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Biomedical subjects

L Zuckerman

Publications and source records attributed to L Zuckerman.

At least 37 records · Page 2Linked to original sources
PubMed1976

Diffusion of oxygen in plasma and blood.

D in fresh human plasma has been found to decrease almost linearly with total protein content over a wide range of concentration and to vary only +/-4% in normals and +/-13% in abnormals. The average values for D in normal human plasma, at 25 and 37 degrees C, are 1.62 and 2.18 X 10(-5) cm2/sec respectively. For normal human blood at 42% hematocrit, the values of D, at 25 and 37 degrees C, are 1.20 and 1.62 X 10(-5) cm2/sec respectively.

Blood Protein Electrophoresis↗
PubMed1976

Thromboelastographic changes in carcinoma: an animal model.

The dynamics of blood clotting using a thrombelastogram (TEG) are depicted after the injection of V2 carcinoma cells or control heterologous peritoneal exudates in New Zealand hares. Changes in the TEG configurations of native blood samples vs. celite activated samples run simultaneously provide a qualitative assessment of the presence of carcinoma.

Animals↗
PubMed1976

In vitro testing of surface thrombogenicity using the thrombelastograph.

Synthetic surfaces can be assessed for their ability to promote or inhibit whole blood coagulation with improved accuracy using a new protocol developed for the Thrombelastograph instrument. Results obtained from the analysis of the hydrodynamic state of blood clotting in Thrombelastograph chambers have enabled a quantitative interpretation of the output of this instrument to be made. The thrombogenic properties of a segmented polyurethane and a polydimethyl siloxane are compared with a preparation of reconstituted elastin. It is seen that a four-fold delay in clotting time is exhibited by reconstituted elastin when it is compared with other biomedical synthetic materials tested.

Adult↗
PubMed1975

Gastric operations and glucose homeostasis. II. glucagon and secretin.

Alimentary hyperglycemia in patients who have undergone gastric operations may be due, in part, to altered intestinal signals for glucose disposition. We measured glucose, immunoreactive insulin (IRI) pancreatic glucagon (IRG), and glucagon-like immunoreactivity (GLI) after oral glucose in patients with prior antrectomy or vagotomy and pyloroplasty and in normal individuals. All subjects had normal assimilation coefficients for intravenous glucose, which suggests that the responsiveness of the pancreatic beta-cells had not been altered by the surgical procedures. The early hyperglycemic response to oral glucose and the associated elevation of plasma GLI were much greater and the IRI levels slightly higher in both experimental groups in comparison to normal subjects. A decrease in the level of IRG, albeit not statistically significant, was noted in all groups after the ingestion of glucose. In gastrectomy patients, secretin infusion during repeated oral glucose tolerance tests partially corrected the hyperglycemia and lowered plasma GLI and IRI levels. The responses of the vagotomy and pyloroplasty patients and of the normal subjects were not altered by secretin infusion. We conclude that the intolerance or oral glucose after gastric surgery may be related to elevated GLI levels, and that the beneficial effect of secretin may be due to its ability to decrease these levels.

Adult↗