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Biomedical subjects

L Weissbach

Publications and source records attributed to L Weissbach.

At least 145 records · Page 8Linked to original sources
PubMed1983

[Psychosomatic studies of chronic prostatitis].

The psychosomatic aspects of chronic prostatitis, especially the differentiation of the so-called vegetative urogenital syndrome from chronic state of infection isn't sufficiently clarified. That's why a study of 34 non-selected adult males with symptoms of chronic prostatitis has been undertaken to establish the incidence of infective urological and psychological factors. With urological, bacteriological and radiological examinations we found 44% of the patients with infective-prostatitis, 18% with subvesical disorders and 38% without any pathological findings. Comparing the group of patients with and without pathological urological findings in psychodynamic and testpsychological (Giessen-Test) examinations we couldn't see any significant difference. On the other hand they showed a significant difference compared with a control group of patients suffering from neurotic and/or psychosomatic diseases. Nearly all of our 34 patients showed neurotic disorders irrespective of the urological findings. A special characteristic of their pathogene psychodynamic seems to be the problems in male identity according to internalized disturbed father image. We discussed these results according to psychodynamic and interactional factors of origin and maintenance on chronic prostatitis.

Adult↗
PubMed1983

[Surgical treatment of parenchymal metastases of germinal testicular tumors].

This report concerns 18 patients with germinal testicular tumors in whom the resection of pulmonary metastases was indicated following resection of the primary tumor and combined cytostatic therapy. Nine patients underwent a retroperitoneal lymphadenectomy immediately after semi-castration. Upon follow-up examination, circular pulmonary foci were visualized by conventional films or computerized tomography. These patients developed pulmonary metastases on the average 8 months after the first operation (semi-castration and lymphadenectomy). Since 1978, a combined cytostatic treatment has preceded the lymphadenectomy and resection of parenchymal metastases. No evidence of disease (NED) could be achieved in 9 patients by resection of pulmonary metastases, with an average follow-up period of 30 months. The results in surgery of metastases are judged as the more advantageous, the longer the free interval is between initial disease onset and the occurrence of metastases.

Adolescent↗
PubMed1982

[Mezlocillin versus cefuroxime in urinary tract infections. A multicenter clinical study].

In a multicenter randomised clinical comparative study 96 urological patients with established urinary tract infection were treated in 50% with 2 g mezlocillin three times and in 50% with 1.5 g cefuroxime three times. Both antibiotics were shown to be antibacterially active substances with a high bacterial elimination rate. Three days after cessation of treatment the urine was sterile in 79 cases. Follow-up investigations 1-2 weeks later showed that the number of recurrences and reinfections was higher in the cefuroxime group than in the mezlocillin group. This difference is statistically significant so that mezlocillin can be considered the more effective antibiotic. Clinical and urine cytological results correlated with bacteriological results. Side effects were observed rarely, and toxic effects not at all.

Adult↗
PubMed1982

Evidence for two Na+-independent neutral amino acid transport systems in primary cultures of rat hepatocytes. Time-dependent changes in activity.

Adult rat hepatocytes placed in primary culture contain at least two distinct Na+-independent transport systems for neutral amino acids. The characteristics of the two systems do not allow assignment to previously described Na+ independent agencies, so we have tentatively termed the two processes Systems L1 and L2. Uptake by System L1 is substantially inhibited by cysteine, valine, isoleucine, leucine, methionine, histidine, tryptophan, tyrosine, phenylalanine, and 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid. In contrast, System L2-mediated transport is completely inhibited by isoleucine, leucine, phenylalanine, and 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid. Amino acids transported by both systems show biphasic kinetics yielding Km values for the System L1 component in the micromolar range, whereas the corresponding values for System L2 are an order of magnitude higher. In freshly isolated hepatocytes, the activity of System L2 is relatively high and declines over the initial 24 to 48 h of culture. The Na+-dependent Systems N and ASC also show a significant decay in activity during this time period. In contrast to the decrease in uptake by System L2, transport by System L1 increases during culture following an initial lag period of 12 to 24 h. The increase in System L1 activity can be blocked by the addition of either cycloheximide or actinomycin D. System L1 appears to be present also in fetal hepatocytes, although, in the hepatoma cell line, HTC, the Na+-independent component appears to be homogeneous as though one of the two systems present in the normal adult hepatocyte is not expressed in these transformed cells.

Amino Acids↗
PubMed1982

[Side-effects of polychemotherapy in metastatic testicular neoplasms (author's transl)].

25 Patients with metastatic non-seminomatous testicular neoplasms were treated by surgery and cytostatic therapy using a combination consisting of Velban, Bleomycin, Cis-Platinum and/or Ifosfamid. In 22 patients this procedure induced a persistant complete remission with a mean observation time of 23 months. 2 patients died because of post-surgical complications after a second-look-lymphadenectomy. They suffered from rapidly progressive tumor disease. One patient died in a septicemia during chemotherapy. Our experience is that morbidity of an effective chemotherapy should not be underestimated. Transient bone marrow suppression, anorexia, alopecia and hyperpigmentation are unavoidable. However, severe vomiting, disturbed electrolyte metabolism, hemorrhagic cystitis, anemia and septicemia can well be managed by respective supportive care. Septicemia, for instance, may be treated with appropriate antibiotics without inducing tubular necrosis. Supportive measures also will avoid severe chronic defects of ear and kidney function.

Adult↗
PubMed1982

Clinical, endocrinological, and cytological characterization of two 46, XX males.

In two 46,XX males, 20 and 21 yr of age, gonadotropins, testosterone, and estradiol were measured in serum and compared to those in a control group of four men. In addition, in one subject, androgen metabolism was measured in biopsied skin and cultured skin fibroblasts. In both XX men, a pulsatile pattern of gonadotropin, testosterone, and estradiol release into serum was observed. The levels of the gonadotropins and estradiol were higher and the levels of testosterone were lower in XX men than in normal men. hCG stimulation resulted in a significant increase in testosterone secretion, and LRH administration caused a more prolonged rise in gonadotropin levels in the XX men. The administration of estradiol caused a positive feedback response in the XX men and resulted in a suppression of gonadotropin secretion in the controls. Finally, the formations of C-19 metabolites from testosterone and estrone from androstenedione were found to be in the same range in skin and skin fibroblasts from the XX men as in those from normal men. It can be concluded that 46,XX men have altered hypothalamic-pituitary and gonadal function compared to normal men.

Adult↗
PubMed1982

[Do retroperitoneal vascular abnormalities influence the operability of metastasizing testicular tumors?].

The lymphatic drainage of the testis is closely related topographically to the large retroperitoneal vessels. In retroperitoneal lymphadenectomy (RLA), the surgeon therefore takes the vessel topography as his point of orientation. Typical vascular findings, deviated from the norm, of altogether 285 lymphadenectomies (Jan. 1966-Dec. 1980) are described. The vascular variations do not influence the radicality of the operation. Knowledge of these variations help to prevent vascular lesions. On the other hand, infiltrations of larger vessels entail an extension of the operation. Involvement of the renal vessels (walling in, infiltration) may necessitate nephrectomy. Infiltrations of the wall of the aorta, vena cava or the pelvic vessels are resected and sutured according to the rules of vascular surgery. Involvement of infrarenal and unilateral renal vessels may not be allowed to impede radical extirpation of the tumor.

Adolescent↗
PubMed1981

Treatment of idiopathic varicoceles by transfemoral testicular vein occlusion.

Percutaneous transfemoral occlusion of the testicular vein is a new alternative in the treatment of idiopathic varicocele. Embolization with the Gianturco coil was done on 27 patients. The occlusion was performed immediately after diagnostic phlebography. The results of followup for 1 year are available for 18 patients. In 1 patient the coil had to be removed because of persistent pain, although cause and effect could not be proved. Two patients had a recurrence. The urographic findings were normal 1 year after embolization. No dislocation of the foreign body was observed. Two patients reported that their wives were pregnant.

Adolescent↗
PubMed1981

Enzymatic reduction of oxidized alpha-1-proteinase inhibitor restores biological activity.

The major serum inhibitor of proteolytic activity, alpha-1-proteinase inhibitor (alpha-1-PI), (or alpha-1-antitrypsin) can be readily inactivated by oxidation [Carp, H. & Janoff, A. (1978) Am. Rev. Resp. Dis. 118, 617-621]. This inactivation appears to be due to the oxidation of a critical methionine(s) in alpha-1-PI that is required for the inhibition of elastase activity. An enzyme from Escherichia coli that reduces methionine sulfoxide residues in protein [Brot, N., Weissbach, L., Werth, J. & Weissbach, H. (1981) Proc. Natl. Acad. Sci. USA 78, 2155-2158] can restore the biological inhibitory activity of canine oxidized alpha-1-PI.

Animals↗
PubMed1981

Enzymatic reduction of protein-bound methionine sulfoxide.

An enzyme that catalyzes the reduction of methionine sulfoxide residues in ribosomal protein L12 has been partially purified from Escherichia coli extracts. Methionine sulfoxide present in oxidize [Met]enkephalin is also reduced by the purified enzyme. The enzyme is different from a previously reported E. coli enzyme that catalyzes the reduction of methionine sulfoxide to methionine [Ejiri, S. I., Weissbach, H. & Brot, N. (1980) Anal. Biochem. 102, 393--398]. Extracts of rat tissues, Euglena gracilis, Tetrahymena pyriformis, HeLa cells, and spinach also can catalyze the reduction of methionine sulfoxide residues in protein.

Animals↗
PubMed1981

Immunohistochemical localisation of alpha-fetoprotein (AFP) in germ cell tumours: evidence for AFP production by tissues different from endodermal sinus tumour.

20 germ cell tumours have been studied with respect to the presence of alpha-fetoprotein (AFP), using the peroxidase-antiperoxidase (PAP) technique. 6 out of 20 tumours contained elements of endodermal sinus tumour (EST) and were AFP positive. 16 tumours were diagnosed either as pure embryonal carcinomas (6) or as mixed germ cell tumours, containing elements of embryonal carcinoma (10). In 3 of these 16 tumours AFP was localised definitely in the embryonal carcinoma cells; in an additional 6, AFP was also detected but it could not be decided whether AFP was present in embryonal carcinoma cells or in EST cells during early differentiation. In 2 of 7 immature teratomas, AFP was shown to be present in cylindric epithelia. All seminomas (4) studied were AFP-negative. These results show that AFP, which occurs regularly in EST, may also be present in embryonal carcinomas as well as in immature teratomas. Thus, it seems that the immunohistochemical demonstration of AFP by the PAP technique is a suitable method of identifying late stages of embryonal carcinoma or early stages of endodermal sinus tumour during the process of differentiation.

Dysgerminoma↗
PubMed1981

[Operative removal of tumor thrombus from vena cava in hypernephroid carcinoma (author's transl)].

The prognosis of renal cell carcinoma correlates with the aggressiveness of surgery, especially in patients with involvement of the vena cava. Without significant bleeding the operative management and the successful removal of a free floating tumor thrombus from the vena cava has been described. In a 69-years old female patient the vascular surgery consists of cross clamping of the vena cava with free back-flow of the contralateral renal vein, cavotomy, insertion of a Fogarty catheter for occlusion of the suprarenal vena cava without blocking the liver veins, and extraction of the thrombus.

Adenocarcinoma↗
PubMed1981

[Multicystic renal dysplasia in the adult (author's transl)].

In the literature 59 cases of multicystic dysplasia of the kidney in adults have been reported. Many authors use different descriptions to characterize the same aspect of identical disease causing a confusing nomenclature. The disease is caused by a malformation in development. On the basis of three clinical case reports diagnosis, differential diagnosis and prognosis is discussed. One patient had an additional malformation (M. Klippel-Feil).

Adult↗
PubMed1981

[Surgical therapy of germinal testicle tumors (author's transl)].

Surgical intervention in patients with germinal testicular tumors is performed to obtain the exact tumor histology and to define the stage of disease. This can be achieved by inguinal orchiectomy and retroperitoneal exploration. In cases without metastases, a modified retroperitoneal lymphadenectomy (LA) can reduce operative morbidity. With regard to the juvenile age of the patients, protection of ejaculation is of particular importance. If retroperitoneal lymph node metastases are present radical LA should be performed. In case of infiltration of ureters or kidney pedicles a coincident of nephrectomy becomes necessary. Palliative primary surgery should be avoided by exact preoperative diagnosis. In patients presenting with primary inoperable tumors chemotherapy should be instituted prior to surgery. A more radical treatment is necessary if residual tumor has to be removed in a second look operation or after chemotherapy, respectively. Resection of metastases is particularly indicated in cases with mediastinal or pulmonary spread.

Antineoplastic Agents↗