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Biomedical subjects

L Trnka

Publications and source records attributed to L Trnka.

At least 73 records · Page 4Linked to original sources
PubMed1979

Immunoprofile studies in patients with pulmonary tuberculosis. III. Study of haemolytic complement in serum and phagocytic activity of blood neutrophils.

The total level of haemolytic complement in serum, and the phagocytic activity of blood neutrophils were found to be significantly increased in patients with active pulmonary tuberculosis prior to treatment. A relationship could not, however, be demonstrated between the elevation in the two studied values and the extent of tuberculous changes in the lungs of the patients.

Complement System Proteins↗
PubMed1979

Immunoprofile studies in patients with pulmonary tuberculosis. IV. Tuberculin skin reaction and test of inhibition of blood leukcoyte migration.

Study of the relationship existing between in vivo and in vitro correlates of cell immunity has revealed that there is no marked correlation between the magnitude of skin induration of the tuberculin skin test and the degree of inhibition of migration of blood leukocytes stimulated by PPD in patients with newly detected, bacteriologically confirmed pulmonary tuberculosis.

Cell Migration Inhibition↗
PubMed1976

Influence of immunosuppression on the action of antimycobacterial drugs in experimental tuberculosis. I. Effects of isoniazid, rifampicin and streptomycin on the survival of tuberculous mice immunosuppressed by azathioprine (Imuran).

The influence of the host immunosuppression on antimycobacterial effects of isoniazid, rifampicin or streptomycin was studied on animal models. Differences in survival rates of mice influenced or uninfluenced by azathioprine (Imuran) and exposed to six applications of antituberculous drugs (given once a day in the monotherapy) were statistically evaluated. The dose-dependent antimycobacterial effects of rifampicin or isoniazid were not significantly altered by the immunosuppression of the host. In contrary to that definite dose-dependent effect of streptomycin, observed in azathioprine-uninfluenced mice, cannot be confirmed in immunosuppressed mice in which no effect of streptomycin on the survival of tuberculous mice could be estimated.

Animals↗
PubMed1975

Specific acquired resistance and activity of migration inhibition factor (MIF) in spleens of mice with chronic tuberculosis.

The antimycobacterial resistance of the host (as evaluated by mycobacterial counts in spleens) and the in vitro cell-mediated immunological mechanisms ((cellular immune reactivity) assayed by the activity of migration inhibition factor in splenic fragments) were compared in the course of experimental chronic tuberculosis infection. Mice, either unvaccinated or vaccinated with killed mycobacteria suspended in saline and then either untreated or treated with azathioprine, were used in the study. The treatment with azathioprine caused a relative depression of specific resistance accompanied by less pronounced inhibition of migration in vitro. Although a higher level of specific resistance was detected in mice vaccinated with non-living vaccine, no enhancement of cellular reactivity in vitro could be estimated in the splenic cells of these animlas. The participation of humoral mechanisms in mice vaccinated with the non-living vaccine plausibly explains the discrepancy. The results indicate furthermore, that the migration inhibition test reflects delayed hypersensitivity rather than other components of cellular immune reactivity.

Animals↗