Biomedical subjects
Publications and source records attributed to L Traissac.
The Galen's anastomosis connects superior and recurrent laryngeal nerves and its anatomy and physiology still remain unknown. In humans it can be found in 30 to 60% of cases, according to classical anatomy books. In this study the authors report the anatomy of 47 fresh half-larynx. They have demonstrated the invariable existence of an anastomosis between superior and recurrent laryngeal nerves, either as a single nerve, or as a plexus.
To further knowledge of the laryngeal nerves, the nerve fibers of Galen's anastomosis were studied using two neuroanatomical methods, namely nerve degeneration and horseradish peroxidase labeling. It is demonstrated that the superior laryngeal nerve forms part of the tracheal and esophageal nervous system. The value of the results in relation to physiological laryngeal studies and to human laryngeal diseases is discussed.
Laryngeal reinnervation procedures were performed on 15 dogs. An anastomosis was performed between a selected motor branch of the ansa hypoglossi and the posterior cricoarytenoid nerve. The results were analyzed endoscopically, electromyographically, and histologically. Results were satisfactory in 12 cases. The methods and results have been compared with those obtained using other reinnervation techniques.
Two hundred and forty-one patients, with advanced squamous cell carcinoma of head and neck, were randomized to receive three courses of induction chemotherapy. The chemotherapy regimens were delivered every 3 weeks, and consisted in 1) cisplatin, 80 mg/m2 given alone (CDDP regimen), or 2) in combination with vincristine, 1 mg, d 1, methotrexate 10 mg/m2 d 1, 2, 3, and bleomycin 10 mg/m2, d 1, 2, and 3 (MOB-P). Tolerance was significantly better with the CDDP regimen (p less than 0.05); severe side effects, affecting mainly digestive tract, and bone marrow, were encountered in 7% of the patients in the CDDP group, vs 15% in the MOB-P group, without death related to pancytopenia. Short-term results were better for patients treated by the MOB-P regimen, with a 42% response rate (including 9 complete responses) vs 22% with the CDDP regimen (p = 0.01). A superiority of combination chemotherapy was more significant for primary sites than regional lymph nodes. The relapse-free survival was not statistically different in the 2 groups, as well as the 2 years overall survival. Among responders, the survival was found highly correlated with a good initial general status (p less than 0.01), and with the highest total doses of cisplatin (p less than 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)
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Performance of a voice prosthesis, used to restore speech in patients following total laryngectomy, was evaluated by measuring in vitro, as well as in vivo, airflow resistances. The pressure-flow characteristics of the device were analyzed using the standard pressure-flow diagram (to calculate airway resistance) and a Moody plot (to determine the different flow patterns). The flow rate and the pressure drop were measured with a Fleisch pneumotachograph and a variable reluctance transducer, respectively. Total device resistances were found in the range of 34-50 cm H2O/L/s when the flow-rates ranged from 0.05 to 0.35 L/s. Comparison of these resistances with those of other commercially available devices showed that our voice prosthesis had the lowest resistance.
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