Search PubMed⌕ Search

Biomedical subjects

L Weinstein

Publications and source records attributed to L Weinstein.

At least 163 records · Page 9Linked to original sources
PubMed1975

Inactivation of Treponema pallidum by silver sulfadiazine.

Silver sulfadiazine, an anti-infectious agent for the prevention and treatment of burn sepsis, has been found to possess antitreponemal activity against Treponema pallidum. At 28 C, complete inactivation of the organism was produced by exposure of the organism to a concentration of 50 mug of the drug per ml for 1 to 5 min, 12 to 25 mug/ml for 10 to 15 min, and 6.2 mug/ml for 30 min. At 37 C, the amounts of silver sulfadiazine required for inactivation were two- to fourfold less.

Animals↗
PubMed1975

Prevention of herpes keratoconjunctivitis in rabbits by silver sulfadiazine.

Silver sulfadiazine, at a concentration of 10 mug/ml when applied immediately after infection by Herpesvirus hominis, prevented the development of acute herpetic keratoconjunctivitis in rabbits. The efficacy was inversely related to the size of inoculum. Subclinical infections were observed in the drug-treated eyes.

Animals↗
PubMed1975

Relation between lipophilicity and pharmacological behavior of minocycline, doxycycline, tetracycline, and oxytetracycline in dogs.

Four tetracyclines were studied in dogs to determine the relation between their lipophilicity and various other pharmacological characteristics. Lipid solubility correlated inversely with the mean concentration of drug in arterial plasma and renal uptake and excretion, and directly with the biliary concentration gradient (level in bile/level of free drug in serum). Only the more lipophilic congeners minocycline and doxycycline passed the blood-brain and blood-ocular barriers in detectable concentrations. Mean levels of minocycline in the brain exceeded those of doxycycline by almost threefold; the difference was of borderline statistical significance (P = 0.05 to 0.1). Lipophilicity correlated inversely with the concentration of antibiotic in renal medulla but not in renal cortex or in the liver. When intestinal loops containing saline, milk, or 10% Gelusil were studied, the only combination exhibiting striking intraluminal accumulation was doxycycline in milk. These results indicate that lipophilicity correlates with many, but not all, of the transport characteristics of tetracycline antibiotics.

Animals↗
PubMed1975

[Communication and teamwork in a modern hospital].

The problems facing a modern hospital, which mirror the crisis confronting medicine as a whole, are reviewed. In the search for solutions to these difficulties it is necessary to envisage the hospital in a larger context and examine the role it should play in society. And a comprehensive approach that takes into account all the different elements involved in the work of a hospital-administration, medical care, teaching, research-is fundamental. All teamwork presupposes certain dimensional factors such as organization, dynamics, and productivity. And each member of the health team must identify with the work of the group as a whole, providing for a degree of "realization of individual potential" which ultimately comes together with the primary goal-namely to work toward the health of the patient. The various forms of communication in the hospital, both between individual departments and between the members of each team that has a part to play, are also reviewed.

Hospital Administration↗
PubMed1975

Photodynamic inactivation of herpesvirus hominins by methylene blue (38524).

Methylene blue, in a concentraion of 10-5M was virostatic in the presence of light but not in the dark for 31 of 37 strains of fresh isolates of herpesvirus hominis. Resistance to the dye developed during treatment. This photodynamic pattern was almost identical to that of neutral red which produced an identical effect. This was not ture for proflavine which was active in the dark in many instances. Cross insensitivity between proflavine and methylene blue was not observed.

Coloring Agents↗