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Biomedical subjects

L Thuesen

Publications and source records attributed to L Thuesen.

69 records · Page 4Linked to original sources
PubMed1986

One-year experience with a low-fat, low-cholesterol diet in patients with coronary heart disease.

For 3 mo, 14 patients with severe coronary heart disease and serum cholesterol levels of 6-9.5 mmol/l were treated with a diet containing 10% of total energy from fat and less than 100 mg cholesterol per day. Serum cholesterol and serum low-density lipoprotein (LDL) cholesterol were reduced by 33% and 41%, respectively, while serum high-density lipoprotein (HDL) cholesterol and serum triglycerides did not change significantly. After 3 mo, patients were asked to maintain a diet as low in fat as possible for long-term treatment. After 12 mo, a 4-day diet recall showed a mean fat intake of 21.4% (range 7.3-37.8%). On average, serum cholesterol and serum-LDL cholesterol were reduced by 14% and 18%, respectively, from pretreatment values. Serum triglycerides decreased by 27% and serum-HDL cholesterol increased by 18%. At month 12 serum cholesterol and changes in serum cholesterol were correlated to the consumption of fat.

Adult↗
PubMed1986

Exercise capacity and cardiac function in type 1 diabetic patients treated with continuous subcutaneous insulin infusion. A controlled study.

In order to investigate the effect of improved glycaemic control on exercise capacity and cardiac function, bicycle exercise and echocardiography at rest and after exercise was performed in 24 short-term type 1 diabetic patients, randomized to conventional insulin therapy (CIT) or to continuous subcutaneous insulin infusion (CSII). After 6 months significant improvement in glycaemic control was seen in the CSII group showing a decrease in mean blood glucose and haemoglobin A1c (HbA1c), while no change was observed in the CIT group. Exercise capacity increased by 24% (p less than 0.01) in the CSII group and decreased by 16% (NS) in the CIT group. In the CSII group fractional shortening of the left ventricle during rest decreased by 14% (p less than 0.02), while an increase of 2% (NS) was seen in the CIT group. Further, changes of left ventricular fractional shortening during rest were inversely correlated to changes in exercise capacity. After exercise, fractional shortening of the left ventricle and rate-pressure product was unchanged in the two groups. In conclusion this study shows a beneficial effect of improved glycaemic control induced by CSII on exercise capacity possibly by reducing resting state demands to the cardiovascular system.

Adult↗
PubMed1985

Increased myocardial contractility in short-term type 1 diabetic patients: an echocardiographic study.

Cardiac function was investigated by echocardiography in 24 short-term Type 1 diabetic patients with a mean diabetes duration of 7 years (range 4-14 years) during conditions of ordinary metabolic control. Compared to 24 age and sex matched normal control subjects, measurements of myocardial contractility as left ventricular fractional shortening and mean circumferential shortening velocity were increased by 12% and 20% respectively. Another 8 Type 1 diabetic patients were examined during conditions of poor (hyperglycaemia and ketosis) and good metabolic control. Following improved glycaemic control, left ventricular fractional shortening and mean circumferential shortening velocity decreased by 16% and 24% respectively. Our findings show that short-term Type 1 diabetes is associated with increased myocardial contractility. Furthermore, this condition is related to the state of metabolic control.

Adult↗
PubMed1984

Beneficial effect of a low-fat low-calorie diet on myocardial energy metabolism in patients with angina pectoris.

8 patients with exertional angina pectoris were treated for 3 months with a low-fat, low-calorie diet. Serum cholesterol was reduced by 28% and body-weight by 7.9 kg on average. The effect of the dietary intervention was assessed by a heart metabolic study during pacing-induced tachycardia. After dietary treatment coronary sinus blood-flow and myocardial oxygen consumption were considerably reduced, but pacing time before angina developed increased. Other improvements were a reduction in lactate release during pacing, a reduction in citrate release during recovery, a reduction in alanine output during rest and recovery, and a lower uptake of glutamate. The results suggest a beneficial effect of low-fat, low-calorie dietary treatment on myocardial energy metabolism in patients with exertional angina pectoris.

Alanine↗
PubMed1984

Myocardial glutamate and alanine exchanges related to carbohydrate metabolism in patients with normal and stenotic coronary arteries.

Myocardial exchanges of glutamate, alanine, glucose, lactate, free fatty acids (FFA) and oxygen in resting state were determined in nine subjects (controls) without and in 28 patients with coronary artery disease (CAD). Patients with CAD showed increased myocardial glutamate uptake (2.51 +/- 0.60 mumol/min) and alanine release (1.25 +/- 0.60 mumol/min) compared to controls (glutamate uptake: 1.66 +/- 0.79 mumol/min; alanine release: 0.63 +/- 0.41 mumol/min). Myocardial glucose and lactate uptake was augmented in CAD patients, whereas FFA arteriovenous differences were decreased in patients with three-vessel-disease. The amount of glutamate taken up by the heart correlated positively to lactate uptake in all subjects (r = 0.84) and to external glucose utilization in patients with CAD (r = 0.72). Myocardial alanine release was positively related to glucose and lactate uptake in controls and in patients with only moderate CAD (one-vessel-disease). Glucose and FFA uptake correlated inversely in controls (r = 0.84), but not in CAD patients. A tight relation between exchanges of glutamate/alanine and carbohydrate metabolism in human heart is demonstrated. The data suggest altered myocardial substrate exchange towards augmented carbohydrate utilization in CAD patients in resting state. The results agree with in vitro and animal studies suggesting extraction of glutamate from the circulation to be of importance for maintaining carbohydrate consumption in chronic ischaemic heart disease.

Adult↗