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L V Il'ina

Publications and source records attributed to L V Il'ina.

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[Ligand-induced structuring of polyreactive immunoglobulins].

The influence of several hydrophobic compounds with different structures on the binding of native and chaotropically modified bovine immunoglobulins to native and denatured nonspecific protein immobilized on the surface is researched. It is shown that the character of binding depends on the amount and mutual location of hydrophobic nuclei in the effectors structure. The authors observed moderate suppression of binding or absence of the expressed effect while using one-nucleus effector. The influence of compounds with two distanced benzene nuclei differs qualitatively from the influence of the compound with two condensate ones, described earlier: it was observed that the stimulation level of the binding depends on structural-functional condition of immunoglobulin and immobilized protein. In case of the effector with three spaced hydrophobic nuclei the stimulating effect is much more expressed (3-4 times higher). The concentration dependence of the ligand-induced effects is demonstrated. It is supposed, that stimulative influence of effectors with spaced hydrophobic nuclei is caused by two different processes. The first one is the formation of highly binding center as the result of ligand-induced structuring of immunoglobulins. The other one is the competition for the center formed between dissolved polynuclear effector and ligand groups of aminoacids hydrophobic residues statistically formed on the surface of immobilized protein.

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[Changes in the amine oxidase activity of human serum during different types of anesthesia and hyperbaric oxygenation].

Some types of anesthesia, used usually in labor anesthesia (sodium hydroxybutyrate, lexir) or in abdominal delivery (neuroleptanesthesia, cetalar narcosis, electroanesthesia) did not affect distinctly the activity of amine oxidases in blood sera of women in labor and of fetus. In some groups of women in labor the neonates were found, blood serum of which exhibited high activity of diamine oxidase, not observed in normal state. A slight decrease in deamination of benzylamine (20%) and 4-nitrobenzylamine (30%) was observed in patients with gynecological diseases within 2 and 3 days after operations. If intestinal paresis developed in the patients within the postoperational period deamination of these substrates was decreased by 75-80% in blood sera. After 2-4 courses of hyperbaric oxygenation a slight but statistically distinct decrease (by 22-25%) in the rate of deamination of benzylamine and 4-nitrobenzylamine was found in blood sera of the patients.

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