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Biomedical subjects

L Weed

Publications and source records attributed to L Weed.

6 recordsLinked to original sources
PubMed1983

Primary harderian gland neoplasms in mice.

Five hundred and seventy-four spontaneous harderian gland neoplasms were observed in 3,123 male and 9,024 female untreated experimental mice of various ages and of 6 inbred strains and substrains and 3 hybrid stocks. Adenomas occurred in 86 males and 458 females, and adenocarcinomas were present in 3 males and 27 females. The highest tumor incidence occurred in mice after 24 months of age; no tumors were observed in any mice prior to 6 months of age. With the exception of 1 age group, both sexes of the BALB/c mice had the highest incidence, and also this strain accounted for 463 of the neoplasms. The adenomas were classified into one of four different histologic types: papillary, cystic papillary, acinar, and cystic. The papillary type was the most frequently observed in both sexes. The cystic papillary type was the second most frequently observed and was the type most frequently associated with gross lesions. This type may represent a developmental variant of the papillary type. The incidence of the acinar type was similar in both sexes. The cystic type had the lowest incidence. All except 3 adenocarcinomas appeared to evolve from adenomas, with evolvement occurring primarily in the acinar type. Five of the adenocarcinomas either metastasized to the lung or invaded periorbital tissues. The remaining 25 were confined to the harderian gland.

Adenocarcinoma↗
PubMed1982

Distribution of mammary gland neoplasms and factors influencing metastases in hybrid mice.

Mammary neoplasms in yellow (C3H x VY-A vy) F-1 virgin female mice with the murine mammary tumor virus were distributed equally between the left and right sides. The ratio of thoracic to inguinal gland involvement was 6.4 to 3.6 indicating that the A vy mutation, which enhances age-specific mammary tumor incidence, apparently does not affect the distribution of mammary tumors. The average tumor size was similar in all mammary glands. Multiple tumors occurred seven times more frequently in the thoracic than in the inguinal glands. Metastases occurred more frequently in moribund mice than in those killed at a scheduled time, and the incidence of pulmonary metastases in both groups was associated with the duration of the mammary tumors, their size, their location, and the number of neoplasms. Adenocarcinomas in the thoracic glands metastasized to the lungs more frequently than those in the inguinal glands.

Animals↗