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Biomedical subjects

L Teppo

Publications and source records attributed to L Teppo.

At least 127 records · Page 7Linked to original sources
PubMed1979

Second primary cancers in patients with carcinoma of the lip.

The occurrence of second primary cancers in patients with lip cancer was evaluated in order to test certain etiologic hypotheses. All cases of lip cancer reported to the Finnish Cancer Registry in 1953-74 (3303 men, 320 women) were followed up for a second (or third) primary cancer through the files of the Registry either to death or to 31 December 1974 (a total of 25 510 person-years). The expected numbers of cases were calculated on the basis of the incidence rates specific for sex, age, time and residence (urban or rural) in Finland. A higher than expected risk of cancer was found among both urban and rural male lip cancer patients; among women the observed number of new primary cancers did not differ from that expected. A significant excess risk among males was noted for cancers of the lung and larynx (rural patients) and for non-melanomatous skin cancer in locations other than the head and neck (urban patients). The association of cancers of the lip, lung and larynx found earlier on a geographic level supports the hypothesis that tobacco smoking is a common risk factor in these cancers. The differences in the relative risks between urban and rural patients, however, suggest that the risk factors in lip cancer in urban areas might be partially different from those prevalent in the rural population. The results do not support the hypothesis that sunlight is an important risk factor in lip cancer.

Adult↗
PubMed1979

Epidemiology of colon cancer in Scandinavia.

The occurrence of colon cancer in four Scandinavian (Nordic) countries--Finland, Denmark, Norway and Sweden--is described. In addition, a number of correlations relevant to the etiology of colon cancer are presented. The observable differences in the risk for colon cancer among the Nordic countries can largely be accounted for by socioeconomic factors.

Adult↗
PubMed1978

Epidemiological evaluation of sunlight as a risk factor of lip cancer.

A total of 3,169 cases of lip cancer in males and 303 cases in females were diagnosed in Finland and reported to the Finnish Cancer Registry in 1953-73. The diagnosis was verified histologically in 95% of the cases in males and in 92% in females. The mean annual age-adjusted incidence rate was 7·3/10(5) in males and 0·5/10(5) in females. The annual incidence for males has decreased since the early 1960s. The decrease involved all age groups and was not due to a cohort effect. Only a very slight decrease in the risk was observable in females. The incidence was clearly higher in rural than in urban areas, the urban/rural ratio of the age-adjusted incidence rates being 0·6 for males. A decrease in the risk with time was observable for both urban and rural populations. The risk was highest in the northern and eastern parts of the country, for both urban and rural areas. It was concluded that the decrease in the incidence of lip cancer in Finland cannot be accounted for solely by the process of urbanization. An inverse relationship was found between the mean annual amount of solar radiation and the risk of lip cancer. The results are not in accordance with the theory of the association between exposure to actinic radiation and the risk of lip cancer. The synergistic action of some other factors related to outdoor occupation, and probably smoking, would provide a better explanation for the observations in this study.

Adult↗
PubMed1978

Cancer of the eye, a review of trends and differentials.

An analysis was made of the incidence and mortality of cancer of the eye in different countries. In general, cancer of the eye was more common in males than in females. The differences in both incidence and mortality rates between countries were great, the white populations in Scandinavia exhibiting the highest rates. The rates were rather constant over time, and only a few increasing or decreasing trends were observable. Tumours in children 0-14 years of age and those in adults were also epidemiologically distinct entities, which suggests differences in etiology. Both incidence and mortality rates in adults were positively correlated to the latitude of the country or area, and a positive correlation was also found between the incidence or mortality rate for cancer of the eye in adults and those for cutaneous melanoma.

Age Factors↗
PubMed1977

Malignant mesothelioma of 17 years' duration with high pleural fluid concentration of hyaluronate.

A patient suffering from malignant mesothelioma of funicular (intra-abdominal) origin is described. The disease proved fatal after 17 years' duration, which is the longest ever described without treatment. The analysis of the pleural fluid hyaluronate concentration gave strong evidence of the malignant aetiology, while biopsies taken 17 and 8 years before the pleurisy caused marked difficulties as to interpretation. In malignant mesothelioma a markedly elevated pleural fluid hyaluronate concentration appears to be a characteristic and specific feature.

Abdominal Neoplasms↗
PubMed1977

Causes of death among female patients with cancer of the breast and intestines.

The cause-specific mortality of women with cancer of the breast or of the intestines (= small intestine and colon) diagnosed in 1953-70 in Finland was analyzed with respect to the extent of the disease, the age of the patient at the time of diagnosis, and the follow-up time. The total mortality in breast-cancer patients was higher than had been expected during the entire follow-up period (maximum of 18 years), whereas in patients with intestinal cancer no more than slight excess mortality existed after 5 years of follow-up. The mortality from cardiovascular diseases was less than had been expected among patients with intestinal cancer. Patients with non-localized cancer of the breast had a risk of dying from accidents and other violent causes of death during the first 5 years of follow-up which was slightly higher than expected. From information compiled from various sources, the Finnish Cancer Registry records not only the official cause of death mentioned on the death certificate, but also a "corrected" cause of death. With this correction, the mortality from forms of malignancy other than the primary cancer was lower than had been expected during the first 5 years of follow-up, and subsequently reached the level expected. In regard to specific sites, mortality lower than that expected was observed for cancer of the stomach (both breast- and intestinal-cancer patients), and cancer of the cervix uteri (breast-cancer patients). In patients with localized breast cancer, the mortality from leukaemia was higher than that expected after 5 years of follow-up. No mutual excess risk was demonstrable with breast and intestinal cancers.

Adult↗
PubMed1976

Breast cancer and use of rauwolfia and other antihypertensive agents in hypertensive patients: a nationwide case-control study in Finland.

Two nationwide registers, the Finnish Cancer Registry and a register of persons entitled to free drugs for hypertension, were linked in a case-control study of the association of breast cancer and use of rauwolfia. Cases were all hypertensive patients in whom breast cancer was diagnosed in 1973. To test the association specifically with rauwolfia, controls were hypertensive women matched with the cases for age and geographic area and approximately matched for duration of treatment for hypertension. There were 109 case-control pairs. Use of any physician-prescribed drugs during the year prior to diagnosis of breast cancer was ascertained from original prescriptions. In the first set of analyses the patients were classified according to the drug used during most days of the year ("main antihypertensive agent"). In the second set a person qualified as a user of the respective drug regardless of the amount taken. The relative risks in the use of rauwolfia, methyldopa, another synthetic antihypertensive or a diuretic as main antihypertensive agent all ranged between 0.90 and 1.11. The results based on use of a drug in any amount were similar. Next, pairs in which duration of treatment for hypertension was different for cases and controls were excluded. The relative risk associated with use of rauwolfia as main antihypertensive agent then increased from 1.00 to 1.30 and the risk associated with use of any amount of rauwolfia from 1.16 to 2.14. Simultaneously, the relative risk in the use of digitalis was raised from 1.33 to 2.67 and of nitroglycerin from 1.00 to 1.71. Cases also used more types of antihypertensive agents simultaneously than controls. There was no association between rauwolfia-use and breast cancer in analyses limited to pairs in which neither case nor control used digitalis. Thus, there was not a consistent drug-specific association between rauwolfia-use and breast cancer in hypertensive patients. An underlying association of hypertension, heart disease or its treatment (digitalis) and breast cancer may have confounded some of the results of this and earlier studies. In conclusion, it is unlikely that use of rauwolfia increases the risk of breast cancer.

Adult↗
PubMed1976

The increase in working years due to elimination of cancer as a cause of death.

The relative significance of various forms of cancer in terms of causing death is analysed by estimation of the increase in person-years of working age (20-64 years) following elimination of the disease. Methods based upon the theory of competing risks are applied to the statistics on causes of death in Finland during the years 1966-70. It is estimated that if there were no lung cancer (the commonest type of cancer in both morbidity and mortality statistics in males in Finland) the annual deaths saved would yield 5,900 working years (both sexes combined). Leukaemia and cancer of the stomach would be next in rank order, with figures of respectively 4,000 and 3,900 working years more. Female cancer with the highest incidence, that of the breast, would be characterized by 2,900 additional working years. The significance of types of cancer that affect young people is stressed in these calculations: leukaemia, brain tumours and lymphomas (both sexes combined) are 6th, 12th and 11th respectively in the statistics of cancer causes of death, but 2nd, 4th and 6th respectively in the list of additional working years to be gained by elimination of the disease. On the other hand, cancer of the prostate, 3rd in males according to the annual numbers of cancer deaths, would take the 15th position for the increase in working years in males. If no risk of cancer existed, the annual deaths saved would produce 36,000 working years, a figure exceeded only by those for cardiovascular diseases (55,000 working years) and accidents (51,000 working years). The results indicate that no practical differences exist between the results derived under the assumptions of various models for competing risks, but that the exclusion of competing risks may result in considerable degrees of bias in estimation if the population has a high general mortality.

Adolescent↗
PubMed1976

Cancer in the offspring of fathers in hydrocarbon-related occupations.

A case-control study has been conducted to see whether a hydrocarbon-related occupation of the father at the time of conception constitutes a risk factor for malignant disease in the offspring. The series comprised 852 cancer cases from the Finnish Cancer Registry and 852 controls matched for date of birth and domicile. The father's occupation for both the cases and controls was ascertained from the records of antenatal clinics. No significant associations were found between the commonest types of childhood cancer and hydrocarbon-related occupations--that is, motor-vehicle mechanics, machinists, miners, painters, and motor-vehicle drivers. Risk ratio 2 was excluded from most of the 95% confidence intervals for children under 15 years of age. The results do not support the hypothesis that there is an excess risk of cancer in the children of fathers in hydrocarbon-related occupations.

Adolescent↗
PubMed1976

Chordoma in Finland.

During the period 1953-1971, 20 cases of chordoma were reported to the Finnish Cancer Registry. Twelve of the patients were males. The mean annual (crude) incidence of chordoma in Finland was 0.30/10(6) in males, and 0.18/10(6) in females. Fifteen of the tumours were sacral, three vertebral, and two cranial. Local recurrences were common, and distant metastases were observed in 60 per cent of the cases; this exceeds the proportion usually mentioned in the literature. The commonest treatment was surgery combined with postoperative high-dose irradiation. The relative 5-year survival rate was 35 per cent, and the 10-year rate 18 per cent.

Adolescent↗
PubMed1976

Acute coeliac artery occlusion: initial collateral blood flow from the superior mesenteric artery. An experimental study.

The collateral blood flow from the superior mesenteric artery after acute occlusion of the coeliac truck was measured in experiments in dogs. Immediately after clamping of the coeliac axis the collateral flow was about 30 % of the original coeliac blood flow. During an observation time of three hours the collateral flow increased, the corresponding value at the end of experiment being about 50 %. At the same time the blood pressure in the coeliac artery rose from a mean value of 20 mmHg to 35 mmHg. The initial collateral blood flow was evidently not sufficient, since after this short occlusion period ischaemic changes, even necrosis, were observed in the liver and stomach in some of the test animals.

Acute Disease↗
PubMed1975

Incidence, mortality or prevalence as indicators of the cancer problem.

The magnitude of the cancer problem, as conveyed by the incidence, mortality and prevalence figures, was studied by analysis of the material of the Finnish Cancer Registry from 1953-1970. The prevalence was defined as the number of persons who had cancer, or had ever had cancer, and were living on December 31, 1970. The incidence and mortality of cancer in males exceeded those in respect of females, whereas the prevalence with females was clearly higher than that with males. According to all 3 indices, the commonest site of cancer was in the lungs in males. In females, cancer of the breast was the commonest malignant neoplasm measured by incidence and prevalence, where as in mortality statistics it was second to cancer of the stomach. Cancers with poor prognosis such as cancer of the lung, stomach, pancreas and esophagus, and leukemia, exhibited relatively low prevalence figures, whereas cancers with good prognosis, such as cancer of the breast, uterus, larynx and lip, showed relatively large numbers of prevalent cases. In females, cancer of the genitals, including the breasts, constituted nearly as may prevalent cases as did the total figure in males. As the 3 cancer indices measure different things, the nature of the index used should be taken into account in evaluation of the magnitude of the cancer problem.

Adolescent↗