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Biomedical subjects

L Trulsson

Publications and source records attributed to L Trulsson.

At least 19 recordsLinked to original sources
PubMed1999

Survival of human parathyroid tissue xenotransplanted in nude mice after 9 to 55 months' cryopreservation.

Survival of human parathyroid tissue xenotransplanted after cryopreservation was studied. Peroperative biopsies from 26 patients were cryopreserved and xenotransplanted into nude mice after 9 to 55 months. At 8 to 12 weeks after transplantation, the morphology of the transplanted tissue was compared to that of the original tissue after thawing and before transplantation. Morphologically viable tissue was observed in 20 out of 26 nude mice (77%). Based on the morphological appearance, the parathyroid transplants were arranged into four "quality" groups. No correlation existed between the quality of the transplants and duration of storage, or between the age and sex of the patients. There was no correlation between initial clinical diagnosis or histopathological patterns (primary, secondary and tertiary hyperplasia [n=16], adenoma [n=9], one case undetermined) and transplant survival. After thawing and transplantation, all parathyroid grafts, except one, were morphologically either of the same or somewhat lower quality.

Adenoma↗
PubMed1994

Dermatitis with an unusual explanation in a welder.

Occupational diseases among welders include asthma, acute keratoconjunctivitis, and various skin disorders. A localized cutaneous erythema from UVC radiation is common and does not generally constitute any problem, as its cause is obvious to the welder, the symptoms are slight, and it is transient. In this report a welder with UVC-induced erythema on the cheeks is described. Initially, neither the worker, the physician at the factory, nor ourselves suspected a UVC erythema. Extensive investigations, including factor visits with measurements of UVA, UVB, and UVC irradiance during welding, revealed the cause of the dermatitis to be UVC, most likely reflected from a textile hood used to prevent exposure to dirt.

Adult↗
PubMed1990

Allergic contact dermatitis from diphenylthiourea in Vulkan heat retainers.

11 cases of contact dermatitis from Vulkan heat retainers are reported. The skin eruptions started on days 1-11 after the 1st day of exposure. The clinical picture varied from eczema through urticaria to purpura. In some cases, the symptoms were severe. Patch testing was performed in 10 individuals and all reacted positively to the heat retainer and/or the rubber glue used in the heat retainer. A series of rubber chemicals was patch tested in 7 patients and all showed positive reactions to diphenylthiourea (DPTU), and all but one to ethylene thiourea (ETU). TLC examination revealed a spot with the same RF-value as DPTU in extracts of the adhesive, but no spot corresponding to ETU. There were no indications of impurities in the test preparations of DPTU and ETU. By HPLC, the content of DPTU in the adhesive was determined as 0.6% w/w.

Adhesives↗
PubMed1986

Demonstration of contact sensitizers in resins and products based on phenol-formaldehyde.

12 phenol-formaldehyde resins were investigated with regard to the presence of 14 contact sensitizers by using high-pressure liquid chromatography. The allergens consisted of simple methylol phenols, dihydroxydiphenyl methanes, 4,4(1)-dihydroxy-(hydroxymethyl)-diphenyl methanes and 2,4(1)-dihydroxy-(hydroxymethyl)-diphenyl methanes. Four substances, 2,4-dimethylol phenol, 2,6-dimethylol phenol, 4,4(1)-dihydroxydiphenyl methane and 2,4(1)-dihydroxydiphenyl methane, were isolated from a resol resin and identified by mass-spectrometry and nuclear magnetic resonance spectrometry. The highest concentrations (up to 15% w/w) of allergens were noted for methylol phenols in resol resins based on phenol and formaldehyde. The corresponding novolak resins showed a high content of dihydroxydiphenyl methanes. There was great variation in concentration of the sensitizers between the resins. None of these sensitizers were demonstrated in the resin based on paratertiary-butyl phenol. Products based on phenol-formaldehyde resins were also investigated for the presence of allergens. Uncured impregnated paper for laminate production and uncured mineral wool contained the same concentrations of the sensitizers as some of the resins studied. The curing process decreased the content of all the allergens investigated in all products, but the sensitizers did not disappear, and they may thus be present in finished products.

Allergens↗
PubMed1984

An attempt to isolate and identify allergens in lanolin.

One sensitizer, a sterol, has previously been reported to be present in lanolin. In this study, a related substance, a sterol, with a molecular weight of 424 has been isolated. A few sensitive subjects did not react to this substance. Lanolin probably contains several sensitizers. Sensitization to lanolin in guinea pigs seems previously to have failed. In this study, a methanol extract of a lanolin preparation containing large amounts of sterols sensitized guinea pigs.

Allergens↗
PubMed1984

Contact allergy to styrene and related chemicals.

One patient, sensitive to styrene, cross-reacted at patch testing to 2-,3-and 4-vinyltoluene (2-,3-and 4-methylstyrene) and to the metabolites styrene epoxide and 4-vinylphenol (4-hydroxy-styrene). It is assumed that styrene is a prohapten metabolized in the skin by aryl hydrocarbon hydroxylase (AHH) to styrene epoxide acting as the true hapten. Styrene occurs in nature and as a synthetic product. Vinyltoluenes (methylstyrenes) occur as synthetic products in plastics. 4-vinylphenol (4-hydroxystyrene) occurs frequently in different ciders, wines, foods and berries, e.g. cloudberry.

Dermatitis, Atopic↗
PubMed1984

Contact dermatitis from the epoxy resins tetraglycidyl-4,4'-methylene dianiline and o-diglycidyl phthalate in composite material.

An outbreak of dermatitis occurred in an aircraft factory using epoxy resin composite material. Of 25 operatives, 14 gave positive patch test reactions to the composite material and/or diglycidylether of bisphenol A (DGEBA), tetraglycidyl-4,4'-methylene dianiline (TGMDA), and o-diglycidyl phthalate. This report seems to be the first to demonstrate contact allergy to the two last mentioned epoxy resins. The diglycidylether of bisphenol A used in routine test series picked up only 3 cases of 12 tested.

Aniline Compounds↗