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Biomedical subjects

L Zala

Publications and source records attributed to L Zala.

36 records · Page 2Linked to original sources
PubMed1983

[Merkel cell carcinoma (trabecular carcinoma) of the skin].

The Merkel cell carcinoma was first designated some years ago by the descriptive term trabecular carcinoma. Both names refer to a skin tumor occurring in elderly patients. This is another example where ultrastructural differentiating criteria are necessary for a definite diagnosis i.e., identification of so-called neurosecretory-like granules by electron microscopy. We report clinical, histological, ultrastructural, and histogenetic aspects of such a disease in a woman suffering from a metastasizing Merkel cell carcinoma.

Adenocarcinoma↗
PubMed1981

[Crosti disease (reticulohistiocytoma type Crosti). Light microscopic, ultrastructural, histochemical and immunohistologic findings].

Four patients with lymphoma-like skin diseases of a protracted course and dubious dignity are reported and reviewed together with similar cases of the literature. These cases correspond largely to the entity termed reticulohistiocytoma which was described by Crosti in 1951. The ultrastructural, histochemical, and immunohistological findings indicate tha the tumoral infiltrate consists of a cell population with close similarities to histiocytes. A possible explanation for the characteristic protracted evolution is an immunologic mechanism is causing an increased cell death rate.

Fibroma↗
PubMed1980

[The Werner syndrome].

Werner's syndrome, also known as "progeria adultorum", manifests itself in young adults. They appear older than their chronological age. Characteristically, there is atrophy in the distal extremities and the face. There is progressive scleropoikiloderma and hyperkeratosis on the foot soles. In the face, there is frequently a "bird-like" expression. Other characteristics are premature graying and early loss of hair, juvenile cataracts, hypogonadism, diabetic symptoms, arteriosclerosis, osteoporosis, small stature with characteristic features, muscle atrophy and cardiac abnormalities. The disease is inherited in an autosomal recessive way. Pathogenesis is unclear. In the following paper, we are reporting the case of a 29 year old saleswoman, who complained of cramps in the calves, and presented the typical symptoms of Werner's syndrome.

Adult↗
PubMed1980

[Eczema of the lower leg--clinical, allergological and differential diagnostic aspects].

More than 50% of patients with dermatitis of the lower legs have a contact allergy. In 60 of our out-patients, the most frequent allergens were found to be balsam of Peru, lanolin and terpentine, followed by benzocaine, p-phenylenediamine, neomycin, oxychinoline, and parabens. Contact sensitization should be chiefly suspected in patients showing resistance to treatment despite apparently adequate therapy, and in those complaining of intolerance to definite topical treatment. Further indices are vesiculation and oozing in the environment of the ulceration, or scattered foci of dermatitis in the face (blepharoedema) or on the hands. The importance of patch testing is emphasized. Suggestions for differential diagnosis and treatment are given.

Allergens↗
PubMed1980

[Carcinoma erysipelatodes (author's transl)].

Carcinoma erysipelatodes (inflammatory metastatic carcinoma) is a rare metastatic carcinoma in the skin. It is usually associated with breast carcinoma, and the prognosis is short-termed. It closely resembles an acute infection, such as erysipelas or cellulitis. 2 patients with this syndrome are presented. One of them had carcinoma of portio uteri. The clinical appearance and the histological pathognomony are described, and a review of the literature is given.

Breast Neoplasms↗
PubMed1977

Photo-onycholysis induced by 8-methoxypsoralen.

Two patients, who we had under surveillance since 1969, were found to develop photo-onycholysis from orally administered 8-methoxypsoralen and sunlight irradiation. Morphological examination of the nail bed revealed characteristics of a microtrauma. The photosensitizing effect of the drug induced the generation numerous binucleate, tetranucleate and multinucleate epithelial cells as well as numerous binucleate and tetranucleate fibroblasts in the dermis.

Administration, Oral↗
PubMed1976

[A follow-up of x-ray-treated tuberous hemangiomas after 15-20 years (author.s transl)].

The treatment of hemangiomas with X-rays has been sharply criticized because of their tendency to involute spontaneously. It has been the aim of this catamnestic study to re-examine for X-ray injury those patients, whose hemangiomas were irradiated 15-20 years ago. The findings indicate that signs of roentgenoderma can appear already with 800 r and increase rapidly over 1,500 r. The observed irreversible damages, however, were mostly not grave, but admonish a certain amount of restraint. An assessment of the effectiveness of low X-ray doses still requires verification considering a faster spontaneous involution.

Dose-Response Relationship, Radiation↗
PubMed1975

[Focal dermal hypoplasia with keratoconus, papillomatosis of esophagus and hidrocystomas (author's transl)].

Focal dermal hypoplasia (Goltz's syndrome, Goltz-Gorlin syndrome), an uncommon malady belonging to the group of congenital poikloderma, is characterized by its broad spectrum of meso-ectodermal defects involving the skin as well as the eyes, skeletal system and teeth. The case represented her is identical with the one published by Naegeli 1926, and contains some additional findings that have not yet been reported, namely: multiple hidrocystomas, bilateral keratoconus, papillomatosis of esophagus, hiatus hernia.

Abnormalities, Multiple↗
PubMed1972

[Case reports].

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Adult↗