Biomedical subjects
LJ Kricka
Publications and source records attributed to LJ Kricka.
Bioluminescent fusion conjugates and bioluminescent immunoassays: 1988-1998
The first part of this survey focuses on immunoassays and related ligand:binder assays (receptor:ligand, DNA probe) that use either a luciferase or a photoprotein as a label. In addition, references to assays that use a conventional label detected using a bioluminescent assay are included. The second part of the survey collects together references to publications on recombinant fusion proteins in which one of the fused proteins is bioluminescent (e.g., a luciferase or a photoprotein). References are cited by year and then alphabetically by first author. Copyright 1999 John Wiley & Sons, Ltd.
Time-resolved fluorescence: 1996-1998
Luminescence continues to provide comprehensive literature surveys which will be published in most issues. These are a continuation of the literature surveys begun in 1986 in the Journal of Bioluminescence and Chemiluminescence which, up until 1998, encompassed more than 6000 references cited by year or specialized topic. With this newly named journal these searches are expanding to reflect the journal's wider scope. In future we will cover all fundamental and applied aspects of biological and chemical luminescence and include not only bioluminescence and chemiluminescence but also fluorescence, time resolved fluorescence, electrochemiluminescence, phosphorescence, sonoluminescence, lyoluminescence and triboluminescence. The compilers would be pleased to receive any comments from the readership. Copyright 1999 John Wiley & Sons, Ltd.
Luminescence on the internet
This is the first in an occasional survey of Internet sites relating to luminescence. This is just a small selection of available sites and readers are reminded that web pages are sometimes very temporary in nature. The authors welcome details of additional sites of interest to the readers of this journal. Copyright 1999 John Wiley & Sons, Ltd.
Sonoluminescence: 1996-1998
The journal continues to provide comprehensive literature surveys which will be published in most issues. These are a continuation of the literature surveys begun in 1986 in the Journal of Bioluminescence and Chemiluminescence, and which have, up to 1998, encompassed more than 6000 references cited by year or specialized topic. With this newly named Journal these searches are expanded to reflect the Journal's wider scope. In future we will cover all fundamental and applied aspects of biological and chemical luminescence and include not only bioluminescence and chemi--luminescence but also fluorescence, time-resolved fluorescence, electrochemiluminescence, phosphorescence, sonoluminescence, lyoluminescence and triboluminescence, etc. The compilers would be pleased to receive any comments from the readership. Contact by E-mail: L. J. Kricka (larry_kricka@pathla.med. upenn.edu), and P. E. Stanley (stanley@lumiweb.com). Copyright 1999 John Wiley & Sons, Ltd.
Electrochemiluminescence: 1996-1998
The journal continues to provide comprehensive literature surveys which will be published in most issues. These are a continuation of the literature surveys begun in 1986 in the Journal of Bioluminescence and Chemiluminescence, and which have up to 1998, encompassed more than 6000 references cited by year or specialized topic. With this newly named Journal these searches are expanded to reflect the Journal's wider scope. In future we will cover all fundamental and applied aspects of biological and chemical luminescence and include not only bioluminescence and chemi--luminescence but also fluorescence, time-resolved fluorescence, electrochemiluminescence, phosphorescence, sonoluminescence, lyoluminescence and triboluminescence, etc. The compilers would be pleased to receive any comments from the readership. Contact by e-mail: L. J. Kricka (larry_kricka@path1a.med. upenn.edu), and P. E. Stanley (stanley@LUMIWEB.COM). Copyright 1999 John Wiley & Sons, Ltd.
Luminescence news: may-june 1999
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Luminescence News July-August 1999.
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Assays using digital fluorescence: 1985-1998
Luminescence continues to provide comprehensive literature surveys which will be published in most issues. These are a continuation of the literature surveys begun in 1986 in the Journal of Bioluminescence and Chemiluminescence which, up until 1998, encompassed more than 6000 references cited by year or specialized topic. With this newly named journal these searches are expanding to reflect the journal's wider scope. In future we will cover all fundamental and applied aspects of biological and chemical luminescence and include not only bioluminescence and chemiluminescence but also fluorescence, time resolved fluorescence, electrochemiluminescence, phosphorescence, sonoluminescence, lyoluminescence and triboluminescence. The compilers would be pleased to receive any comments from the readership. Contact by e-mail: L.J. Kricka: larry_kricka@path1a.med.upenn.edu or P.E. Stanley: Stanley@LUMIWEB.COM Copyright 1999 John Wiley & Sons, Ltd.
Microchip-based Devices for Molecular Diagnosis of Genetic Diseases.
Microchips, constructed with a variety of microfabrication technologies (photolithography, micropatterning, microjet printing, light-directed chemical synthesis, laser stereochemical etching, and microcontact printing) are being applied to molecular biology. The new microchip-based analytical devices promise to solve the analytical problems faced by many molecular biologists (eg, contamination, low throughput, and high cost). They may revolutionize molecular biology and its application in clinical medicine, forensic science, and environmental monitoring. A typical biochemical analysis involves three main steps: (1) sample preparation, (2) biochemical reaction, and (3) detection (either separation or hybridization may be involved) accompanied by data acquisition and interpretation. The construction of a miniturized analyzer will therefore necessarily entail the miniaturization and integration of all three of these processes. The literature related to the miniaturization of these three processes indicates that the greatest emphasis so far is on the investigation and development of methods for the detection of nucleic acid, followed by the optimization of a biochemical reaction, such as the polymerase chain reaction. The first step involving sample preparation has received little attention. In this review the state of the art of, microchip-based, miniaturized analytical processes (eg, sample preparation, biochemical reaction, and detection of products) are outlined and the applications of microchip-based devices in the molecular diagnosis of genetic diseases are discussed.