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Biomedical subjects

L Z Barkagan

Publications and source records attributed to L Z Barkagan.

At least 19 recordsLinked to original sources
PubMed1991

[Role and physiologic importance of thrombinemia in healthy newborns].

The sensitive orthophenanthroline test was used to reveal paracoagulation in 27 normal newborns, thrombinemia reaching the highest level at the moment of birth and in the period of heavy depression of blood coagulation (on the fifth day of life) was detected. It has been suggested that the physiological role of thrombinemia is in the leveling of hypocoagulation shifts and providing of the local hemostasis. To escape thrombotic complications, drug correction of the hypocoagulation physiological level (activity of prothrombin complex factors is 30-60%) is not recommended.

Humans↗
PubMed1990

[Effect of therapeutic plasmapheresis on the system of hemostasis in patients with chronic glomerulonephritis].

Coagulative and thrombocytic hemostasis as well as the fibrinolytic system were studied in 20 patients with chronic glomerulonephritis on plasmapheresis (PA). It is shown that PA promotes activation of platelet aggregation which can be related to their contact activation. Coagulation enhances, antithrombic potential reduces, fibrinogen is mechanically removed as well as fibrin-monomer soluble complexes, fibrin degradation products. In view of the importance of the fibrinolytic system in chronic glomerulonephritis, measures should be taken to correct the disturbances detected.

Adolescent↗
PubMed1990

[Microtests for evaluating hemostasis and their clinical value].

A system of microtests, adapted for pediatric practice, has been developed, tested, and proposed for practical use. The system includes 13 microtests, 4 of them meet the requirements of a rapid diagnostic test, the others are used as differentiating and specifying. For the first time three levels of the coagulation status have been distinguished in the newborn: physiologic, border and pathologic; this enables orientation in hemorrhagic and thrombohemorrhagic diseases in the newborn. On the basis of the unified microtests the authors have determined the tactics in early diagnosis and follow-up of newborns suffering from hemorrhage treated outpatiently. The diagnosis was verified under dispensary conditions in 158 (66.6%) children with hemorrhagic diathesis. The results of the investigations described are promising for further improvement of the diagnosis and treatment of hemostasis disorders in newborns with the use of the microtests of new generation.

Blood Coagulation↗
PubMed1990

[The mechanisms of intravascular blood coagulation in patients with systemic scleroderma].

Hemostasis was investigated in 2 groups of patients with systemic scleroderma (SSD) with minimal (12 patients) and moderate (9 patients) activity of the process. It has been shown that in SSD, the triggering factor of intravascular blood coagulation is the release of Willebrand's factor, an activator of platelets, from the impaired endothelium. Hyperaggregation and labilization of platelets characterizes the course of SSD irrespective of the disease activity. The main changes in coagulation hemostasis are related to the dramatically accelerated triggered thrombin formation and deficiency of the antithrombin potential. The status of fibrinolysis confirming the thrombogenic situation is marked by a number of features: depression of contact lysis is maximally pronounced in chronic SSD with minimal activity, accumulation of the soluble complexes of fibrin monomer only correlates with the disease activity, and no significant rise of the level of fibrin/fibrinogen degradation products has been discovered.

Adult↗
PubMed1989

[Study of the blood coagulation and fibrinolysis systems in evaluating the activity of glomerulonephritis].

Certain parameters of blood coagulation and fibrinolysis were studied in 84 patients suffering from different variants of chronic glomerulonephritis. The disease is characterized by various conditions of the coagulation system, and acceleration of the initial stages of coagulation; the most typical are disturbances of thrombin inactivation. Simultaneous accumulation in the blood of products of degradation of fibrin and monomeric fibrin complexes is observed. The degree of manifestation of changes in blood coagulation and fibrinolytic systems corresponds to disease activity. The tests used are more sensitive than the traditional clinicolaboratory tests and reveal not only manifested by also latent disease activity.

Adolescent↗
PubMed1989

[Von Willebrand factor in juvenile rheumatoid arthritis].

Forty-three patients with juvenile rheumatoid arthritis were examined. In children with active disease pattern, Willebrand's factor (WF) appeared on the average to be more than twice as increased comparatively to normal. The relationship was established between WF and the characteristics of the inflammatory process activity. The study of the platelet component of hemostasis made it possible to reveal activation of platelet aggregation despite the routine disaggregation and anti-inflammatory therapy, which requires constant laboratory control.

Adolescent↗
PubMed1987

[Participation of leukocytes in primary hemostasis].

Introduction of a hemolysate of erythrocytes and ADP in the plasma containing leucocytes and platelets results in the formation of mixed-cell (leucocytic-thrombocytic) aggregates, aggregation rate depending on the number of leucocytes involved. In healthy donors this process is ensured equally by both cell types. In inflammation and especially in chronic myelocytic leukemia leucocytes play the main role in mixed-cell aggregation. Aggregate formation in such patients is characterized by a high intensity which may be related with an increase in total function of pathological leucocytes.

Adult↗