Dichlorvos-containing dog collars and thiamylal anesthesia.
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Anesthesia, Intravenous↗
Biomedical subjects
L Weaver
Publications and source records attributed to L Weaver.
Stream surveillance programs.
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Health Surveys↗
Beta-sheet models for the ordered filamentous structure formed by a peptide that enhances the action of insulin.
Certain peptides with sequences related to part of the major histocompatibility complex class I antigen enhance the action of insulin. These peptides also aggregate into fibrous structures that seem to be related to their biological activity. In the current study, the 17-residue peptide with amino acid sequence Gly-Asn-Glu-Gln-Ser-Phe-Arg-Val-Asp-Leu-Arg-Thr-Leu-Leu-Arg-Tyr-Ala is used as a representative example of these bioactive molecules. As seen by electron microscopy, the peptide associates into gently twisted ribbons, 50 A thick, in which the amount of twist decreases as the ribbons become wider. X-ray diffraction analysis suggests that the peptides are arranged as in an antiparallel beta-sheet extending essentially endlessly along the fiber axis. The amino acid sequence of the peptide is such that one side of the beta-sheet is predominantly polar while the opposite side is nonpolar. This allows the beta-sheets to form multilayers with alternating hydrophobic and hydrophilic interfaces. The length of the extended peptide (approximately 54 A) determines the thickness of the ribbon and the tendency of individual beta-sheets to twist accounts for the twisting of the ribbons. An alternative model is also discussed, again based on antiparallel beta-sheets, but with adjacent sheets interdigitated in a "side-by-side" fashion rather than forming stacked layers. Comparable inactive peptides such as Gly-Asn-Glu-Gln-Ser-Ala-Arg-Val-Asp-Leu-Arg-Thr-Leu-Leu-Arg-Tyr-Tyr (changed amino acids underlined) do not form ordered filamentous structures.
Amino Acid Sequence↗
Satisfaction with prepared childbirth and locus of control.
The study tests the hypothesis that there is a positive association between a sense of personal control (internal locus of control) and satisfaction with the experience of prepared childbirth. Women delivering at a university hospital were studied by the administration of the Rotter I-E Scale and a postpartum questionnaire. The results demonstrated that internal locus of control was related to satisfaction in the prepared group of women. Class attendance alone did not distinguish the subjects with respect to satisfaction.
Attitude to Health↗
The effect of enteral glutamine deprivation and supplementation on the structure of rat small-intestine mucosa during a systemic injury response.
BACKGROUND: An aseptic model of tissue injury (the induction of abscesses by subcutaneous injections of turpentine) was used to examine the proposal that changes in glutamine metabolism lead to structural damage in the epithelium of the small intestine during the systemic response to injury and to investigate the role of dietary glutamine in the maintenance of mucosal structure in the small intestine of control and injured rats. METHODS: Glutamine-free and glutamine-rich (3.6% glutamine by weight) diets were fed to rats before and during an acute-phase response to injury. Pair-fed groups of animals enabled an independent assessment to be made of the effects of the associated dietary restriction on the mucosal epithelium. RESULTS: Adaptive increases in villus height and crypt depth were seen in response to 4 days of feeding of the glutamine diet. Pair-feeding (30% dietary restriction) of either diet induced mucosal atrophy (loss of wet weight and nitrogen) without changes in villus height or crypt depth in the proximal tercile of the small intestine. Systemic injury, however, had no effect on the weight or nitrogen content of the mucosa (relative to pair-feeding). Gross histologic appearance, villus height, and crypt depth were also unchanged by the response to injury. CONCLUSIONS: The study provided no evidence to support the proposal that alterations in the availability of dietary glutamine during systemic injury (induced by turpentine injections) lead to structural damage to the epithelium.
Animals↗
Uniforms: a strange custom?
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Attitude of Health Personnel↗