Notes of a biology-watcher. The world's biggest membrane.
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Biomedical subjects
Publications and source records attributed to L Thomas.
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Occlusion of cerebral capillaries due to acute swelling of the endothelial cells has been demonstrated in the brains of turkeys with encephalopathy caused by Mycoplasma gallisepticum (S-6 strain) infection. Similar capillary lesions were seen in rats with rolling disease, caused by M. neurolyticum toxin. Such lesions may be the basis of ischemic necrosis of the brain.
The fatal encephalopathy associated with M. gallisepticum strain S6 in turkey poults was completely curable by treatment with tylosin or pleuromutilin. The lesions of cerebral polyarteritis disappeared after therapy. Polyarthritis developed in some birds after recovery from encephalitis. Immunofluorescent studies revealed that intravenously injected organisms became localized as microcolonies within the walls of cerebral and periarticular arteries, and in the glomeruli. Turkey IgG deposition was demonstrated on the glomerular basement membranes, but not in the arterial lesions. The results suggest that the pathologic changes caused by this microorganism are due to selective localization and growth in arteries.
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