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Biomedical subjects

L V Devoĭno

Publications and source records attributed to L V Devoĭno.

At least 19 recordsLinked to original sources
PubMed2005

[The role of D1 and D2 dopamine receptors of the rat nucleus accumbens in immunostimulation].

The analysis of the immune response changes in Wistar rats has shown that bilateral electrolytic lesions of the nucleus accumbens characterized by a high density of D1 an D2 dopamine (DA) receptors resulted in a decrease of the immune response to SRBC. Administration of selective agonists of D1 and D2 DA receptors to sham-operated animal: 20 mg/kg of SKF 38393 or 1.0 mg/kg of quinpirol, respectively, produced significant enhancement of plaque- and rosette-formation. However, the immune response level in the damaged rats did not increase following quinpirol administration, but was maintained at control values, rather. At the same time, activation of D1 DA receptors in rats with destructed nucleus accumbens did not affect the immune response level as compared to that of sham-operated animals receiving SKF 38393. The data obtained give evidence of involvement of D2 DA receptors of the nucleus accumbens in immunomodulation, although D2 DA receptors of other brain structures may also contribute to this process. D1 DA receptors of this localization seem not to play any important role in the immune response control.

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-ben↗
PubMed2004

[Contribution of D2 dopamine receptors of the rat dorsolateral caudate nucleus to immunomodulation].

The analysis of the immune response changes in Wistar rats under activation or blockade of D2 DA receptors has shown that electrolytic lesion of the dorsolateral caudate nucleus characterized by a high density of D2 DA receptors resulted in a decrease of the immune response to SRBC. At the same time, in rats with similar lesion stimulation of the immune reactions caused by a selective D2 agonist guinpirol (1.0 mg/kg) did not develop completely. Administration of haloperidol (2.0 mg/kg), the immune-inhibitory effect of which is associated with increasing serotoninergic system activity, to rats with impaired dorso-lateral caudate nucleus did not produce more expressed immunosuppression. However, the level of the immune response in sham-operated rats receiving haloperidol was significantly lower than that of animal with the destructed nucleus caudatus. Considering that qunmpirol-induced immunostimulation is related to the selective activation of the DA-ergic brain system, it is concluded that D2 DA receptors of the nucleus caudatus are involved in the mechanisms of immunostimulation, although D2 DA receptors of other brain structures may also impact this process.

Adjuvants, Immunologic↗
PubMed2002

[Distribution of serotonin and its metabolites in the brain structures and immunosuppression in submissive mice].

The development of submissive behaviour in C57BL/6J mice in the sensory contact model was associated with an increase in the content of serotonin (5-HT) in the amygdala, hippocampus, dopaminergic nuclei A11, A10, A9, as well as in the caudate nucleus and hypothalamus after 10 and 20 days of confrontations compared to the controls. The level of 5-HT metabolite 5-hydroxyindolacetic acid (5-HIAA) was significantly higher in the most structures examined after 20 daily encounters as compared to animals with experience of 10 confrontations. The time course of submission over 10 or 20 days resulted in an increase of 5-HIAA/5-HT ratio in the midbrain nucleus raphe, nucleus accumbens, A9 and hypothalamus. In mice immunised on the 10th or 20th day of confrontations, the immune response inhibition was observed while its level remained unchanged after more prolonged confrontations (40 days). Thus, the experience of defeats during 10 days shown to be accompanied with an activation of 5-HT system in a number of the brain structures, produced immunosuppression. With increasing number of confrontations the ratio 5-HIAA/5-HT was decreased in the same structures and a tendency to the immune response elevation appeared.

Animals↗
PubMed2002

[Activation of dopaminergic system stimulates an immune response in mice with opposite type of behaviour].

It was shown that activation of dopaminergic (Daergic) system induced an increase of the immune responsiveness independent of the CBA mice behaviour typeanimals without experience of victories and defeats (control), with aggression and submission. Administration of SKF-38393, a selective agonist of DA D1-receptors, resulted in enhanced immune response as tested by plaque-forming cells and rosette-forming cells number. Similar immunostimulation was observed after injection of p-chlorophenylalanine realizing its influence on the immune response through DA D2-receptors as shown by us elsewhere. It was suggested that activation of Da-ergic system produces a new neurochemical pattern (Daergic neurochemical set) which are responsible for character and intensity changes of the immune response in mice with alternative form of social behaviour.

Aggression↗
PubMed2000

[Participation of the rat caudate nucleus in the immunostimulating effect of DAGO].

The data obtained suggest that administration of the DAGO increased the number of plaque- and rosette-forming cells after immunisation with the sheep red blood cells in the sham-operated Wistar rats. Following destruction of the caudate nucleus, the DAGO administration prevented the immune activation. Bilateral destruction of the caudate nucleus resulted in a considerable inhibition of the immune response as compared with the control rats. Thereupon the caudate nucleus seems to be involved in realisation of the DAGO-induced immune activation.

Adjuvants, Immunologic↗
PubMed1999

[Immune responses in C57BL/6J mice with the inverted pattern of behavior during social conflict].

Inversion of aggressive behaviour into a submissive one led to immunosuppression in C57BL/6J mice as well as in those mice which did not change their behaviour, whereas inversion of submissive behaviour into aggressive one resulted in immunostimulation. A possibility to influence immune response changing the brain neurochemical pattern by reversing behaviour under conditions of a social conflict, is discussed.

Aggression↗
PubMed1998

[The neurochemical set of the brain--an extra-immune mechanism of psychoneuroimmunomodulation].

The present study provides evidence for involvement of brain neurotransmitters in the control of an immune response. The extra-immune mechanism of immunomodulation is considered by analyzing drug-induced changes in the brain neurotransmitter systems, brain destruction, altered activity of brain regions due to psychoemotional stress, including mental disease. It is suggested that the pattern of neurotransmitter activity with its prevalence in certain brain regions determines the neurochemical set-up of the brain for psychoneuroimmunomodulation, i.e. its extra-immune mechanism.

Animals↗
PubMed1993

[The serotonin-dependent suppression of the immune response by kappa-opiate receptors].

The modulating effect of the kappa-opiate agonist, rimorphin, on the immune response was studied. This opioid in all the doses tested (1, 10 and 100 mkg/kg) was found to cause inhibition of the immune reaction as compared to the control CBA mice which received saline only. The dissection of the pituitary stalk prevented the inhibitory effect of rimorphin on the immunity. The opioid-induced immunosuppression was shown to be due to interaction with the serotoninergic system since it had no effect after preliminary blockade of S-2 serotonin postsynaptic receptors with cyproheptadine.

Animals↗
PubMed1993

[The normalization of the immune response in old stressed mice by apomorphine].

It has been shown that the immune reactivity of old C57BL/6 mice aged 24-27 months immunized with sheep red blood cells (5 x 10(8)) was decreased as compared to young mice (2-3 months). Activation of the dopaminergic system by the agonist of dopamine postsynaptic receptors apomorphine resulted in normalization of an immune response in old mice. Injection of apomorphine also prevented the immunosuppression observed in old mice, which was induced by immobilization stress (3.5 hours on the back). Immune response level of these animals approached that of young nonstressed animals. It was suggested that disturbance of the mechanisms of psychoneuroimmunomodulation in old and stressed animals could be prevented by changing the neurochemical pattern of the brain.

Aging↗
PubMed1991

[Changes in the immune response of male mice with aggressive and submissive types of behavior].

An increase in the number of rosette- and plaque-forming cells occurred in aggressive CBA mice whereas the immune response of aggressive animals of another strain (C57BL) did not differ from control values after experiencing 10 fights. The immune response was considerably reduced in submissive C57BL mice under the same conditions. Common neuro transmitter links of the regulation of aggressive and submissive behaviour and immunomodulation, are discussed.

Aggression↗
PubMed1990

[The role of the hypophysis in the immunomodulating influence of the GABA-ergic system].

In CBA mice immunized with the sheep red blood cells (5 x 10(8)), the section of the pituitary stalk prevented the changes in the immune response caused with drugs affecting the activity of GABA-ergic system. Activating effect of the benzodiazepine receptor agonist diazepam, and inhibitory effect of bicucullin on the immune response were not manifest in animals after the lesion of the hypothalamo-pituitary stalk. The mechanism of increasing of the L3T4 T-helpers in bone marrow under the effect of GABA-ergic system activity was also actualized through the hypophysis. The central GABA-ergic mechanisms of the neuroimmunomodulation are discussed.

Animals↗
PubMed1990

[Changes in the level of dopamine and its metabolites in brain structures and immunocompetent organs in the formation of immune response].

By the method of liquid chromatography with electrochemical detection dopamine level increase was shown within 2 min after immunization of rats with sheep red blood cells in n. caudatus. In 20 min after the immune response the acceleration of dopamine metabolism was observed in nuclei A9, A10, A11, accumbens, in amygdala, hypothalamus and hippocampus. In immunocompetent organs dopamine level was changed in 24 h after the immunization.

Adrenal Glands↗
PubMed1988

[Interaction of the GABA-ergic system with the dopaminergic and serotoninergic in immunomodulation].

In CBA mice immunized with sheep red blood cells, the GABA-ergic system was found to act on the immunogenesis depending on the monoaminergic systems activity. The dopaminergic system stimulating immunogenesis is predominant in activation of the GABA-ergic system, whereas the serotoninergic system mediating the inhibition of the immune response is predominant in conditions of the GABA-ergic system blockade.

Adjuvants, Immunologic↗
PubMed1988

[Action of benzodiazepines on the immune response].

The action of benzodiazepine receptor agonists--diazepam and tazepam--on the immune response was studied in CBA mice. It has been shown that benzodiazepine at low doses of 0.5 and 1 mg/kg stimulates and at a dose of 8 mg/kg suppresses the rosette-forming reaction to immunization with 5 X 10(8) sheep red blood cells. Diazepam and tazepam fail to change the immune response if the immunization dose is 5 X 10(6). The dose-dependent effect of diazepine (ranging from stimulation to inhibition) may be caused by different benzodiazepine receptors involved in the process. It is suggested that a certain intensity of the immune response is needed for the manifestation of the immune modulating action of benzodiazepine.

Animals↗