Biomedical subjects

Lars Nyberg

Publications and source records attributed to Lars Nyberg.

57 records · Page 4Linked to original sources

PubMed2002

Falls among frail older people in residential care.

AIMS: A prospective study was carried out to investigate the incidence, circumstances, and injuries from falls among frail older people living in three different types of Swedish residential care settings. METHODS: The settings were senior citizens' apartments, an old people's home, and a group dwelling for people with dementia. The falls were registered during the three-year study period on a semi-structured fall report, and injurious falls were categorized according to severity. RESULTS: In total 428 falls occurred among 121 residents. The incidence rate of falls at the group dwelling was twice the rates of the old people's home and senior citizens' apartments (4282 compared with 1709 and 2114 falls per 1000 person-years respectively). Some 27% of the falls occurred during the night (2100h to 0600h) and 28% were related to a visit to the lavatory. The presence of acute disease at the time of a fall was diagnosed in 23% of the falls. Some type of injury occurred in 118 falls (28%) and 36 of these (8%) led to moderate or serious injuries. In total 48 fractures were diagnosed. CONCLUSIONS: In a preventive programme for falls and injuries in residential care settings, areas of particular interest should include falls after mealtimes and falls at night, conditions of acute diseases, rising up from sitting, walking, and activities in progress, especially visits to the lavatory.

Accidental Falls↗

PubMedDate not supplied

High prevalence of white matter hyperintensities in normal aging: relation to blood pressure and cognition.

The occurrence of cerebral white matter hyperintensities (WMHs), and their associations with blood pressure, episodic memory, and other cognitive tasks, were examined in a population-based sample of 123 individuals between 64 and 74 years old. Magnetic Resonance Imaging (MRI) detected subcortical and periventricular hyperintensities in 90% and 67% of the cases, respectively. Subcortical WMHs were related to elevated diastolic blood pressure measured ten years earlier, and periventricular WMHs were related to elevated diastolic blood pressure measured five and ten years earlier. Subcortical hyperintensities were weakly associated with impaired motor speed, but this association was not significant. Periventricular WMHs had a negative effect on episodic memory, although the relation was not linear. Collectively, the notion that white matter hyperintensities impair cognitive function got weak support in this Swedish sample.

Aged↗

PubMedDate not supplied

Levels of processing: a view from functional brain imaging.

This paper briefly reviews two central assumptions of the levels-of-processing framework in the light of findings from recent PET and fMRI studies: First, to address the suggestion that memory traces can be seen as records of analyses carried out for the purposes of perception and comprehension, studies on encoding-retrieval overlap in brain activation patterns are considered. Second, to address the suggestion that deeper, more semantic, processing results in more durable traces, studies of how encoding activity relates to processing depth and subsequent memory performance are examined. The results show that some of the sensory regions that are activated during initial perception are subsequently reactivated during retrieval, and activity in frontal and medial-temporal brain regions is related to depth of processing and level of memory performance. Collectively, these results provide support for central components of the levels framework.

Brain↗