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Biomedical subjects

L Visconti

Publications and source records attributed to L Visconti.

7 recordsLinked to original sources

HTLV-II/HIV-1 coinfection and risk for progression to AIDS among intravenous drug users.

To determine whether coinfection with HTLV-II influences the course of HIV-1 infection, we evaluated the progression from asymptomatic HIV infection (CDC group II) to persistent generalized lymphadenopathy (CDC group III) to AIDS-related complex (CDC group IVA) to full-blown AIDS (CDC group IVC) to death from AIDS in two groups of HIV-seropositive intravenous drug users (IVDUs). The first group consisted of 123 patients infected with HIV-1 only, and the second comprised 22 patients with serological and molecular evidence of HTLV-II/HIV-1 coinfection. Results of the immunological and clinical follow-up indicated a greater likelihood of developing persistent generalized lymphadenopathy among individuals infected with HIV-1 alone than among those coinfected with HTLV-II. However, no statistical difference was detected between the two groups in the depletion of CD4+ cells, the temporal decrease of the CD4/CD8 ratio, or the progression to ARC or AIDS or to death from AIDS. These findings suggest that HTLV-II may have no effect on the clinical evolution of HIV infection in IVDUs, which may be explained by the lack of pathogenicity of the HTLV-II coinfecting strain(s) and/or other still unclear biological or immunological cofactors or mechanisms.

Acquired Immunodeficiency Syndrome↗

[Mechanical resistance of endodontically treated upper first premolar crowns].

This work shows the results of mechanical strength tests effected over first superior bicuspids before endodontically treated. The Authors show the strength differences, in connection to the access-cavity, between endodontically treated and non-treated teeth. Finally it was found that the demolition of only one marginal ridge reduces the tooth strength to withstand the occlusal forces.

Adolescent↗

Immunological evaluation in children with juvenile chronic arthritis treated with auranofin.

An immunological evaluation was performed before therapy and every four months during the first year of treatment with auranofin in 6 children with juvenile chronic arthritis. The immunological tests included: IgG, IgA, IgM, IgE and "natural" antibody serum levels, CH50 of the classical and alternative complement pathways, PWM-induced IgM production in vitro, and polymorphonuclear neutrophil functions. A reduction of the in vitro IgM synthesis and in the CH50 of the classical pathway of complement, and a normalization of impaired chemotaxis, occurred in patients who presented a clinically significant improvement during auranofin treatment.

Antibody Formation↗

[In vitro study of amalgam corrosion].

AIMS: In the dental field, the aim of the research was to evaluate, through a standardized system, the factors influencing the corrosion of dental alloys in different clinical conditions with various types of amalgams and/or solution parameters. METHODS: A 6-hole corrosion cell was used according to ASTM G5-95 protocol. RESULTS AND CONCLUSIONS: It is well known that free surface corrosion is uncommon in the oral cavity in the case of most dental alloys. But localized corrosion, either as pitting or as crevice corrosion, might occur. The clinical conditions affecting amalgam corrosion may be detectable in localized corrosion, in particular because of cathodic/anodic surface behaviour coupling.

Corrosion↗

Zinc lowers high-density lipoprotein-cholesterol levels.

Zinc administration in rats is associated with a rise in serum cholesterol level. This study examined the effect of zinc administration on serum lipoprotein values in man. Twelve healthy adult men ingested 440 mg of zinc sulfate per day for five weeks. High-density lipoprotein-cholesterol concentration decreased 25% below baseline values (40.5 to 30.1 mg/dL). Total cholesterol, triglyceride, and low-density lipoprotein-cholesterol levels did not change throughout the study. The sharp fall of the "antiatherogenic" lipoprotein, high-density lipoprotein, associated with zinc administration supports the concept that zinc ingestion may be atherogenic in man.

Adult↗