determine whether there are radiologic features that can help predict dedifferentiation. On approximately one-third of the radiographs, one-third of the MR images, and one-half of the CT scans, the tumors demonstrated bimorphic features (ie, distinctly different tumor features juxtaposed within the lesion), most frequently a dominant lytic area adjacent to a mineralized tumor at radiography and a large, unmineralized soft-tissue mass associated with an intraosseous chondroid-containing tumor at CT and MR imaging. In the initial evaluation of patients with a primary bone tumor, thorough evaluation of the radiologic features of the entire tumor is critical.

Adolescent↗