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L Voigtmann

Publications and source records attributed to L Voigtmann.

At least 37 records · Page 2Linked to original sources
PubMed1986

[Computerized tomography studies in the assessment of radiogenic pneumopathy in an animal experiment].

An animal experimental study was conducted in 56 piglets exposed to radiation to establish new assessment criteria on radiogenic pneumopathy by employing computed tomography for diagnosis. The accurately measurable density changes in the lung parenchyma exposed to radiation appear invariably as soon as a dose-dependent threshold value is exceeded. Tolerance limits can be determined for 60Co and neutron irradiation in different fractions and single doses, the enhancement of lung density being correlated with the irradiation dose. It is not possible to establish a volume-dependent decrease in the tolerance dose. Likewise, there is no radiation-promoted co-reaction of adjacent pulmonary tissue not subjected to irradiation exposure. These results apply to the experimental animals used in the study.

Animals↗
PubMed1986

[Dose-time correlation in the irradiation of the lung of piglets for evaluating a model of human radiogenic pneumopathy].

Dose-time relationships with respect to a pulmonary radiogenic reaction were studied in 62 improved-breed pigs aged 3 mos. with the mass of 20-30 kg. The animals received fractionated irradiation with 60Co. Irradiation and its doses were computed in a way similar to that used in clinical practice. Clinical evidence, respiration rate, chest x-ray, histological and biochemical investigations of pulmonary tissue served as quantitative criteria of pulmonary lesion. ED50 was determined, i.e. a dose at which 50% of the experimental animals fell ill. The number of fractions produced a greater effect on an isoeffect curve than the entire period of irradiation. The pulmonary radiogenic reaction in pigs could be expressed by the calculation D approximately N0,32 T0,05. A possibility to introduce the results of the experiments on pigs into clinical practice allows practical use of the dose-time relationships obtained in the experimental studies.

Animals↗