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Biomedical subjects

L Thienpont

Publications and source records attributed to L Thienpont.

31 records · Page 2Linked to original sources
PubMed1986

Venous air embolism following insufflation of the urethra.

Venous air embolism following urethral inflation only scarcely documented: an extensive search of the literature yielded four papers relating to this subject. We report a new case of venous air embolism due to this uncommon etiology. Careful study revealed some common pathogenetic features with previously reported cases. Some important precautions can diminish the likelihood of gas embolism and reduce its fatal outcome in situations, similar to the kind mentioned.

Aged↗
PubMed1976

Fetal Chiari's type III malformation.

The morphological findings in a 4- to 5-month-old female fetus with Chiari's type III malformation are described. This observation strongly supports the view that a defective closure of the roof plate is the primary cause of this malformation, and relates it to the Arnold-Chiari and Dandy-Walker syndromes.

Arnold-Chiari Malformation↗
PubMed1975

[Influence of thioacetamide on nucleolar apparatus of the liver. Cytophotometric study].

The nucleolus associated chromatin in Feulgen-stained liver cells of TAA treated rats is studied using the Lison cytophotometer. The results indicate that the increase in nucleolar volume in these hepatocytes is accompanied by an increase in Feulgen-DNA contents of the nucleolar apparatus, both in rats treated with a normal standard diet and with a Miller and Price diet. This increase is maximal 2 days after a single dose of 10 mg/100 g body weight and reaches 50 and 25% respectively. These results are discussed with consideration to mitosis, distributional error and the metabolic DNA hypothesis.

Acetamides↗
PubMedDate not supplied

Identification of alpha-phenylethylamine in judicial samples.

alpha-Phenylethylamine was recently identified in samples from several judicial cases using chromatographic (high-performance liquid chromatography-diode-array detection, gas chromatography-mass spectrometry, and gas chromatography-Fourier transform infrared detection) and spectrometric (nuclear magnetic resonance) techniques. In the first case, 1 kg of a white powder was found in a basement laboratory. It contained caffeine and more than 15% alpha-phenylethylamine. In the second case, two white powders were seized from a female. One powder consisted of pure amphetamine, and the other was a mixture of caffeine, amphetamine, and alpha-phenylethylamine. Four months later, a couple, who were known drug users, were found dead in their apartment. Urine samples of both victims contained large amounts of amphetamine together with alpha-phenylethylamine. Recently, 0.13 kg of a white powder and 0.30 kg of an orange powder were seized during a law enforcement operation. Both powders were mixtures of caffeine, amphetamine, and alpha-phenylethylamine. The data presented demonstrate the recent and unrelated repetitive occurrence of alpha-phenylethylamine in the circuit of illicit drugs.

Chromatography, High Pressure Liquid↗
PubMedDate not supplied

Quantitative determination of amphetamine and alpha-phenylethylamine enantiomers in judicial samples using capillary gas chromatography.

alpha-Phenylethylamine was recently reported by us in various samples seized from the illicit drug circuit. At first, alpha-phenylethylamine was identified in powders that generally contained amphetamine and caffeine. Then, a couple, who were known drug users, was found dead in their apartment. Urine samples from both victims contained large amounts of amphetamine and alpha-phenylethylamine. All of the positive samples were re-examined with gas chromatography to determine the chirality of the detected drug or drugs. The homochiral derivatizing reagent N-trifluoroacetyl-L-prolyl chloride was used to convert the drug enantiomers into their corresponding diastereomeric derivatives. These derivatives were separated on an achiral stationary phase and detected using either flame ionization detection (FID) or on-line Fourier-transform infrared spectrometry (FTIR) for quantitative or qualitative purposes, respectively. Excellent separation was realized between all diastereomeric derivatives, and interference of excess, nonvolatile derivatizing reagent was reduced to a minimum. All powder samples consisted of racemic mixtures for alpha-phenylethylamine and for amphetamine. The urine samples also contained both enantiomers of alpha-phenyl ethylamine and amphetamine, albeit in varying proportions. These findings again substantiate the synthetic origin of alpha-phenylethylamine, attributing its presence in the urine of both victims to intentional or accidental intake. The disproportionate isomeric composition found in the urine samples confirms previous reports of a stereoselective metabolism for amphetamine enantiomers and suggests a similar pharmacokinetic profile for alpha-phenylethylamine.

Amphetamine↗
PubMedDate not supplied

Tissue distribution of amphetamine isomers in a fatal overdose.

A young man (22 years old) died of a cardiorespiratory arrest a few hours following admission to the emergency department of a hospital. He was found lying seriously ill in the parking lot of a dance club. Screening of postmortem blood and urine with enzyme multiplied immunoassay (EMIT) detected only amphetamines, caffeine, and cotinine. Further screening of blood, urine, and stomach contents with thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC) was negative for all three matrices. Specific conditions for amphetamines were used for the gas chromatographic (GC) screening (GC-mass spectrometric [MS] and GC-nitrogen-phosphorus detection). This resulted in the preliminary identification of amphetamine in both blood and urine. Confirmation of the presence of amphetamine in all available postmortem specimens was provided by mass and infrared spectral data (GC-MS and GC-Fourier transform infrared spectrometry) after derivatization. Quantitative results and differentiation between the enantiomers of amphetamine were obtained after chiral derivatization. The calculated concentrations disclosed amphetamine ingestion as the cause of this fatality.

Adult↗
PubMedDate not supplied

Prolactin and colorectal cancer: is there a connection?

UNLABELLED: The purpose of this study was to confirm the reported incidence of hyperprolactinemia in colorectal cancer and to find further evidence for an ectopic prolactin production by the tumor. MATERIAL AND METHOD: Thirty two consecutive patients with an adenocarcinoma of the colon (n = 17) or the rectum (n = 15) were included. Preoperative serum prolactin concentrations were determined and correlated with CEA concentrations and tumor stages. To exclude an ectopic production by the colon cancer, prolactin concentrations were determined during the operation, in the peripheral blood and in the efferent venous drainage area of the tumor. After resection, immunohistochemical staining for prolactin was made in all resected tumors. RESULTS: In all except two patients with a rectal cancer, preoperative plasma prolactin concentrations were normal. Peroperative serum concentrations of prolactin were high in all patients. No significant gradient was found between the peripheral venous concentration and the local venous concentration in the drainage area of the tumor. Immunohistochemical staining for prolactin was positive in only one rectal cancer. Finally, no correlation was found between plasma prolactin concentrations and tumor stages or CEA concentrations. CONCLUSION: Our results do not support the hypothesis of an ectopic prolactin production by colon adenocarcinoma. Only in a subgroup of rectal cancers, an ectopic prolactin production remains probable. At present, prolactin cannot be recommended as a tumor marker in colorectal cancer.

Adenocarcinoma↗