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L Vogt

Publications and source records attributed to L Vogt.

At least 19 recordsLinked to original sources
PubMed2006

[Sports medical aspects in cardiac risk stratification--heart rate variability and exercise capacity].

The present study investigates the association of the predicted CHD-risk (PROCAM) with the individual endurance capacity and heart rate variability (HRV) in a population-based sample of sedentary elderly. After stratification, in 57 men (48.1+/-9.5 yrs.) with an overall PROCAM-risk <10% (28.7+/-10.9 points) and 22 men (54.5+/-7.7 yrs.) with a coronary 10-year risk > or =10% (50.8+/-5.6 points) cycle ergometries and short-term HRV analysis of time (RRMEAN, SDNN, RMSSD) and frequency domain parameters (LF, HF, TP, LF/HF) were conducted. Additionally the autonomic stress index (SI) was calculated. Nonparametric tests were used for statistical correlation analysis (Spearman rho) and group comparisons (Mann-Whitney). For endurance capacity [W/kg] (r=-0.469, p<0.001), SDNN (r=-0.302, p<0.05), RMSSD (r= -0.311, p<0.05), LF (r=-0.325, p<0.05), HF (r= -0.311, p<0.05) and TP (r= -0.307, p<0.05) negative monotone correlations with the coronary score-risk were determined. Significant positive correlations were calculated for SI (r=0.476, p<0.001). Except for RRMEAN and LF/HF significant group differences (p<0.05) were computed for SDNN (30.0+/-20.0 vs 20.0+/-10.0 ms), RMSSD (22.2+/-18.3 vs 18.0+/-8.7 ms), LF (90.9+/-241.5 vs 41.35+/-81.1 ms(2)), HF (43.0+/-105.1 vs 18.0+/-27.0 ms(2)) and TP (189.0+/-457.1 vs 100.0+/-157.6 ms(2)). Significant differences (p<0.01) were evaluated for exercise capacity (2.4+/-0.5 vs 1.8+/-0.3 W/kg) and SI (90+/-183 vs 322+/-291). The results underline the predictive value of HRV analysis in risk stratification and outline the interrelation of a decreased exercise capacity and autonomic function with a raised individual 10-year cardiac risk. As an independent parameter of the vegetative regulatory state the stress index may contribute to an increased practical relevance of short-time HRV analysis.

Adult↗
PubMed2004

Occult, life-threatening, cardial tumor in syndactylism in Gorlin Goltz syndrome.

Pediatric, orthopedic, plastic, and hand surgeons perform the surgical correction of syndactylism. It is sometimes forgotten, however, that syndactylism can be part of a syndrome. The components of such a syndrome can each be life threatening. A 7-month-old boy was hospitalized for correction of cutaneous syndactylism. The mother claimed that, with the exception of the syndactylism, her son was healthy. However, review of the admission documents found that the family physician suspected Gorlin Goltz syndrome. A preoperative echocardiography showed 3.9-cm intramural tumor in the wall of the left ventricle. Electrocardiography documented ventricular tachycardia. Because of the danger of life-threatening malignant ventricular tachycardia, the tumor was resected. Before the resection, cardiac transplantation was considered because of the size of the tumor. Histologic examination found a fibroma. When observing syndactylism, one must always be aware of the possibility of a syndromic disease. It is particularly important that screening investigations, including electrocardiography and echocardiography, are performed before surgical treatment.

Basal Cell Nevus Syndrome↗
PubMed2004

Renoprotection by blockade of the renin-angiotensin-aldosterone system in diabetic and non-diabetic chronic kidney disease. Specific involvement of intra-renal angiotensin-converting enzyme activity in therapy resistance?

Data of numerous clinical trials show that lowering of blood pressure is prerequisite for reducing the rate of renal function loss in chronic renal disease. There is evidence supporting that blood pressure lowering obtained by intervention in the renin-angiotensin-aldosterone system (RAAS) has an additive renoprotective effect over reduction of blood pressure alone, both in diabetic and non-diabetic renal diseases. The main evidence for renoprotective action of RAAS blockade is provided by its consistent antiproteinuric action, which cannot completely be attributed to the reduction in blood pressure. Indeed, proteinuria reduction during therapy is the single most important factor predicting the renal prognosis, independent from the class of drugs used. Yet, still patients progress to end-stage renal disease. In this review, individual differences in therapy response and possibilities to overcome therapy resistance to RAAS blockade are discussed. Experimental data from studies in rats suggest a specific involvement of intrarenal factors, particularly of preexisting renal damage and renal angiotensin-converting enzyme (ACE) activity, in therapy resistance. Identification of such factors in individual renal patients provides mechanisms by which renoprotective strategies fail to overcome therapy resistance. This prompts for a dual approach to improve renoprotection, namely unravelling these specific intrarenal mechanisms on the one hand, and development of better strategies for early detection of renal risk on the other hand.

Angiotensin Receptor Antagonists↗
PubMed2003

Walking patterns of hip arthroplasty patients: some observations on the medio-lateral excursions of the trunk.

PURPOSE: This study examined the angular gait kinematics of the trunk and the pelvis in the frontal plane and their amount of side-to-side asymmetry in patients after total hip replacement arthroplasty. METHOD: The angular gait kinematics of 12 male hip arthroplasty patients (53-70 years) were compared to ten age-matched and ten young (24-35 years) male control subjects. Average step times and medio-lateral oscillation amplitudes of the pelvic and thoracic recordings were calculated for each step. Between successive steps the asymmetry ratio was computed and the mean angle around which the side-to-side oscillations occurred was compared to the angle in a symmetrical standing trial. RESULTS: ANOVA indicated no significant side differences in relative step cycle durations. Patients and senior controls had significantly (p<0.01) less pelvis side-to-side displacements than the younger controls. No significant between-group differences could be detected for the average asymmetry ratio. However, during walking the patients showed a significantly (p<0.01) increased lateral thorax and pelvis deviation. CONCLUSIONS: Hip replacement patients' thoracic and pelvic position is characterized by a lateral shift throughout the gait cycle, while left and right symmetry of angular movements amplitudes remain at about the same value of unimpaired subjects.

Aged↗
PubMed2003

Neuromuscular control of walking with chronic low-back pain.

The reported association of low-back pain and musculoskeletal disorders contributed to the examination of the lumbar spine and hip extensor activation patterns in back pain sufferers during walking. Seventeen idiopathic low-back pain male subjects and 16 healthy volunteers participated in the study. Hip joint ROMs in the sagittal plane and neuromuscular activities of erector spinae [L3, T12], gluteus maximus and biceps femoris were recorded on one randomly selected body side in each group. Analysis using the Student's t-test revealed significant differences for hip joint range of motion, stride time and significantly earlier onsets of the lumbar spine and hip extensors of the back pain sufferers compared with the healthy controls. It is assumed, that low-back disorders are related to changes of the lumbar spine and hip extensor recruitment pattern.

Adult↗
PubMed2003

[EMG analysis of shoulder muscles during preventive and therapeutic exercise in the overhead athlete].

Strengthening of the rotator cuff muscles in functional positions is one of the important demands in the prevention and rehabilitation of overhead athletes. The purpose of this study was to evaluate the influence of a new shoulder bar (SBT 1000) on the myoelectric activity of the deltoid muscle. Subjects included 12 healthy overhead athletes (control group) and 9 overhead athletes with subacromial pain syndrome (test group). Both groups performed bilateral internal and external shoulder rotations against resistance from a pulley. The position of 90 degrees abduction and elbow flexion was passively supported with the SBT 1000 and had to be actively hold without the SBT 1000. The electromyographic activity of the three heads of the deltoid was determined using surface electrodes. Rectified mean EMG data were analysed by three factor repeated measures ANOVA (group x bodyside x condition). Significant differences (p < 0,05) occurred between the conditions with and without SBT 1000 in all three heads of the deltoid. The percentage of reduction of muscle activity with the SBT 1000 in the dominant arm was 33 %, 29 % and 17 % for the anterior, middle and posterior head. No significant differences could be shown between control and test group or between the dominant and nondominant arm. With the SBT 1000 rotational shoulder exercise can be performed in a functional position with reduced involvement of the deltoid, which could be beneficial in prevention and rehabilitation of overhead athletes.

Adult↗
PubMed2002

Comparison of angular lumbar spine and pelvis kinematics during treadmill and overground locomotion.

OBJECTIVE: To determine the differences between angular oscillation curves of the lumbar spine and pelvis during walkway and treadmill ambulation. DESIGN: An in vivo observation of walking in overground and treadmill conditions. BACKGROUND: Angular movements of the lumbar spine and pelvis have been obtained during overground and treadmill walking. No data are available to indicate whether lumbar spine treadmill findings may be compared or generalized to overground readings. METHODS: Nine male subjects walked at their natural cadence along an 8 m walkway positioned over a motorized treadmill. During each of 20 walking trials, kinematic data of one full gait cycle were collected in the middle segment of the walkway. Following the overground readings the walkway was removed and treadmill recordings were taken at the subjects' preferred walking speed and at an imposed speed of 1.25 m/s. Movement patterns and maximum oscillation angles were calculated in each plane. RESULTS: Cross-correlation values of pairwise comparisons demonstrated almost comparable movement patterns between walking conditions (r > or =0.891; p<0.001) except for the movement in the sagittal plane (r=0.642, p<0.01). ANOVA for repeated measures revealed significant (p<0.05) differences in the gait cycle duration as well as reductions in oscillation amplitudes of the upper lumbar region and the pelvis in both the frontal and transverse plane during treadmill walking compared to walkway locomotion. CONCLUSIONS: Statistically significant differences exist for some angular lumbar spine movement parameters between walkway and treadmill locomotion. RELEVANCE: The observed differences between overground and treadmill locomotion should be taken in account when treadmill-based lumbar spine and pelvis kinematics want to be extended or compared to overground recordings.

Adult↗
PubMed2001

Influences of nonspecific low back pain on three-dimensional lumbar spine kinematics in locomotion.

STUDY DESIGN: A three-dimensional kinematic analysis of lumbar spinal movements with an ultrasonic measuring system was used to distinguish patients with chronic low back pain from those without such pain. OBJECTIVES: To investigate the effects of chronic low back pain on the three-dimensional movements of the lumbar spine, and to identify variables that would allow discrimination among patients with chronic low back pain and control subjects. SUMMARY OF BACKGROUND DATA: To the authors' knowledge, no previous studies have described or identified altered spinal and pelvic gait kinematics caused by nonspecific chronic low back pain in all anatomic planes. METHODS: In this study, 34 participants with chronic low back pain and 22 subjects without such pain were monitored during treadmill gait. Data from the measuring system operating at 30 Hz were low-pass filtered and normalized to a percentage of the gait cycle. RESULTS: Cross-correlations showed almost identical patterns of pelvic (S1) and thoracic (T12) movement curves in all anatomic planes between groups. No statistical group differences were detected for either pelvic or thoracic oscillation amplitudes. However, Student's t test showed significantly higher coefficients of variation (P < 0.01) in all anatomic planes of patients with chronic low back pain than in healthy control patients. CONCLUSIONS: The phasic patterns and angular spinal displacements of patients with nonspecific low back pain were shown to be within normal limits. However, the patients demonstrated higher degrees of stride-to-stride variability, representing increased fluctuations in dynamic thoracic and pelvic oscillations. These findings, resulting in less than optimal gait patterns, must be considered in the rehabilitation of patients with chronic low back pain.

Adult↗
PubMed2001

Sorting and directed transport of membrane proteins during development of hippocampal neurons in culture.

Hippocampal neurons in culture develop morphological polarity in a sequential pattern; axons form before dendrites. Molecular differences, particularly those of membrane proteins, underlie the functional polarity of these domains, yet little is known about the temporal relationship between membrane protein polarization and morphological polarization. We took advantage of viral expression systems to determine when during development the polarization of membrane proteins arises. All markers were unpolarized in neurons before axonogenesis. In neurons with a morphologically distinguishable axon, even on the first day in culture, both axonal and dendritic proteins were polarized. The degree of polarization at these early stages was somewhat less than in mature cells and varied from cell to cell. The cellular mechanism responsible for the polarization of the dendritic marker protein transferrin receptor (TfR) in mature cells centers on directed transport to the dendritic domain. To examine the relationship between cell surface polarization and transport, we assessed the selectivity of transport by live cell imaging. TfR-green fluorescent protein-containing vesicles were already preferentially transported into dendrites at 2 days, the earliest time point we could measure. The selectivity of transport also varied somewhat among cells, and the amount of TfR-green fluorescent protein fluorescence on intracellular structures within the axon correlated with the amount of cell surface expression. This observation implies that selective microtubule-based transport is the primary mechanism that underlies the polarization of TfR on the cell surface. By 5 days in culture, the extent of polarization on the cell surface and the selectivity of transport reached mature levels.

Animals↗
PubMed2001

The application of fetal magnetocardiography (FMCG) to investigate fetal arrhythmias and congenital heart defects (CHD).

OBJECTIVES: Fetal magnetocardiography (FMCG), a new non-invasive diagnostic tool in the analysis of the electrophysiological changes of the heart, was selectively applied in cases of fetal arrhythmias and congenital heart defect (CHD) to demonstrate its value for diagnosis and prenatal management. METHODS: The FMCG was analysed and compared to the postnatal ECG in four cases of fetal arrhythmia [supraventricular tachycardia (two cases), complex tachy-/bradycardia (one case), ventricular extrasystoles (one case)] and a case of right heart hypoplasia diagnosed by established methods prior to investigation. RESULTS: A Wolf-Parkinson-White (WPW) syndrome was diagnosed by its characteristic features and the appropriate transplacental therapy chosen. The types of arrhythmia could be characterised in accordance with postnatal ECG findings and irregular conduction was demonstrated in association with a CHD. CONCLUSIONS: The use of the FMCG provides additional information to the common diagnostic tools that influence therapeutic decisions and thus contributes to optimal pre- and postnatal management.

Adult↗
PubMed2001

Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain.

In a screen for proteins released from synapse-forming spinal cord neurons, we found the proteolytically cleaved N-terminal fragment of a transmembrane protein localized in the postsynaptic membrane of both excitatory and inhibitory synapses. We termed this protein calsyntenin-1, because it binds synaptic Ca2+ with its cytoplasmic domain. By binding Ca2+, calsyntenin-1 may modulate Ca2+-mediated postsynaptic signals. Proteolytic cleavage of calsyntenin-1 in its extracellular moiety generates a transmembrane stump that is internalized and accumulated in the spine apparatus of spine synapses. Therefore, the synaptic Ca2+ modulation by calsyntenin-1 may be subject to regulation by extracellular proteolysis in the synaptic cleft. Thus, calsyntenin-1 may link extracellular proteolysis in the synaptic cleft and postsynaptic Ca2+ signaling.

Animals↗
PubMed2001

[Inline skating in school--perspectives from the sports medicine viewpoint].

INTRODUCTION: Children are motivated by new activities in physical education. Inline Skating (ILS) is one of the trend activities of the last years. For the establishment of ILS in school injury risks and the possible preventive transfer in leisure time activities are of interest. The aim of this study was to compare the incidence of injuries in an ILS-program in school with traditional activities of exercise lessons. Furthermore inline skate specific injury incidence in leisure time was evaluated. METHOD: A sample of 47 schools was evaluated by a standardized questionnaire asking for: injury incidence in traditional sports and ILS and the incidence of ILS-injuries in leisure time. RESULTS: The relative injury risk of ILS (% per 100 teaching units) is 14.3%. Basketball e.g. has an injury risk of 16.1%, handball 14.6%, gymnastics 13.9% and other games 9.5%. After the end of the ILS-program 37.3% of the students reported the incidence of an injury due to ILS in leisure time. CONCLUSION: Compared to other activities in physical education ILS shows a moderate risk of injury and may improve the acceptance of active and passive prophylaxis.

Adolescent↗
PubMed2000

Efficient translation of mouse hypoxia-inducible factor-1alpha under normoxic and hypoxic conditions.

The heterodimeric hypoxia-inducible factor-1 (HIF-1), consisting of the subunits HIF-1alpha and HIF-1beta/ARNT, is a master transcriptional regulator of oxygen homeostasis. Under hypoxic conditions, HIF-1alpha levels very rapidly increase, mostly due to protein stabilization. However, translational regulation of HIF-1alpha has not been directly analyzed so far. Mouse HIF-1alpha exists as two mRNA isoforms (termed mHIF-1alphaI.1 and mHIF-1alphaI. 2) containing structurally different 5'-termini which might modulate translation initiation. Whereas the in vitro translation efficiency of these two mRNA isoforms was about equal, the mHIF-1alphaI.2 5'-untranslated region (5'-UTR) conferred significantly higher in vivo luciferase reporter gene activity than the mHIF-1alphaI.1 5'-UTR. Similar corresponding luciferase mRNA levels indicate translational rather than transcriptional alterations. Reporter gene expression was not affected upon exposure of transiently transfected cells to hypoxia (1% oxygen). Direct assessment of translational regulation by polysomal profile analysis of HeLaS3 cells showed that HIF-1alpha (and to a lower extent ARNT) mRNA was found mainly in the translationally active polyribosomal fractions under both normoxic and hypoxic conditions. In contrast, the association of mRNAs for beta-actin and ribosomal protein L28 with the polyribosomal fractions was substantially reduced under hypoxic conditions, suggesting decreased overall protein synthesis. Thus, efficient translation of mouse HIF-1alpha in a situation where the general translation efficiency is reduced represents a prerequisite for the very rapid accumulation of HIF-1alpha protein upon exposure to hypoxia.

Animals↗
PubMed2000

[Reproducibility of lumbar spine kinematics in clinical gait analysis].

The objective measurement of functional lumbopelvical movements enables the evaluation of the quantity and quality of movements referring to functional disorders in dynamic test-situations. The goal of the present study is the determination of the reproducibility of time-continuous movement analysis of the pelvic region during walking and the determination of possible errors. The movements of the thoracic (Th12), lumbar and sacrum-region (S1) of 17 healthy subjects (age: 32.1 +/- 2.3 years) during walking on a treadmill (4.5 km/h) were investigated twice in an interval of 24 hours by means of a 3D ultrasonic movement analysis system. The ensemble averages of the low-pass filtered and time-normalized angle-time sequences of all anatomical planes and regions showed high test-retest correlations (r > or = 0.92, p < 0.01) except fo the lumbar movement in the sagittal plane (r = 0.79, p < 0.01). A paired t-test showed no significant differences for the amplitudes of test and retest measurements except for the thoracolumbar movement in the sagittal plane (p < .05). The results show that the evaluation of lumbar movement patterns can be regarded as admissible and desirable for clinical movement analysis. The data can be used as a diagnostic tool for the planning and control of therapeutic interventions.

Adult↗
PubMed1999

Neuronal depolarization enhances the transcription of the neuronal serine protease inhibitor neuroserpin.

Neuroserpin is an axonally secreted neuronal serine protease inhibitor. Based on its inhibitory activity towards tissue plasminogen activator (tPA) and its predominant expression in the cerebral cortex, the hippocampus, and the amygdala, a role for neuroserpin in the regulation of neural plasticity has been suggested. We recently found that neuroserpin mRNA is increased in cultured hippocampal neurons upon depolarization with elevated extracellular KCl. Using luciferase reporter constructs containing segments of the promoter region of the neuroserpin gene, we identified a 200-bp segment near the transcription initiation site that is responsible for both the neuron-specific expression of the neuroserpin gene and the enhanced transcription resulting from depolarization. Nerve growth factor, which alone had no effect on the expression of neuroserpin mRNA in hippocampal neurons, had a marked potentiating effect when supplied in combination with elevated extracellular KCl. In contrast, the transcription factor zif/268 blocked neuroserpin transcription. These results implicate neuroserpin as an activity-regulated modulator of tPA activity at the synapse and provide further support for the occurrence of activity-regulated proteolytic processes at the synapse.

Animals↗
PubMed1999

Vascular complications (splenic and hepatic artery aneurysms) in the occipital horn syndrome: report of a patient and review of the literature.

We report an 18-year-old boy with occipital horn syndrome who developed aneurysms of the splenic and hepatic arteries. Occipital horn syndrome, also called X-linked cutis laxa or Ehlers-Danlos syndrome (EDS) type IX, is characterised by a skeletal dysplasia which includes occipital horns, broad clavicles, deformed radii, ulnae and humeri, narrow rib cage, undercalcified long bones and coxa valga. Distinctive features common to all patients are unusual facial appearance, hypermobility of finger joints, limitation of extension of elbows, chronic diarrhoea and genitourinary abnormalities. In this case report we describe the difficulties encountered in the diagnostic management of patients with EDS-related vascular lesions.

Adolescent↗
PubMed1999

Measurement of lumbar spine kinematics in incline treadmill walking.

A study was undertaken to analyse and compare the pelvic (S1) and the trunk (T12) oscillations during level and uphill walking and to provide kinematic baseline data of the lumbar region in incline walking for future comparisons with pathological gait patterns. An ultrasonic movement analysis device (Zebris(R) CMS 50) was used to obtain three-dimensional kinematic data for the pelvis and thorax. Data from treadmill walking at 0 and 10% incline of 22 adults were used for within subject analysis. Crosscorrelation values ranged from r=0.76 to 0.98 (P<0.001) demonstrating a strong degree of agreement between the temporal patterns of angular displacement of the trunk and pelvis in the sagittal, transverse and frontal plane in incline compared to level ambulation. However, Student's t-tests revealed significantly (P<0.01) higher amplitudes for thorax displacements in the frontal and transverse plane in uphill walking. No significant differences were detected for amplitude parameters of the pelvis. It could be stated that the phasic patterns in level walking are not different from that obtained for incline walking. It is concluded that incline ambulation exerts the major influences in the thoracic region by increasing amplitudes of axial rotations.

Adult↗