Biomedical subjects

L Vereczkey

Publications and source records attributed to L Vereczkey.

94 records · Page 6Linked to original sources

PubMedDate not supplied

Pharmacokinetics of vinpocetine (Cavinton) in dog.

The pharmacokinetics of vinpocetine after 10 mg po and iv doses was studied in six beagle dogs treated in cross-over design. The concentration of the drug in plasma was determined by gas-liquid chromatography using N-P FID and capillary column. The elimination half-live and clearance values calculated from time plasma concentration data for iv administration were 8.9 +/- 2.87 h and 4.2 +/- 1.06 1/kg/h, respectively. The bioavailability of the drug was found to be 21.5 +/- 19.3%.

Administration, Oral↗

PubMedDate not supplied

[Some thoughts on Bateman's equation].

The authors have investigated the characteristics of one of the basic equations of pharmacokinetics, Bateman's equation in the function of the differences between the absorption and elimination constants.

Humans↗

PubMedDate not supplied

[Validation of gas and liquid chromatographic methods in the bioanalytical laboratory].

The authors discuss the validation of bioanalytical methods used to generate data for bioavailability, bioequivalence and pharmacokinetics studies. The basis of this manuscript is a consensus on the requirements for bioanalytical validation, which has been reached by a panel of experts at the Washington Conference Report. In this paper it is attempted to suggest approaches to validation parameters both for the method and assay to be evaluated, namely specificity/selectivity, linearity, LOQ/LOD, accuracy, prescision, recovery and stability.

Biological Availability↗

PubMedDate not supplied

Human liver cytochrome P-450 and conjugating enzymes. Hungarian data.

Cytochrome P-450 and the conjugating enzymes of the liver are the most important enzymes in the detoxification of xenobiotics. In order to get direct data in the Hungarian human population the activity of liver cytochrome P-450 enzymes (CYP1A2, 2A6, 2C19, 2D6, E1, 3A4) and of the conjugating enzymes has been determined in 11 Hungarian tissue donors died in accidents or in brain vascular catastrophe, by using specific enzymic reactions. In the activity of cytochrome P-450 enzymes a wide range has been found, a ten-fold difference being rather common. In the activities of conjugating enzymes the differences seem to be less.

7-Alkoxycoumarin O-Dealkylase↗