Studies on the transfer of human delayed-type hypersensitivity. I. Partial purification and characterization of two active components.
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Biomedical subjects
Publications and source records attributed to L Yuan.
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We report a rare case of intractable frontal lobe epilepsy with mental deterioration, in which the measles virus gene was detected from the cerebrospinal fluid (CSF) and peripheral mononuclear cells (PBMC) obtained 9 years after the first epileptic episode using reverse transcriptase-polymerase chain reaction (RT-PCR). The patient had been immunized with an attenuated measles vaccine and had no history of clinically apparent acute measles infection. However the analysis of the sequence of the PCR product from CSF showed the circulating wild strain genotype at the time when the patient complained of his first epileptic episode.
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In Ontario, persons with multiple sexual partners became eligible for free hepatitis B vaccine in late 1991. From January 1992 to January 1993, a sexually transmitted disease (STD) clinic for men in Toronto was one site where the vaccine was delivered. The objectives of the study were to determine the seroprevalence of hepatitis B markers, the series completion rate for hepatitis B vaccine, and the seroprevalence of hepatitis B markers required before screening would be a cost-effective endeavour. The seroprevalence of anti-HBs in gay/bisexual men was 18.1% (95% CI: 15.3%-20.7%) and in heterosexual men was 5.1% (95% CI: 3.0-9.7%). HBsAg was detected in 0.9% (95% CI: 0.04%-1.8%) of gay/bisexual men and was undetected in heterosexual men. Completion of a full vaccine series was 47% for gay/bisexual men and 25% for heterosexual men (p = 0.04). A combined seroprevalence of HBsAg and anti-HBs of at least 30-64%, depending on cost figures used, was required to justify screening prior to completion of a full series.