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Biomedical subjects

L Valentin

Publications and source records attributed to L Valentin.

97 records · Page 6Linked to original sources
PubMedDate not supplied

Transvaginal Doppler examination of uteri with myomas.

The uterine arteries and arteries in the wall and core of myomas were examined with transvaginal color and spectral Doppler ultrasound in 28 premenopausal and 17 postmenopausal women with uterine myomas. Eighteen premenopausal women and 100 postmenopausal women without myomas served as the controls for uterine artery Doppler measurements. The respective median time-averaged maximum velocity and pulsatility index (PI) values for the left uterine artery were 36.1 cm/s and 1.36 in premenopausal women with myomas vs. 17.6 cm/s and 2.58 in controls; p = 0.0001. The corresponding values in postmenopausal women were 13.9 cm/s and 1.93 vs. 11.0 cm/s and 2.33; p < 0.05. PI values < 1.0 were recorded from 92% (24/26) of the myomas in premenopausal women and from 69% (11/16) of those in postmenopausal women. We conclude that uterine myomas substantially affect blood flow velocity in the uterine arteries, and that PI values < 1.0 are common in uterine myomas and do not indicate malignancy.

Adult↗
PubMedDate not supplied

Early amniocentesis and congenital foot deformities.

OBJECTIVE: Several studies have shown an increased risk of congenital foot derformities after early amniocentesis. These studies have comprised amniocenteses performed before 13 completed gestational weeks. In this study, the risk of foot deformities after amniocentesis performed at 12-14 completed gestational weeks was determined. METHODS: 3,469 genetic amniocenteses in singleton pregnancies performed before 15 completed gestational weeks were studied. The intention was to perform the amniocenteses at 12-14 weeks of gestation, but 32 amniocenteses were performed at the gestational age 11 weeks + 5 days or 11 weeks + 6 days. The pregnancies were followed up with regard to fetal loss and leakage of amniotic fluid. After birth, newborns with a diagnosis of foot deformity were identified from the Swedish Medical Birth Registry. The observed number of foot deformities was then compared with the expected number which was calculated stratified for delivery hospital, year of birth, and maternal age. RESULTS: The observed number of foot deformities was significantly higher than the expected: exact odds ratio 1.74 (exact 95% confidence interval 1.06-2.69). The rate of spontaneous abortions after the procedure was 1.8%, and the rate of leakage of amniotic fluid was 1.9%. There was a significant trend for all complications to decrease with increasing gestational age at amniocentesis. CONCLUSION: Women undergoing amniocentesis at 11+5 to 14+6 gestational weeks have an increased risk of giving birth to a child with a congenital foot deformity.

Abortion, Spontaneous↗
PubMedDate not supplied

Recording of foetal movements: a comparison of three methods.

As decreased foetal movement (FM) may indicate impaired foetal health, FM recording has been suggested as a method of assessing foetal well-being. A non-intrusive, automated method of recording FM (FM-detector), was compared with maternal and ultrasonographic assessment of FMs in 24 women in the third trimester of pregnancy. The FM-detector detected a greater proportion of ultrasonographically recorded FMs than the mothers did (median 70% and 38%, respectively; p less than 0.001). Parity, gestational age, placental site or thickness, maternal weight or the distance from the maternal abdominal surface to the amniotic cavity did not affect the ability of the FM-detector to detect ultrasonographically recorded FMs. The estimation of FM strength by the FM-detector agreed fairly well with the assessment of FM strength by the ultrasound observer. The FM-detector would seem suitable for clinical use, as in the examination of pregnant women complaining of feeling 'less FM'.

Adult↗