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Biomedical subjects

L Wagner

Publications and source records attributed to L Wagner.

At least 343 records · Page 19Linked to original sources
PubMed1993

MHC-independent presentation of mycobacteria to human gamma delta T cells.

The majority of human peripheral gamma delta T cells express antigen receptors using the V gamma 9 and V delta 2 gene products. Cells of this subset have been previously shown to uniformly recognize mycobacteria regardless of their V-(D)-J junctional sequences in an MHC-unrestricted manner. This reactivity superficially resembles activation of alpha beta cells by bacterial superantigens, which are thought to be presented by monomorphic regions of MHC class II molecules. It is not known whether presentation of the mycobacterial antigen to V gamma 9/V delta 2 T cells is also mediated by class II MHC molecules. In order to examine the similarity between presentation of bacterial superantigens to alpha beta T cells and the presentation of mycobacteria to gamma delta T cells we have studied the role of class II MHC molecules in presentation of the mycobacterial antigen AP-MT to V gamma 9/V delta 2 clones. Activation of gamma delta T cells by AP-MT required direct contact with antigen presenting cells, indicating that an interaction with cell surface molecules on antigen presenting cells is required. Class II MHC molecules were neither sufficient nor necessary for effective presentation of AP-MT to the gamma delta T cells, as transfectants expressing class II MHC molecules were unable to present, whereas cell lines lacking expression of MHC class II molecules could present this mycobacterial antigen.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1993

Prevalence of chronic fatigue syndrome-related symptoms among nurses.

Chronic Fatigue Syndrome is an illness that is characterized by debilitating fatigue and a group of other related symptoms. Few epidemiological studies have been conducted, and none have focused on a nursing population. The present study is the first to assess the prevalence of Chronic Fatigue Syndrome-related symptoms in a sample of nurses. Demographic characteristics, symptoms, and possible prevalence rates are presented and discussed. When using both narrow and more inclusive criteria to define this symptom complex, higher rates of this disorder were found than in previous epidemiological studies. The implications of these findings are discussed.

Adult↗
PubMed1992

'Trim-the-deficit push would aid reform.'.

A deficit-reduction bill will offer the most likely legislative vehicle for a healthcare reform proposal next year, one member of the House Ways and Means health subcommittee said. Rep. Benjamin Cardin (D-Md.), speaking to the National Association of Public Hospitals earlier this month, also said, "There is no perfect healthcare reform proposal. We need to take risks and move forward."

Budgets↗
PubMed1992

Ambitious goals, political shoals.

President-elect Bill Clinton's vaunted skills as a consensus-builder will be put to the test next year as he advances a healthcare reform agenda. His ambitious proposals, which could produce the most sweeping changes in delivery and financing since the 1965 enactment of Medicare and Medicaid, must be steered through a sea of special interests and diverse congressional reform plans.

Cost Control↗