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Biomedical subjects

L Varga

Publications and source records attributed to L Varga.

At least 91 records · Page 5Linked to original sources
PubMed1990

[Epidemiologic study of primary liver cancer in Vas County].

The incidence of primary liver carcinoma in the last twelve years was investigated retrospectively in the county Vas. A continuously increasing tumor frequency was found, by the end of the period the value had doubled. The phenomenon attained nearly exclusively the male population while no change could be seen in females. For further clarification comparative investigations into the association between chronic HBV infection and chronic alcohol abuse as well and hepatic carcinoma were performed. Changes in these factors cannot fully explain the gross increase in hepatic tumor incidence, the effect of other risk factors has to be suspected.

Aged↗
PubMed1990

[Nicolau syndrome after ketazon injection].

Nicolau syndrome is a rare complication, which occurs after intramuscular injections of various drugs, particularly antirheumatic drugs. During one year, the authors observed this syndrome in three patients, who had received intramuscular injections of Ketazon. The aetiology of the syndrome is not yet known, but it is often caused by accidental intraarterial injections of the drug. Since there is no specific therapy for the syndrome, the authors insist on the possibility of preventing it.

Adult↗
PubMed1990

Different motor actions of dynorphins and nonpeptide kappa opioid receptor agonists in the isolated rat colon.

Dynorphin 1-17 has been suggested to be the endogenous ligand for kappa opioid receptors. In this study motor effects of dynorphin 1-17, its N-terminal fragments d-Pen2,d-Pen5-enkephalin (DPDPE) and d-Ser2-[Leu5]enkephalin-Thr (DSLET) without or with pretreatment with naloxone, (-)-2-(furylmethyl)-noretacocine (Mr 2266) or tetrodotoxin (TTX) on the isolated rat colon were compared with those of nonpeptide kappa opioid receptor agonists. Intraluminal pressure changes were measured by perfusion manometry in preparations maintained in a standard organ bath. Dynorphin 1-17, 1-9, 1-8, 1-6, [Leu5]enkephalin, DPDPE and DSLET dose dependently stimulated the tone in the proximal, middle and distal colon with the maximum response at 10(-6) to 10(-5) M. The stimulation produced by Tyr-Gly-Gly-Phe and Tyr-Gly-Gly was 60 and 600 times less potent, respectively. Concentrations of 10(-10) to 10(-6) M des-Tyr1-[Leu5]enkephalin, dynorphin 3-13, 6-17, 1-methyl-2-(3-thienylcarbonyl)-amino-ethyl-5-(2-fluorophenyl)-H-2,3 dihydro-1,4-benzodiazepine, trans-(+/-)-3,4-dichloro-N-methyl-N-(2-(1-pyrrolidinyl) cyclohexyl)-benzene- acetamide-methane sulfonate and (5a,7a,8B)-(-)-N-methyl-(7-(1-pyrrolidinyl)-1-oxaspiro(4,5)-dec-8- yl) benzeneacet-amide produced no changes in motor activity of the rat colon. Only doses exceeding 10(-6) M of the latter three substances stimulated colonic tone. This action was inhibited neither by naloxone nor by Mr 2266. In contrast, the stimulation by dynorphin 1-17 and 1-6 was inhibited to a greater extent by naloxone than by Mr 2266.(ABSTRACT TRUNCATED AT 250 WORDS)

3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cycloh↗
PubMed1990

Loss of acid suppression during dosing with H2-receptor antagonists.

The suppression of intragastric acidity with H2-receptor antagonists may diminish with repeated administration. To assess the degree and dose-dependence of this tolerance after short-term dosing, two doses of the H2-receptor antagonists, ranitidine (300 mg nocte or q.d.s.) and sufotidine (300 mg or 600 mg b.d.), were given to healthy volunteers for 1 and 2 weeks, respectively. After 1 and 7 days of dosing with ranitidine 300 mg q.d.s. the median 24-h and night-time pH, measured by continuous 24-h pH-metry, dropped from 3.7 to 2.2 and 5.8 to 3.2, respectively (P less than 0.0001 for both). The decline in median pH with ranitidine 300 mg nocte was only significant during the night (from 4.1 to 2.9) (P less than 0.04). There was little change in plasma gastrin concentrations between days 1 and 7 with either dosage. With sufotidine 300 mg b.d. and 600 mg b.d. for 1 and 14 days, the median 24-h pH fell from 3.7 to 2.1 and from 4.6 to 2.6, respectively (P less than 0.0001). The equivalent medians for the night decreased from 6.3 to 2.3 and from 6.6 to 3.1 (P less than 0.0001). Gastrin concentrations did not change after 14 days of dosing with sufotidine 300 mg b.d., but increased significantly during dosing with sufotidine 600 mg b.d. (P less than 0.001). Significant tolerance developed in 7-14 days and it seemed to show some dose relationship. The mechanisms behind tolerance and the role of gastrin are discussed, but remain unclear.

Adolescent↗
PubMed1990

[Giardia lamblia infestation at child day care centers. Nutritional impact in infested children].

Seventy-five children attending a day care center (42 girls and 33 boys, aged from 6 to 65 months) were surveyed for excretion of Giardia lamblia cysts. Cyst excretion was found in 17 (23%) of the children, 9 of whom were still positive 6 months later. Weight, height and arm skinfold thickness of each subject were obtained and compared to normal values in the Québec population; a questionnaire concerning gastrointestinal symptoms was filled out for each child. No difference in weight, height, skinfold thickness or in frequency of gastrointestinal symptoms was found when comparing cyst excretors to children with a negative stool examination. This study suggests that G. lamblia infestation has little or no nutritional impact. This should be confirmed by a larger study.

Age Factors↗
PubMed1990

[Does Campylobacter Helicobacter pylori infection have a clinical relevance? Methodologic, epidemiologic and clinical studies].

The authors searched for Campylobacter pylori (CP) in gastric biopsies from 180 patients by means of microbiological culture. Warthin-Starry staining and urease activity determination. 50 patients with CP-positive antral gastritis were treated with bismuthsubsalicylate 2.4 g per day for 3 weeks, followed by a therapy-free interval of 7-10 days and then a control biopsy was performed. Combined results of bacterial culture and histology proved to be mostly reliable. The prevalence of CP in Hungary is similar to other European countries. CP-positivity was found at the following rates: endoscopically normal patients 30%; stump gastritis 30%; antral gastritis 75%; duodenal ulcer 89%. In all CP-positive cases chronic antral gastritis was seen, whereas normal antral mucosa was never CP-positive. There was no correlation between dyspeptic complaints and CP-positive chronic antral gastritis. Both decreased after bismuth therapy independently on the elimination of CP. CP-positivity in 2/3 of the control investigations points to fast recolonization. The clinical relevance of the CP-infection seems to be questionable.

Adolescent↗
PubMed1989

[Has Campylobacter pylori infection any clinical relevance? Methodologic, epidemiologic and clinical studies].

The occurrence of Campylobacter pylori (CP) was studied in 180 patients referred for endoscopy. The bacterium was detected by culture, histology (Warthin-Starry staining) and urease test of antral biopsy samples. Patient groups were formed according to endoscopic diagnoses, clinical symptoms and antral mucosal histology. 50 CP positive patients with chronic antral gastritis were treated by bismuth subsalicylate (2,4 g/day) for 3 weeks. Positivity by culture and/or silver-stained histology proved to be the most reliable way for detecting CP. CP was proved in about 30% in patients with normal gastroduodenum (13/42) or with stump gastritis (4/15), in 75% with endoscopic antral gastritis (51/68) and in 89% with duodenal ulcer (49/55). A close relationship between CP and histological chronic antral gastritis could be demonstrated. No causal link between CP positive chronic active antral gastritis and non-ulcer dyspepsia could be verified. The decrease in histological activity of chronic gastritis and in dyspeptic complaints after bismuth salt therapy was found to be independent of CP elimination. The results of control investigations following a therapy-free interval of 7-10 days speak in favour of CP recolonialisation within a relativelly short period. It can be concluded that, despite the undeniable relationship between CP and chronic antral gastritis and duodenal ulcer, further studies are necessary to clarify the clinical relevance of the CP infection.

Campylobacter Infections↗
PubMed1989

[Onset of Philadelphia chromosome negative chronic myeloid leukemia with symptoms of intrahepatic cholestasis].

The case of a chronic myelogenous leukemia (CML) starting in an unusual form in a young woman is reported. Rapidly progressing icterus was the first and leading symptom of the disease. Simultaneously with the exclusion of the possibility of hepatitis and extrahepatic obstruction of the bile duct the qualitative blood picture roused the suspicion of a myeloproliferative disease. Detailed hematological examinations confirmed Philadelphia chromosome (Ph1) negative CML. Besides the histologically diffuse leukemic infiltration intrahepatic cholostasis could be demonstrated in the background of the icterus. In the chronic and accelerated phase clinical symptoms developing as a consequence of hepatic organic manifestation were dominating. In the authors's case the moderate leukocytosis, initial thrombocytopenia, absence of splenomegaly, early blast-phase and short survival were atypical, characteristic of Ph1 negative CML. The diagnosis and the absence of other associated hepatopathies was supported also by the post-mortem examination. CML beginning with icteric symptoms due to intrahepatic cholostasis is considered as rarity in the literature.

Adult↗
PubMed1989

[Prognosis of stomach cancer patients in the age of complex diagnostic methods].

A retrospective study was done in 1986-87 on the survival of patients with stomach cancer. Their disease was established with complete diagnostic methods between 1975-87. In 244 patients diagnosis had been set up more than five years before. The survival of these patients was 19.4%, i.e. 47 of them were alive five years after the diagnosis. Both operability and resectability improved when compared to the earlier results (between 1965-74.). The most favourable 5-year survival and resectability were found in patients with intestinal type cancer. Early cancer was 8.3% of total, however, when only those patients were taken into consideration who had been treated either surgically or underwent surgical or endoscopic polypectomy, the percentage markedly increased 22.7%. The survival of patients with early stomach cancer was excellent: 34/37 (91.9%). A significant decrease of the incidence of stomach cancer in the region so far could not be observed.

Gastrectomy↗
PubMed1989

Enprostil reduces the increase of gastric corpus mucosal mass induced by the hydrogen-potassium-stimulated adenosine triphosphatase inhibitor BY 831-78 in the rat.

We studied whether enprostil, a synthetic prostaglandin E2 derivative, might inhibit gastrin release and the trophic effects on gastric oxyntic mucosa induced by prolonged treatment with an inhibitor of hydrogen-potassium-stimulated adenosine triphosphatase, the substituted benzimidazole BY 831-78. Rats were treated intragastrically with enprostil (1 or 15 micrograms/kg b.i.d.), BY 831-78 (15 mumol/kg once daily), the combination of enprostil and BY 831-78, ranitidine (300 mumol/kg b.i.d.), and placebo. Plasma gastrin and somatostatin levels and gastric acid secretion were measured during a 1-day treatment in animals fitted with chronic gastric fistulas and repeatedly during 9 wk of treatment in intact rats. Despite inhibiting acid secretion, enprostil did not increase plasma gastrin. When combined with BY 831-78, enprostil transiently reduced the BY 831-78-induced increase of integrated plasma gastrin (1375 +/- 206 vs. 2137 +/- 256 pmol/L.12 h, p less than 0.05) in fasted rats with fistulas, but failed to prevent the marked hypergastrinemia following 9 wk of treatment with BY 831-78 (717 +/- 80 vs. 731 +/- 56 pmol/L) in intact rats. However, enprostil reduced the BY 831-78-induced increase of oxyntic mucosal volume (458 +/- 31 vs. 567 +/- 33 mm3, p less than 0.01), whereas BY 831-78 prevented the enprostil-induced increase of antral mucosal volume (42 +/- 3 vs. 56 +/- 3 mm3, p less than 0.01). These results demonstrate that some of the trophic effects induced by a hydrogen-potassium-stimulated adenosine triphosphatase inhibitor are not exclusively governed by gastrin.

Adenosine Triphosphatases↗
PubMed1989

Smoking and pH response to H2-receptor antagonists.

Smoking has been shown to impair the therapeutic effect of H2-receptor antagonists. To evaluate the acid-reducing capacity of H2-receptor antagonists in relation to smoking habits, we tested the effect of ranitidine (Ran) and famotidine (Fam) under physiologic conditions, using ambulatory pH-metry. Intragastric pH was measured over 20 h. Each of 18 healthy volunteers, 9 smokers and 9 nonsmokers, received 40 mg Fam, 300 mg Ran, or placebo in a double-blind, randomized study as a single evening dose. With both drugs 20-h acidity was markedly suppressed. After Fam treatment mean inhibition was 61% in smokers and 76% in nonsmokers and after Ran 51% and 67%, respectively. When areas under the pH curves for each individual were calculated and treatment compared with placebo (= 100%), the response was smaller in smokers than in nonsmokers with either drug (Fam, 153 +/- 21% versus 214 +/- 19%, p less than 0.01; Ran, 176 +/- 21% versus 232 +/- 29%, p less than 0.05) during the first 4 h after drug intake. A similar effect was observed in the morning period from 0600 to 1000 h (Fam, 118 +/- 19% versus 206 +/- 19%, p less than 0.001; Ran, 133 +/- 21% versus 207 +/- 31%, p less than 0.02). During the nighttime there were no significant differences. These findings indicate that smoking impairs the response to both drugs tested.

Adolescent↗
PubMed1988

Patients with CLL and hypocomplementaemia have an impaired serum bactericidal activity against the Salmonella minnesota Re mutant.

The bactericidal effect of 25 serum samples from 23 patients with chronic lymphocytic leukaemia (CLL) against the Salmonella minnesota S form and Re mutant has been studied. No killing of the S form was observed in any of the sera tested, whereas a normal bactericidal effect was found against the Re mutant (group 1) in 17/25 sera of CLL patients. By contrast, in 8 serum samples from 6 CLL patients no killing or a markedly delayed killing of the Re strain was observed (group 2). Significant differences in the complement levels were found between the sera of group 1 and group 2. In group 1 mostly normal or elevated complement levels were observed, while in group 2 levels of C4 and C2 were found to be strongly decreased. A significant correlation was found between the bactericidal effect on the one hand and the C4 and C2 levels on the other.

Blood Bactericidal Activity↗
PubMed1988

BSA-anti-BSA immune complexes formed in the presence of human complement do not bind to autologous red blood cells.

The binding of 125I-BSA-anti-BSA immune complexes (IC) formed in the presence of complement (nascent IC) and those that reacted with complement after their formation (preformed IC) to human erythrocytes was studied. The effect of antigen-antibody ratios and serum dilutions on IC binding to red blood cells (RBC) were also investigated. A dramatic difference was found between the behaviour of the two types of complexes: while preformed IC bound effectively to human RBC after their interaction with complement, no efficient RBC-binding was observed with nascent BSA-anti-BSA complexes formed in the presence of complement. Changing the antigen-antibody ratio or dilution of serum did not affect markedly the extent of difference between the binding of preformed and nascent IC. Our findings do not support the essential role of red blood cells in the elimination of each type of IC.

Animals↗
PubMed1987

C1 and C4 abnormalities in chronic lymphocytic leukaemia and their significance.

Clinical and laboratory correlations of low C1 and C4 levels previously found to be a characteristic feature of chronic lymphocytic leukaemia (CLL) were analysed. Abnormalities of C4 were restricted to stage 1, 2 and 3 of CLL, whereas in the more advanced disease (stage 4) only low C1 levels were found. It was demonstrated that the observed disorders were associated with an increased susceptibility of the patients for infections and impair the immune complex precipitation inhibiting capacity of the patients' sera as well.

Antigen-Antibody Complex↗
PubMed1987

Synthesis and biological activity of some glucose-enkephalin conjugates.

Two O-glucopeptides, H-Tyr(beta-D-Glc)-Gly-Gly-Phe-OH(10) and H-Tyr(beta-D-Glc)-Gly-Gly-Phe-Leu-OH (11), having the amino acid sequence of enkephalin, were synthesized to determine the influence of the carbohydrate molecule on the biological activity and conformation of these opioid peptides. The synthesis were carried out in a stepwise and/or direct manner by fusing the activated O-glucosylpseudourea intermediate with suitably protected amino acid or peptide derivatives, followed by hydrogenolytic removal of protecting groups. The pure compounds were tested for opiate-like activity by using the guinea pig ileum (GPI) and mouse vas deferens (MVD) preparations.

Animals↗
PubMed1987

Study of the immune complex precipitation-inhibiting capacity of sera of patients with chronic lymphocytic leukaemia.

Two procedures measuring the capacity of different sera to prevent the precipitation of nascent immune complexes were compared: a kinetic method with a constant immune complex/serum ratio and a new procedure--the increasing immune complex load method--using different immune complex/serum ratios. Immune complex precipitation inhibition is known to depend on complement. The sera of 25 patients with chronic lymphocytic leukaemia (CLL) and the sera of nine healthy blood donors were compared with the two procedures. The kinetic method discriminated poorly between the patients' sera and the control sera, whereas the increasing immune complex load method showed a highly significant difference between the two groups. Sera with low C4 level had the lowest immune complex precipitation-inhibiting activity. Interestingly, however, in the increasing immune complex load method not only hypocomplementaemic but also normocomplementaemic sera from CLL patients were found to be markedly defective. This finding suggests that the CLL patients' sera contain a factor which modulates complement-dependent inhibition of immune complexes.

Antigen-Antibody Complex↗