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L Tomatis

Publications and source records attributed to L Tomatis.

At least 163 records · Page 9Linked to original sources
PubMedDate not supplied

Ito cell tumor: immunohistochemical investigations of a rare lesion in the liver of mice.

In 2 lifespan transgeneration experiments using a total of 4,682 CBA/J mice, we observed uncommon lipomatous lesions in the livers of 8 mice independent of the treatment. Macroscopically, the lesions were described as pale white areas (2) or nodules (6) during necropsy. The lesions ranged from 1 to 15 mm in diameter. Microscopically, the lesions consisted of nodular aggregations of round to spindle-shaped cells that partly caused distinct compression of the adjacent hepatic parenchyma. The tumor cells were smaller than hepatocytes and had dark oval nuclei. Many of the more spherical cells contained clear vacuoles of various sizes, which were shown to be lipid droplets by oil red O staining. In addition to Gomori's silver and Masson's trichrome staining, several immunohistochemical stains were used to characterize the origin of the proliferating cells. Tumor cells were labeled by vimentin, actin, desmin, and proliferating cell nuclear antigen. The 2 cell phenotypes showed similar staining characteristics. Increased amounts of laminin and tenascin, 2 extracellular matrix proteins of the liver, were detected within these neoplasms. Summarizing, we suggest that these tumors are of Ito cell origin.

Adenocarcinoma↗
PubMedDate not supplied

[Commitment and ambiguous complexity in scientific research].

The manicheistic temptation of concluding that the good, but also the best science, is the science made by scientists morally and ideologically committed to alleviate both physical illness and health and social inequalities, would take us far away from the painful complexity of the mixture of good and bad, right and wrong, bright and obscure, and from the ambiguities and ambivalent situations that may originate from it, in which not only scientific research but our entire existence is soaked. The scientist should see very clearly his obligations toward society and his fellow humans in order to resist the ambiguous complexity where the interest for a scientific result can be exploited for ignoble purposes or, as Robert N. Proctor reminds us in his recent book "The Nazi War on Cancer", where "the routine practice of science can so easily coexist with the routine exercise of cruelty." Research committed to prevention and to the struggle for health and social equity was for quite a while successfully hampered by closing the financial channels and depriving it of the necessary means. The block by lack of funds has been replaced in recent times by a block by plenty through the attraction exerted on many scientists by availability of conspicuous and sure funds for research on themes chosen by the economic power.

Humans↗
PubMedDate not supplied

Poverty and cancer.

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Health Services Accessibility↗