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Biomedical subjects

L W Powell

Publications and source records attributed to L W Powell.

At least 271 records · Page 15Linked to original sources
PubMed1969

Primary intrahepatic obliterating cholangitis: a possible variant of 'sclerosing cholangitis'.

A sclerosing cholangitis confined to the intrahepatic ducts occurred in a 64-year-old man with a clinical picture of prolonged cholestatic jaundice. Two laparotomies and an operative cholangiogram demonstrated a normal extrahepatic biliary tree. The most prominent histological feature in the liver biopsy was the replacement of medium-sized bile ducts by fibrous cords. Electron microscopic examination of the liver showed changes attributable to cholestasis and cholesterol clefts in dense bodies. Needle-like and curved membrane-bounded inclusions of an obscure nature were also observed in some of the dense bodies. It is suggested that this case, together with nine histologically similar cases which have been labelled in the literature as ;primary biliary cirrhosis', represents a subgroup of sclerosing cholangitis in which only the intrahepatic ducts are affected.

Bile Ducts, Intrahepatic↗
PubMed1968

Red cell survival after Heterograft valve surgery.

Intravascular haemolysis was studied in 24 patients three to nine months after calf or pig valve heterografts had been inserted for severe valvular heart disease. No patient had haemolytic anaemia. In five of the 24 patients there was subclinical haemolysis, and in these five the haemolysis appeared to be related to residual aortic regurgitation or to the presence of other foreign material such as a Dacron aortic graft. The extent of postoperative haemolysis in these five patients was comparable to that observed preoperatively in patients with valvular heart disease.The results support the belief that, in contrast to artificial valve prostheses, heterograft valves behave similarly to human valves as regards haemolysis.

Adult↗