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Biomedical subjects

L Teot

Publications and source records attributed to L Teot.

36 records · Page 2Linked to original sources

Ultrasonography of the normal and abnormal antenatal development of the upper limb.

The degree of severity of congenital deformities of the hand, as well as any coexisting congenital anomaly should be evaluated especially if there is a possibility of therapeutic termination of pregnancy. This may be relatively easy in the case of some major malformations which affect the neurological or intellectual capacity of the child. It is however more difficult in the presence of predominantly motor anomalies, and with distally based anomalies of the upper limb which may be amenable to later reconstructive surgery.

Arm↗

Pedicle scapular apophysis transplantation in congenital limb malformations.

Congenital segmental amputations are difficult to correct. Free interposition bone grafts with growth centers were tried experimentally by many investigators even at the beginning of this century. Attempts at clinical application of this principle, however, were mostly failures. More recently, with the advent of microsurgical techniques, new hope has arisen. In particular, toe transfers in children have confirmed the survival of such growth centers, as these transfers could be found to grow normally [1]. The transfer of vascularized epiphysis with its growth plate has been shown in animal limbs to achieve a rate of growth comparable with the normal site. Originally, two donor sites were used with acceptable results in children. These were the superior epiphysis of the fibula and the iliac crest. So far, in most clinical applications, they have been used as appositional transfers. However, a growth problem occurring at the donor site has proved to be quite crippling.

Amniotic Band Syndrome↗

[Hazards of ultrasonography of the hip].

We studied the value of ultrasound examination combined with conventional clinical evaluation in screening for congenital defects of the hip in a study including more than 3,000 neonates. We used two kinds of ultrasound methods, i.e. the morphological method, that is highly standardized and seeks to identify several well-defined anatomic landmarks (Graf's technique), and the dynamic method, that uses transverse flexion, frontal flexion or medial sections to determine the degree of stability of the hip. We describe these sections in detail so that pediatricians may correctly appreciate the images obtained. The respective indications of each section depend on the findings made as the investigation advances. Rigorous adherence to precise rules is now possible and is the only means for ensuring that these techniques will be used rationally in a way that can be expected to significantly reduce the still considerable number of dislocations and dysplasias of the hip discovered beyond three months of age.

Evaluation Studies as Topic↗

[Ultrasonic and anatomical correlation of the normal hip in the newborn infant].

Ultrasound studies were made on the cadavers of seven normal new-born foetuses. The sonographic images obtained were compared with anatomical sections made in corresponding planes. An accurate analysis of the anatomy of the cartilaginous acetabular roof and labrum in these hips confirmed the accuracy of ultrasonography. Ultrasonography has made it possible to resolve certain doubts about the radiographic examination of infants between birth and the third month.

Fetus↗

Pedicled scapular apophysis transplantation. Growing grafts studied in dogs.

Twenty-eight immature dogs, divided into three groups, have been studied to determine the possibilities of pedicled epiphyseal transplantation from a rarely used donor site area, the scapula. One group of 8 immature dogs were studied anatomically using India ink and Batson's compound injection methods. We identified the vascular pattern of the diaphyseal portion of the graft, consisting of the lateral crest or border of the scapula. In two groups of 10 immature dogs, this area was used as a pedicled island graft to rebuild the semiresected or totally resected proximal humerus. There were marked differences between these two groups on the basis of morphologic, histologic, histochemical and electron microscopic aspects of the samples. Preservation of normal growth appeared to be directly related to the compressive forces applied to the graft. Preservation of the cartilage was also related to the biomechanical situation; fibrocartilage and signs of arthrosis were noted 1 year after the operation in several animals whose humeri had been fully subjected to normal stresses. Both the diaphyseal and epiphyseal areas had increased one- to fivefold in volume, but longitudinal growth was markedly deficient.

Animals↗

Ultrastructural aspects of nerves, bones, and vessels in hereditary sensory neuropathy.

This study concerns two children, from the same otherwise normal family, presenting progressive spontaneous amputations of the limbs, suggesting peripheral hereditary sensory neuropathy. Samples from the distal nerves and vessels and the distal tibial epiphyses were examined ultrastructurally. The nerves showed signs of degeneration, and a typical bone necrosis, without osteoclasts, was observed in the 2 cm margin of the samples. Simultaneous modifications of the vessels suggest a neurally initiated vascular reflex resulting in bone destruction. Theories that might explain the observations are discussed.

Arterioles↗

[Biology of micro-vascularized cartilaginous transplantation in the growing dog].

Epiphyseal bone transplantations including growth area have been extensively studied experimentally in different animals and applied in children for several decades. Results were unpredictable and the amount of growth obtained with the graft could get 50 per cent of the normal. Development of microsurgical techniques has determined new possibilities of epiphyseal transfer with the respect of the epiphyseal vascularization. Growth plate germinal cell division is directly related to the epiphyseal vascular respect. In a large multifacetted program we could successively determine the vascular patterns of the donor site areas and then utilized different grafts in some experimental situations reproducing the clinical pathology in children, like hip dysplasia or epiphyseal defects after resection for tumor or infection. Results demonstrate that the main problem, in epiphyseal transplantation, is not vascular but mechanical. Further studies have to be done in this direction.

Aging↗

[Arrangement of collagen fibers in the epiphyses and metaphyses of long bones in vertebrates].

The arrangement of collagene fibers in bone epiphyses and mataphyses form various species of reptiles and mammals was studied with a polarized light microscope and with a scanning electron microscope. In spite of the variety of shape observed in the long bone extremities of different species, the collagenic fibers arrangement in the bone epiphyses and metaphyses appeared constant. Even in reptiles known to lack a growth plate, the metaphyseal and epiphyseal fiber patterns evoked those observed in mammals. A common fiber pattern may therefore be proposed which allows the coexistence of two apparently incompatible functions: growth, that induces an increased fragility at the epiphyseo-metaphyseal junction as opposed to mechanical support, which has to cope with load and traction forces at the same junctional site.

Alligators and Crocodiles↗

[Fatal Marfan syndrome in the neonatal period].

Case-report of neonatal Marfan Syndrome with at birth the following observations: arachnodactyly, excessive length of arm, cardiac anomalies with hemodynamic troubles leading to death within 4 days. Anatomical data of the postmortem examination and histologic anomalies of the aorta confirm the diagnosis. No case of Marfan syndrome are to be found among forebearers. These characteristics underline the rarity, the gravity of the pronostic and the often sporadic appearance of the Marfan syndrome when revelated in the neonatal period.

Abnormalities, Multiple↗

Epiphyseal vascularization during growth: the upper limb.

Sixty fetal, newborn and child cadavers were injected with India ink and plastic material (Batson's technique) via the subclavian artery. The arterial and capillary intracartilaginous and intraosseous networks of the physes of the long bones of the upper limb were then studied by microdissection of the vascular sources and serial epiphyseal sections in different planes. Already present in the third week of fetal life and present all during the rest of life, this circulation plays a fundamental role not only in the ossification of the epiphyseal cartilage but also in the trophicity of the bone that supports the cartilaginous articular surfaces. Like those of the lower limb, the epiphyses of the upper limb present a typical vascular pattern consisting of three entries, with the exception however of the inferior extremity of the ulna.

Arm↗

[Acetabuloplasty using pedicle graft of the iliac crest epiphysis in puppies].

Pedicled iliac crest epiphysis transplantation was performed after resection of the outer portion of the acetabulum in 30 puppies 3 months old. The best joint congruency was obtained when using a vertical pedicled graft, the surface of which developed into normal articular cartilage through metaplasia, and presented normal cartilage growth by means of conservation of the epiphyseal vessels. The results of this experiment enable the authors to propose a new surgical technique in the treatment of certain difficult dysplastic conditions in the hip.

Acetabulum↗

Pseudoaneurysms of the radial artery. Importance of microsurgery. Apropos of a case.

Following a case of pseudoaneurysm of the radial artery, curiously a rare pathological entity, the authors reviewed the literature, which consists of a maximum of 50 publicized cases. The arteriographic, plethysmographic and clinical studies as well as the anatomic and physiologic findings, all seem in favor of a treatment consisting of restoration of the vascular permeability of the principal arterial axes of the forearm (radial and ulnar arterial axes). Conservative treatment may expose the affected limb to a latent or immediate functional impotency, which may be more or less serious. The authors propose a microsurgical technique, with venous interposition grafting, for a better short or long term result, and also to replace the loss of substance secondary to the resected pseudoaneurysm.

Adult↗

The free scapular flap.

The scapular flap is described, based on the posterior cutaneous branch of the inferior scapular artery. This flap has been successfully used in four clinical cases. The advantages of this flap lie mostly in its large, long, and very dependable vascular pedicle. It can be taken with the patient on his side or prone. The skin is thin and does not need defatting. The main disadvantage is the scar, which is on the posterior aspect of the scapula. This flap is very useful in the treatment of small defects of the ankle or lower leg.

Amputation, Surgical↗

[Acetabuloplasty by pedicled transfer of the iliac crest apophysis in the dog].

Appositional incremental acetabuloplasty using a self growing iliac crest graft pedicle on its epipyseal vessels was performed in 54 puppies 3 months old. Remodeling an adaptation to the shape of the acetabulum is excellent in most of the cases, issuing into a spherical composite cavity. Persistance of a hyaline cartilage is noted until the end of the first years, but long term morphological transmission electronmicroscopy studies demonstrate a progressive transformation into fibrocartilage. This experimental study demonstrates the possibility to use remodeling and growth properties of a pedicled iliac crest, transplanted as an iland flap on the extraarticular acetabular roof. This new surgical technique can be proposed for the care of difficult dysplastic hips in children.

Acetabulum↗

An active intervention on flap vasculature: flap prefabrication by pedicle implantation, delay, pre-expansion, pre-grafting, tissue engineering, biomaterials and perforators surgery.

The technology of flap prefabrications is a new, powerful tool in plastic and reconstructive surgery. It is based on an old idea, while applying the latest innovations in surgery. It involves any modification of a surgical flap done before its transfer to the final donor site, including surgical delay, pre-expansion, pre-grafting, the use of tissue engineering, biomaterials and perforators surgery, or the creation of a new pedicle by staged transfer of a vascular bundle. The different possibilities are discussed, with special reference to their biologic basis.

Animals↗

[Treatment of high-voltage electric injuries of the hand and forearm].

Electric injuries produce deep tissue destruction and in a large number of cases involve the forearm, entering from the hand. The authors report their experience, consisting of 13 cases, with satisfying results, particularly in relation to limb salvage. Salvage procedures, avoiding the amputation and including venous grafts and use of flaps, among which the inguinal flap is mostly used, are considered. Late necrosis occurring under grafted tissues often requires further surgery, including tendon and nerve grafts and scar revisions with skin grafts or flaps.

Adolescent↗