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Biomedical subjects

L Tomov

Publications and source records attributed to L Tomov.

At least 19 recordsLinked to original sources
PubMed1978

[Clinical trial of the preparation clofazolin used intravenously].

The authors studied the hypotensive effect of the Bulgarian preparation Chlophazolin in ampoules of 0,15 mg, administered i. v. The study covered 50 patients, 44 of them with hypertonic disease II and III stage and the rest (6)--with renal and renovasal hypertension. The i. v. administration of chlophazolin was established to have a marked hypotensive effect and be expedient for the treatment of hypertonic crises and hypertension with high values. In a dose of 0,15 mg i. v. the preparation leads to a sharp decrease in the first 20 min, whereas during the following hours it is kept to lower values: systolic pressure-an average decrease of 30-40 mm Hb in a lying position, to 45-50 mm Hg in an erect position; the diastolic pressure-an average decrease of 10-15 mm Hg in a lying position to 20-25 mm Hg in an erect position. The hypotensive effect is better manifested in higher initial values of the pressure. It lasts approximately more than 13 hours but in 1/5 of the patients, with higher values of blood pressure, its effect is exhausted within 6-8 hours. Side effects of the preparation were registered in 26 per cent of the cases; orthostatic disturbances, sleepiness, dryness of the mouth, nausea. I. v. administration of chlopazolin does not change the excretion of urea and creatinine, diuresis and serum levels of sodium, potassium and chlorine.

Adolescent↗
PubMed1977

[Cardiac output, blood gas analysis and the acid-base state of the blood in chronic cor pulmonale].

In 61 patients with chronic cor pulmonale with compensation and decompensation of circulation, the stroke and minute heart volume were studied as well as the indices, characterizing the blood-gas contents and acid-base blood state. The minute heart volume in the patients examined proved to be with normal values. Stroke heart volume is decreased in all patients examined with chronic cor pulmonale. The acceleration of heart activity enables the maintenance of normal minute volume. Hypoxemia has a cardiac depressive effect as regards minute volume and heart rate. The moderate hypercapnia has a certain stimulating effect on heart. A direct proportional correlation exists between the hypercapnia degree and the tendency of minute volume increase and especially of heart rate. The campaign against hypoxemia is an essential element in the prophylaxis and early treatment of chronic cor pulmonale.

Acid-Base Equilibrium↗
PubMed1976

[Changes in hemodynamics in acute myocardial infarct following administration of potassium orotate].

The basic hemodynamic indices prior to and post the treatment with potassium orothate were investigated 25 patients with acute myocardial infarction. The method for quantitative investigation of hemodynamics is used by the dilution of colour indicator and recording of the dilution curves with the ear oximeter. The results obtained are compared with those of a control group of 30 patients with the same disease. The data revealed that in the treatment with potassium orothate a more favourable evolution develops in the values of cardiac output, total peripheral vascular resistance and the volume of the circulating blood. The authors associate the more favourable effect of these indices with a faster recovering of the contractibility of the myocardium.

Acute Disease↗