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Biomedical subjects

L Wisniewski

Publications and source records attributed to L Wisniewski.

30 records · Page 2Linked to original sources
PubMed1977

An interstitial deletion of chromosome 9 in a girl with multiple congenital anomalies.

An infant with peculiar facies, coloboma of both eyes, and developmental retardation was found to have d de novo interstitial deletion of the secondary constriction and some adjacent euchromatin on one of her No. 9 chromosomes, del(9)(q11q21). Since studies on duplications, variants, and the molecular composition of the secondary constriction suggest that it contributes little if any information necessary to normal development, deletion of the euchromatin alone is most probably responsible for the clinical findings.

Abnormalities, Multiple↗
PubMedDate not supplied

The effects of calories and taste on habituation of the human salivary response.

The present study examined the effects of calories on salivary habituation. The rate of habituation to lemon taste was studied over 10 trials in 24 normal weight, nondieting, 18-35-year-old females. Between each of the trials, half the subjects ate low calorie, lemon gelatin, total Kcal = 32, and the others ate high calorie, lemon gelatin, total Kcal = 320. A dishabituating, novel chocolate taste was presented on trial 11 and recovery of salivation was assessed by presenting lemon flavor on trial 12. Subjective ratings were taken before and after salivary habituation for hunger levels and hedonics for lemon taste. Results show that high- and low-calorie groups both habituated to the repeated presentation of lemon taste, but with no significant differences as a function of calories in salivation volume, rate of habituation, hunger level decreases, and hedonic decreases. Subjects in both groups perceived equal caloric intake. These results suggest that salivary habituation may be affected more by the sensory characteristics of the food than by differences in caloric intake. The generalization of these data to the development of satiety are discussed.

Adolescent↗
PubMedDate not supplied

Clinical features and computer-aided analysis of chromosome aberration in a case with incontinentia pigmenti.

Incontinentia pigmenti (IP) is an X-linked dominant disease, usually lethal to males. IP belongs to rare diseases involving skin pathological findings, together with neurological and ophthalmological disorders. We here report a two-year old girl with typical symptoms of the IP. A hitherto unreported feature is partial deletion of short arms of one of the chromosomes 15, found in the girl and in her mother. Using an automatic chromosome picture analyzer, a densitometric analysis of the aberration was carried out, in order to determine the break point and to compare the normal and deleted chromosomes.

Chromosome Aberrations↗
PubMedDate not supplied

Differences in salivary habituation to palatable foods in bulimia nervosa patients and controls.

OBJECTIVE: Bulimia nervosa (BN) patients have been shown to experience anomalous responses to food and food cues. We investigated the response to food over time by presenting repeated food cues and measuring changes in physiological (ie, salivation) and subjective responses. METHOD: Subjects were 18 BN women and 18 matched control women. Two palatable food stimuli, regular or frozen yogurt, that varied in macronutrient composition but had similar sensory characteristics, were presented to subjects repeatedly during a laboratory session. After two baseline salivation measures, subjects were presented with eight trials of one of the two yogurts. On Trial 9 a lemon juice dishabituator was presented, with the yogurt stimulus presented again at Trial 10. RESULTS: We found that control subjects had decreased salivation after repeated food presentations. In comparison, BN subjects failed to show a decrease in salivation. The desire to binge increased over trials for the BN subjects, but remained stable for normals. CONCLUSIONS: These data suggest that salivary habituation may be abnormal in BN patients.

Adolescent↗