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Biomedical subjects

L Woods

Publications and source records attributed to L Woods.

52 records · Page 3Linked to original sources

Evaluation of micro serum separator tubes for obtaining serum specimens suitable for serologic testing.

Paired blood samples from Sprague Dawley rats were collected in micro serum separator tubes and in conventional 2 ml volume blood collection tubes. Commercially available ELISA test kits for Mycoplasma pulmonis and Sendai virus were used to compare the two collection systems. No significant differences were found in the optical density values between the two collection systems.

Animals↗

Thromboembolic complications of ventriculoatrial shunts.

Ventriculoatrial shunts were first developed in the 1940s and shortly thereafter became the treatment of choice for noncommunicating hydrocephalus. Although the mortality rate for noncommunicating hydrocephalus has fallen from 80% to 20%, ventriculoatrial shunts continue to have major life-threatening complications such as thromboemboli, infection, and shunt malfunction. This report presents the cases of two adult hydrocephalic patients who developed pulmonary emboli and sepsis after being treated with ventriculoatrial shunts. One patient, whose complications were not recognized until late in the course, died of pulmonary hypertension and right heart failure despite removal of the shunt and aggressive medical therapy. Complications in the second patient were discovered early, the shunt was removed, and intravenous antibiotics were used for weeks to combat sepsis and bacterial endocarditis.

Adult↗

Computer-assisted autoradiographic localization of subtypes of serotonin1 receptors in rat brain.

In vitro light microscopic receptor autoradiography was carried out to localize two subtypes of 5-HT1 receptors in certain regions of the rat central nervous system (CNS). The data were analyzed by computerized digital image processing to reveal subfields of high receptor densities within the septal area, the prefrontal and frontal cortex, and the hippocampus. The septum and hippocampus showed interesting localization of serotonin binding which can be subtyped into 5-HT1-A and 5-HT1-B sites. The differential localization of these sites may be helpful in shedding some light as to the functional significance of multiple serotonin receptors.

Animals↗

Intraocular lens data.

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Catalogs, Commercial as Topic↗

Profound hyperglycemia and metabolic acidosis after verapamil overdose.

Verapamil, a potent calcium antagonist, possesses varied systemic effects, including smooth muscle relaxation leading to both peripheral and coronary artery vasodilation, slowed atrioventricular nodal conduction and decreased insulin release from the pancreatic B cells. Reports concerning the effects of acute intoxication with verapamil are scarce. A case is presented of a 22 year old woman who developed profound hyperglycemia and metabolic acidosis after the inadvertent overdose of thirty 80 mg tablets (2,400 mg) of verapamil. This case illustrates the need for physicians to be aware of verapamil's inhibitory effects on insulin release and to exercise special care when prescribing verapamil in patients with preexisting diabetes mellitus.

Acidosis↗

Pulmonary venous dilatation in pulmonary veno-occlusive disease.

A case of pulmonary veno-occlusive disease in an adult is presented. The diagnosis was suspected clinically and verified at cardiac catheterization. Balloon dilatation of the pulmonary veins was attempted at operation and later again in the catheterization laboratory. The result was a significant reduction in pulmonary venous to left atrial pressure gradient and angiographic evidence of increase in venous diameter. It appears that in the focal form of pulmonary venous occlusion, balloon dilatation may offer a therapeutic approach in an otherwise progressively lethal disease.

Adult↗

Posterior tibial tendon rupture in athletic people.

We present our findings in six athletic patients with a ruptured or partially ruptured posterior tibial tendon. Pain in the midarch region, difficulty pushing off while running, and a pronated flattened longitudinal arch are the usual symptoms and physical findings of this injury. Surgical treatment, including reattachment of the ruptured posterior tibial tendon, is effective in restoring some but not all normal function. Nor will surgery restore the flattened longitudinal arch.

Adult↗

Basal cell carcinoma in a blue-fronted amazon parrot (Amazona aestiva).

Tumors of the integumentary system are relatively common in companion birds. Dermal tumors in pet birds can be epithelial, mesenchymal, or vascular in origin. Basal cell carcinomas appear to be extremely rare in birds. An adult female blue-fronted Amazon parrot was examined because it exhibited bilateral cervical masses that extended from the base of the skull to the ingluvial region. The tumors were removed by surgical excision. Microscopic examination of the masses revealed neoplastic epithelial cells that extended to all borders of the sections; scattered vessels with neoplastic cells within their lumens were also found. The histopathologic diagnosis was basal cell carcinoma. Six weeks postoperatively, the masses recurred and the bird was euthanatized. This report suggests that basal cell carcinomas should be considered as a differential for avian dermal tumors. This neoplastic condition can be aggressive and has the potential to metastasize.

Animals↗