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Biomedical subjects

L W Burgher

Publications and source records attributed to L W Burgher.

At least 19 recordsLinked to original sources

Laser endoscopy.

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Endoscopy

Lung recoil and gas trapping during oxygen breathing at low lung volumes.

If airways are closed at lung volumes less than the closing volume (CV), there should be correlations among 1) the volume of trapped N2 (VTN) during N2-washout performed below CV, 2) the increase in static lung recoil pressure (delta P) while breathing below CV after denitrogenation compared with breathing air (due to absorption atelectasis distal to closed airways), and 3) the CV. Static inspiratory pressure-volume (PV) curves and CV were measured in 18 seated normal volunteers (ages 24-48 yr). Subjects then breathed air for 30 s and O2 for 2.5 min at RV + 0.6 liter (LVB-air), and an inspiratory PV curve and VTN were determined. While still breathing O2, the subjects repeated the 3 min of low-volume breathing (LVB-O2). There was a significant (P less than 0.001) delta P with LVB but no difference between delta P (LVB-air) and delta P (LVB-O2). CV was not related to VTN or to either delta P. VTN was not related to delta P (LVB-O2)--delta P (LVB-air) nor to delta P (LVB-air), but was related to delta P (LVB-O2). Evidence of airway closure could not be demonstrated in all subjects by LVB and when present showed no correlation with CV.

Adult

The clinical and pathologic correlation of fat embolism syndrome.

The fat embolism syndrome is a well-defined clinical entity that can usually be recognized in patients who have long-bone fractures. Cerebral symptoms of restlessness, confusion, stupor, and coma correlate with the autopsy findings of fat in the brain, but the amount of fat or amount of petechial hemorrhage cannot be quantitated with the severity of the cerebral symptoms. There is a correlation between the clinical manifestations of dyspnea and tachypnea and the autopsy findings in the lungs, which are heavy from edema and alveolar hemorrhage; however, we cannot correlate the degree of pathologic change in the lung, including lung weights, with the severity of findings clinically.

Accidents