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Biomedical subjects

L Weinstein

Publications and source records attributed to L Weinstein.

310 records · Page 18Linked to original sources
PubMedDate not supplied

Vaginal retention of 2% butoconazole nitrate cream: comparison of a standard and a sustained-release preparation.

The purpose of this study was to establish the length of time that butoconazole nitrate 2% standard cream and sustained-release cream could be detected in the vagina after a single administration of 5 g of cream that contained 100 mg of butoconazole. Sixteen healthy subjects received a single vaginal dose of either the standard (8 patients) or the sustained-release preparation (8 patients). Participants returned daily for vaginal examination and collection of specimens to determine the presence of the drug. The specimens were analyzed for butoconazole content using high-performance liquid chromatography. All subjects in both groups had detectable levels of butoconazole present in the vagina for the first 2 days of the study. The sustained-release cream was demonstrated to be present in the vagina in 7 subjects on the third day, 5 on the fourth day, and 1 on the seventh day, while only 1 subject who received standard cream retained it on the third day and none did so thereafter. Analysis of these data demonstrated a median vaginal retention time of 2.57 days with the standard cream and 4.20 days for the sustained-release preparation (P = 0.0024).

Administration, Intravaginal↗
PubMedDate not supplied

The CLIPED procedure: an attempt to improve perinatal outcome in hopeless situations.

The purpose of this study was to prevent delivery in women who at < 23 weeks' gestation were in premature labor with excessive cervical dilation and membranes prolapsed into the vagina. Six patients were seen at gestational ages of 17 to 22.5 weeks in premature labor with cervical dilatation of 2 to 8 cm and membranes prolapsed into the vagina. There were three singleton pregnancies, two sets of twins, and one set of triplets. Cerclage placement was successful in five of six patients and one patient had ruptured membranes at operation. One fetus died the day after successful cerclage. The average prolongation of gestation was 33 days in the remaining four patients. It is our opinion that the poor prognosis of a patient at < 23 weeks' gestation in premature labor with excessive cervical dilatation and membranes prolapsed into the vagina may be altered with cerclage placement. We suggest that patients at > or = 21 weeks' gestation with prolapsed membranes whose contractions have been stopped be considered for cerclage late in pregnancy with excessive dilation (CLIPED procedure). The average amount of time a gestation is prolonged may preclude the procedure before 21 weeks.

Adolescent↗
PubMedDate not supplied

The substance abuse subtle screening inventory is more cost effective and has better selectivity than urine toxicology for the detection of substance abuse in pregnancy.

OBJECTIVE: To compare the SASSI as a screen for substance abuse in pregnancy with the patient history and toxicology screening. STUDY DESIGN: On 560 patients the substance abuse history and urine toxicology was obtained at registration in the prenatal clinic. Each patient also completed the SASSI questionnaire. The SASSI was compared with each screen individually and the result of the SASSI and the patient's history were combined for comparison with the toxicology results. RESULTS: SASSI was found to be more selective as a screen for substance abuse than urine toxicology and it gave a profile of alcohol use which was absent on the toxicology screen. CONCLUSIONS: The SASSI is a more effective clinical tool for identifying substance abuse and more cost effective than toxicology screening.

Adolescent↗