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Biomedical subjects

L Zografos

Publications and source records attributed to L Zografos.

At least 109 records · Page 6Linked to original sources
PubMed1980

[Hereditary macular retinoschisis].

The authors examined and studied a family of Italian origin presenting with hereditary macular retinoschisis. Two first cousins of the third generation were affected by this disease. The mode of transmission of the pathologic gene is compatible with a recessive sex-linked heredity. The correlation between the severity of the cystic macular lesions and their functional consequences is not necessarily absolute. The lesions, which appear to be present very soon after birth, increase in severity with the years without any noticeable changes in macular function, which remains weak but stable.

Adult↗
PubMed1979

[Detection of dyschromatopsias and professional orientation].

Certain professions necessitate correct recognition of colour in their practice. Early defection of coloured vision abnormalities and professional orientation are therefore very important, especially as it is known that 8 % of the population presents a congenital dyschromatopsy of which one fourth (about 2 %) are serious dyschromatopsies which will prevent the practice of a certain number of professions.

Color Perception Tests↗
PubMed1979

[The echography of ocular tumours and their microscopic architecture (author's transl)].

The echography of ocular tumours (7 malignant melanomas and 2 metastatic tumours) is presented in correlation with their microscopic architecture. A metastatic tumour presenting echographic characteristics typical of malignant melanoma was considered as such at the ultrasound test. All 7 malignant tumours were diagnosed through the ultrasound test, but it was impossible to foretell a predominant type of cell.

Adenocarcinoma↗
PubMed1979

[Radiotherapy of intraocular tumours (author's transl)].

Ocular radiotherapy has considerably improved during the last 60 years. It allows very often, not only to save an eye, but also to maintain a useful function. But it is only one single element, although important, in our fight against intraocular tumors.

Brachytherapy↗
PubMed1978

Effect of imposed serum deprivation on growth of the mouse 3T3 cell. Dissociation from changes in potassium ion transport as measured from [86Rb)rubidium ion uptake.

Decreased serum concentrations that substantially alter the growth of normal 3T3 cells alter neither the active and non-active components of unidirectional (86)Rb(+) influx nor the intracellular K(+) content when compared with cells in exponential growth. Thus the changes in K(+) transport (measured with (86)Rb(+) as an analogue for K(+) movements) that occur on density-dependent growth inhibition of the mouse 3T3 cell are not mimicked by serum deprivation of the cells before density inhibition.

Animals↗
PubMed1977

[Keractoconjunctivitis caused by type 10 adenovirus].

4 cases in which type 10 adenovirus was isolated are described in connection with a new form of viral keratoconjunctivitis. The predominant symptoms, after disappearance of the benign-type conjunctivitis signs by the 5th day, are those of edema of the lids, chemosis, multiple corneal erosions and folds in Descemet's membrane, reaching their maxima by the 15th day. The course of the disease is of roughly 30 days.

Adenoviridae Infections↗
PubMed1977

[Persistence and hyperplasia of the primary vitreous body].

Persistent hyperplastic primary vitreous is a disease whose spectrum has continued to widen throughout the years; in fact, it probably comprises a number of nosological entities considered as isolated symptoms until today. Our study has shown that the disease can be congenital and affect both eyes in the same individual. The possibility of an etiopathogenic connection with retrolental fibroplasia cannot be excluded.

Adolescent↗
PubMedDate not supplied

Subretinal choroidal neovascularization associated with choroidal nevus.

PURPOSE: Evaluation of a large series of choroidal nevi inducing the formation of a neovascular membrane in order to more clearly define the clinical presentation and to evaluate the efficacy of various treatment options. METHOD: Retrospective study of 22 clinical cases. RESULTS: All nevi were situated in the posterior choroid. They had a mean diameter of 3.8 mm and a mean thickness of 1.4 mm. Neovascular membranes were classic in all cases, extrafoveal in 13 cases (59%), and subfoveal in 9 cases (41%). A serous retinal detachment was present in every case, hemorrhages were present in 13 cases (59%), and lipid deposits were present in 16 cases (73%). All extrafoveal neovascular membranes were successfully treated by thermal laser photocoagulation. Initial visual acuity was 0.1 in three cases, 0.2-0.4 in five cases, 0.5-0.8 in four cases, and 1.0 or more in two cases. Final visual acuity was 0.1 in one case, 0.2-0.4 in one case, 0.5-0.8 in four cases, and 1.0 or more in seven cases. Five subfoveal neovascular membranes were treated either by thermal laser, photodynamic therapy, or irradiation. No treatment was applied in four cases and in one of these cases, spontaneous resolution of the neovascular membrane was observed. No growth of the pigmented tumor was observed with a mean follow-up of 4.8 years. CONCLUSIONS: Proliferation of a neovascular membrane on the surface of a pigmented choroidal tumor is a rare complication and is considered to be a relative indicator of a benign nature of the lesion. In the authors' experience, neovascular membranes are extrafoveal in more than half of cases and are accessible to laser photocoagulation. In contrast, the various modalities used to treat subfoveal neovascular membrane were ineffective and functional prognosis was unfavorable in these cases.

Adult↗
PubMedDate not supplied

Retinal angiomatous proliferation treated with a combination of intravitreal triamcinolone acetonide and photodynamic therapy with verteporfin.

PURPOSE: Retinal angiomatous proliferation (RAP) is a particularly aggressive form of exudative age-related macular degeneration. Response to laser photocoagulation or to photodynamic therapy (PDT) alone is often disappointing. The purpose of this study was to determine whether intravitreal triamcinolone acetate (TA) injections followed by PDT in eyes with early stage RAP may be effective. METHODS: Prospective uncontrolled study, enrolling 11 patients (11 eyes) with stage 2 RAP, treated with intravitreal TA injection followed by PDT. Patients with large pigment epithelium detachment, RAP stage 3, or pre-existing glaucoma and known steroid responders were excluded. All patients underwent a complete ophthalmic examination including fluorescein and indocyanine green (ICG) angiography and optical coherence tomography (OCT-3) at baseline and at 1, 3, 6, and 12 months. Informed consent was obtained from all patients. RESULTS: Mean follow-up was 14.9 months (range 6 C21 months). Mean age was 82 years. In four patients a small pigment epithelium detachment was found on tomography. Initial visual acuity (VA) ranged from 0.1 to 0.6 on the Snellen scale. After calculating the logarithmic values the authors found an initial mean VA of logMAR 0.61, which improved by 1.5, 0.9, and 0.9 log lines after 3, 6, and 12 months, respectively. Although the VA gain from baseline tended to decrease with time, only 2 patients (18%) had an actual loss of acuity>or=3 lines). Retreatment was required in 5 eyes. CONCLUSIONS: In this prospective pilot study examining the use of intravitreal TA followed by PDT with verteporfin in eyes with stage 2 RAP, without a large pigment epithelium detachment, the authors found a potential benefit in terms of stabilization or even improvement of vision.

Aged↗
PubMedDate not supplied

Idiopathic sclerochoroidal calcification: new observations.

Two cases of idiopathic sclerochoroidal calcification are reported with follow-up of two and ten years. In addition we have reviewed 102 cases of choroidal osteoma, including six misleading case reports which actually described idiopathic sclerochoroidal calcification and not choroidal osteoma. Clinical manifestation and the angiographic features of idiopathic sclerochoroidal calcification are outlined. The differential diagnosis of intraocular deposition of calcium salts is discussed in detail.

Aged↗
PubMedDate not supplied

Macular hole in a case of choroidal melanoma.

BACKGROUND: Rhegmatogenous retinal detachment associated with intraocular tumors has been described in a small number of cases. We describe a patient with choroidal melanoma associated with a rhegmatogenous retinal detachment and a macular hole. METHODS: A 71-year-old man underwent enucleation for a bulky pigmented tumor overying the macula. RESULTS: Hystopathological examination revealed moderate cystoid macular edema with a full-thickness macular hole and a mixed-cell type choroidal melanoma. CONCLUSIONS: The relationships between choroidal melanoma, macular hole and rhegmatogenous retinal detachment are discussed.

Aged↗
PubMedDate not supplied

Posterior capsule opacification and wrinkling in a case of capsular bag distension.

We describe a complication following anterior neodymium: YAG laser capsulotomy in a case of capsular bag distension which was diagnosed 21 months after cataract extraction with phacoemulsification and in-the-bag lens implantation. An anterior neodymium: YAG capsulotomy was performed and immediately after this the posterior capsule collapsed and wrinkled, causing a marked decrease in visual acuity that necessitated posterior neodymium: YAG capsulotomy.

Anterior Chamber↗
PubMedDate not supplied

Surface antigenic profile of uveal melanoma lesions analysed with a panel of monoclonal antibodies directed against cutaneous melanoma.

The surface antigenic profile of 10 surgically removed uveal melanoma lesions and 5 conjunctival melanomas was analyzed with a panel of 22 monoclonal antibodies (mAbs) raised against membrane bound cutaneous melanoma-associated antigens (MAA). In addition these lesions were tested for their reactivity with mAbs against MHC class I and II molecules, CD7 (Pan-T) and CD10 (CALLA). The anti-MAA mAbs can be divided into two major groups: first those mAbs detecting markers expressed by the majority of uveal melanomas such as NKI-Beteb, NKI/C3, G7E2, M-2-2-4, Mel-14, G7A5, AMF6, AMF7, Pal M1, Pal M2, Me14/D12. The staining intensity for these mAbs was rather high, ranging in intensity between 70 and 100%. The second group of antibodies includes mAbs detecting markers not or very poorly expressed on ocular melanomas. The anti-ICAM-1 mAb P358 did not react with any of the lesions tested and mAb Muc18 and Muc54 only with one and two out of 15 lesions, respectively. The majority of spindle lesions and mixed type lesions and half of the epitheloid type lesions expressed HLA class I molecules, while HLA class II molecules were found on half of the spindle and epitheloid type lesions and on a small number of mixed cell type lesions. All spindle lesions were found to express the CD10 (CALLA) molecule and less than half of the other type of lesions were stained with an anti CD10 mAb. The melanoma associated ganglioside GD3 was mainly expressed on epitheloid type lesions while GD2 was predominantly expressed on mixed type lesions. In essence, the overall surface phenotype of the uveal melanoma lesions tested, as defined by the panel of mAbs used, differs markedly from the surface phenotype of cutaneous melanoma lesions defined by a very similar antibody panel.

Antibodies, Monoclonal↗
PubMedDate not supplied

[Irradiation of the rabbit ciliary body by an accelerated proton beam].

Rabbit ciliary body has been irradiated by accelerated proton beam. 24 animals have received on 20 and 40% of the total surface of ciliary body 45 and 60 Gy. We could confirm the very good precision of proton beam irradiation. No complication was noticed on slit lamp examination. The light microscope examination revealed haemorrhages, lymphocytes, plasma cells and histiocytes infiltration, late fibrosis and severe capillary alterations. The electron microscope examination showed a frank difference of radiosensitivity of the epithelial layers and a presumed partial rupture of the blood-aqueous barrier.

Animals↗