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Biomedical subjects

L Vicentini

Publications and source records attributed to L Vicentini.

At least 55 records · Page 3Linked to original sources
PubMed1986

[Culture from peritoneal drainage as an indicator of active infection].

The present retrospective study reports the results of a survey conducted on 130 patients given elective abdominal and urinary surgery together with the cultivation of routine intraperitoneal drainage material. The parameters considered were the type of pathology, the condition of the wound, any serohaematic material drained, the presence and duration of postoperative temperature increases and pre and post-operative leukocytosis levels. These parameters were considered in relation to the positive or negative results of the cultural examination. The aim was to demonstrate that routine drainage causes no appreciable infective or mechanical complications.

Abdomen↗
PubMed1986

[Serum immunoconglutinin in patients with a respiratory allergy syndrome, before and after specific immunotherapy].

Immunoconglutinins (Ic) are a group of predominantly IgM antibodies formed towards antigenic determinants exposed in fixed complement components (C3b and C4). Ic production is stimulated by bacterial and viral infections; elevated titers were also found in a number of other diseases involving completement-fixing reactions in vivo. High titers have been associated with the infectious morbidity within a particular population. The object of this investigation was to determine the correlations of autostimulated Ic titre with several parameters in 100 atopic nondesensitized subjects with respiratory allergies and in 140 non atopic, healthy, individuals. Eighty of them had rhinitis and/or conjunctivitis, 9 asthma and 11 rhinitis and asthma. All the atopics were studied also after at least 6 months of specific immunotherapy. None of the subjects received any other therapy at the time of study. Atopic subjects with high titers of Ic are significantly more numerous than controls, without significant correlation with the kind and beginning of atopic syndrome, and with immunotherapy. These results might be attributed to a higher incidence of infections in the atopic population. The Ic might play an important role in the immunoregulation involving complement system.

Adolescent↗
PubMed1985

[Non-secretory plasmacytoma. Bibliographic review and immunohistochemical study of a case].

After a brief examination of the recent literature on non-secretory multiple myeloma, the Authors describe the immunohistologic study (peroxidase-antiperoxidase method) of a case of truly non producing plasmacytoma, interesting because of the presence of a small polyclonal plasma cell population within the neoplastic clone. Several possible explanations are considered.

Aged↗
PubMed1985

[Plasma cell leukemia. Bibliographic review and ultrastructural study (by transmission and scanning electron microscopy) in 2 cases].

After a brief examination of the recent literature on plasma cell leukemia, the Authors describe the clinical features and the ultrastructural findings of the peripheral blood plasma cells, examined with transmission (T.E.M.) and scanning (S.E.M.) electron microscopes, of two patients with acute plasma cell leukemia. Both of them had a previous history of myeloma. T.E.M. confirmed the diagnostic value of the asynchronous plasma cells, and S.E.M. showed the characteristic microvilli and blebs, previously observed.

Aged↗
PubMed1984

[Autoantibodies and respiratory allergy: immunologic case study].

Sera obtained from 212 patients with rhinopathy and/or asthma of allergic origin (pollens and/or mites) and from 87 apparently healthy controls were studied for the presence of organ and non organ specific autoantibodies. These were determined by indirect immunofluorescence techniques (5) using test tissue from monkeys (thyroid) and rats (stomach, liver and kidney). Two groups were matched for age and sex and the tests were performed using the double-blind method. The incidence observed was not dissimilar to that detected in healthy subjects, with the exclusion of smooth-muscle antibodies. These were present to a lesser extent in patients with respiratory allergies (0.94%) in contrast with the incidence of 5.73% in normal subjects (P less than 0.01). On the basis of our findings, it seems possible to hypothesize that allergic patients have a lesser tendency to autoimmune diseases because the immune system is committed to the IgE-mediated immunoreactions. In conclusion, autoantibodies do not seem to play a role in the pathogenesis of respiratory allergies to inhaled allergens.

Adult↗
PubMed1983

[Hypocholesterolemia in multiple myeloma. Inverse relation to the component M and the clinical stage].

The following parameters were studied in 41 Durie & Salmon staged patients with multiple myeloma: M component, bone lesions, marrow plasma cell %, Hb, leukocytes/mm3, lymphocytes/mm3, platelets/mm3, blood calcium, serum albumin, blood creatinine, BUN, total blood cholesterol. Linear correlation was adopted for the relation between two variables, using Pearson's coefficient, and Student's t test for unpaired data for comparison between the means. A significant (slight to excellent) inverse correlation was noted between total blood cholesterol and the M component. There was also a significant difference between the 1st and 2nd stage of the disease in this respect (P less than 0.05), between the 1st and 3rd (P less than 0.01), and between the 1st and the 2nd and 3rd combined (P less than 0.01). Progress of the disease appears to result in a fall in blood cholesterol. This parameter may be of assistance in differentiating slow-progressing forms from the more aggressive forms requiring treatment. The reasons for this change are discussed. Since cholesterol is an essential part of the cell membranes, attention is given to theories postulating a disorder in intracellular membrane metabolism.

Blood Platelets↗
PubMed1983

[Prognostic factors and response to chemotherapy in breast cancer. bibliographic review].

The recent literature on prognostic factors in breast cancer was examined with regard to: early or delayed diagnosis, age, menopause, tumour site and size, histological type and grading, involvement of lymph nodes, clinical stage, local recurrence, and distant metastasis. With respect to prognostic factors connected with the response to therapy, the following points were considered: menopause, involvement of lymph nodes, dimensions, clinical stage, free interval, performance and loss of weight, particular sites of metastasis, radiotherapy, oestrogen receptors, prior endocrine management, and certain body fluid parameters (haemoglobin, total lymphocytes, platelets, and white cells, albumin, LDH, SGOT, alkaline phosphatase, blood bilirubin and calcium). Radiotherapy appears to make patients less responsive to subsequent antiblastic treatment, whereas premenopausal status, good psychological and physical efficiency, and prior endocrine management seem to play a positive role in the response to chemotherapy.

Adult↗
PubMed1981

Effects of some GABA-mimetic drugs on the antinociceptive activity of morphine and beta-endorphin in rats.

Intracerebroventricular administration of muscimol, a potent GABA-receptor agonist, counteracted the antinociceptive effect of morphine or beta-endorphin in rats as measured by the "tail flick" method. Muscimol's activity was reversed by bicuculline. Isoguvacine, another GABA agonist, as well as nipecotic acid and guvacine, two inhibitors of neuronal and glial uptake of GABA, also antagonized morphine's antinociceptive effect. A role of the central GABA-ergic system in mediating opiate antinociception is proposed.

Analgesics↗