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Biomedical subjects

L W Henderson

Publications and source records attributed to L W Henderson.

At least 19 recordsLinked to original sources
PubMed1978

Current status of hemofiltration.

Hemofiltration is reviewed from the standpoint of the technical and clinical state of the art. It is a new technique and, at present, commercially available equipment is limited. Clinical experience suggests that hemofiltration results in easier attainment of salt and water balance and that control of hypertension is improved. The nomenclature used to describe convective solute and water removal alone and in conjunction with dialysis is outlined.

Extracorporeal Circulation↗
PubMed1978

Middle molecules re-examined.

Evidence for and against the presence and pathophysiologic importance of middle molecules in uremia is reviewed. The evidence favors both their presence and importance.

Filtration↗
PubMed1978

Hemofiltration.

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Costs and Cost Analysis↗
PubMed1978

Hemofiltration.

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Filtration↗
PubMed1978

Continuous low flow hemofiltration with sorbent regeneration of ultrafiltrate.

In summary, a series of experiments have culminated in the maintenance of 2 anephric sheep for 48 and 72 hrs with CLF-HF treatment. Ewe A died of hemorrhage secondary to systemic heparinization and recent surgery. Ewe B was terminated electively. The technique of CLF-HF proved satisfactory in the control of urea, creatinine and water. Sodium and hydrogen ion balance required substantial therapeutic manipulations in addition to CLF-HF to maintain satisfactory balance with the present system. Technical and functional performance of the ultrafilter was better than anticipated. Cartridge performance was sufficiently satisfactory to demonstrate that the procedure will work. The unphysiologic linking of urea, hydrogen and sodium sorption resulted in difficulty in maintaining satisfactory sodium and hydrogen balance. Coupling a disposable reprocessing system, which lacks the deficiencies mentioned above, with continuous hemofiltration can provide a truly wearable artificial kidney.

Animals↗
PubMed1978

Hemofiltration.

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Humans↗
PubMed1977

Hemodiafiltration.

Four patients have been studied with maintenance hemodiafiltration. The predominant finding to date has been better control of blood pressure. The mechanism(s) for this improved blood pressure control are under study.

Humans↗
PubMed1976

Glomerulonephritis.

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Adrenal Cortex Hormones↗
PubMed1976

Control of breathing in uremia: ventilatory response to CO2 after hemodialysis.

The mechanisms responsible for the transient respiratory alkalosis which follows clinical hemodialysis were evaluated by studying the ventilatory response to carbon dioxide in chronic uremic patients, and in unanesthetized normal and chronic uremic goats. A significant increase in sensitivity to CO2 was found in acidotic uremic patients immediately (within 30 min) following hemodialysis (P less than 0.01). Sensitivity to CO2 returned to the predialysis value within 24 h. Lung volume and maximal breathing capacity were unchanged. A similar increase in sensitivity to CO2 was seen in nonacidotic uremic goats following hemodialysis. In the goats, these changes in sensitivity could not be explained by changes in cerebrospinal fluid acid-base status. Adding sufficient urea to the dialysate to prevent a fall in plasma urea concentration, eliminated this increase in sensitivity to CO2 in both uremic patients and goats. These results suggests that the transient respiratory alkalosis following hemodialysis is due to an increase in the sensitivity of the ventilatory response to carbon dioxide and is a consequence of dialysis-induced osmotic disequilibrium.

Adolescent↗