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Biomedical subjects

L Wood

Publications and source records attributed to L Wood.

At least 235 records · Page 13Linked to original sources
PubMed1978

Cardiovascular effects of novel amphetamine analogs in anesthetized rats.

In albino, adult Sprague Dawley rats, anesthetized with urethane intraperitoneally, the effects of the exo- and endo-isomers of 2-amino-5,8-dimethoxybenzonorbornene were studied on arterial blood pressure and heart rate. Both compounds produced an immediate rise in systemic arterial pressure followed by an immediate maximal depressor response. The depressor effect was sustained beyond 30 minute duration, but declined in intensity with time to nearly preinjection levels. Both compounds decreased heart rate in varying degrees. Evidence of marked bradycardia and onset of toxicity was observed at doses of 12.8 mg/kg (exo) and 19.2 mg/kg (endo). The biphasic response seen after intravenous injection of the compounds suggests an initial vasoconstrictory followed by a vasodilatory effect.

Amphetamines↗
PubMed1975

Regional distribution of a 133Xe labelled gas volume inspired at constant flow rates.

We measured the regional distribution of 480 ml of 133Xe labelled gases inspired from FRC at constant inspiratory flow rates ranging from 0.1 to 6 litres/s. The gases used were air and 20% O2 in helium. At low inspiratory flow rates the gas was preferentially delivered to the dependent region of the lung. At maximal inspiratory flows, all regions of the lung were more evenly ventilated. The rate of redistribution was found to be slower and more even than in previous studies using smaller volumes of inspired gas. Assuming equal and synchronous changes of pleural surface pressure, these results can be reasonably predicted by the mechanical time constant theory applied to a simple two-compartment lung model based on equal regional resistances. Breathing the HeO2 mixture did not significantly change ventilation distribution at any flow rate.

Functional Residual Capacity↗