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Biomedical subjects

L T Yam

Publications and source records attributed to L T Yam.

At least 145 records · Page 8Linked to original sources
PubMed1972

Ultrastructural cytochemical demonstration of tartrate-resistant acid phosphatase isoenzyme activity in "hairy cells" of leukemic reticuloendotheliosis.

The pathognomonic "hairy cell" of leukemic reticuloendotheliosis was studied for ultrastructural localization of tartrate-resistant acid phosphatase activity. The enzyme activity could not be demonstrated by Gomori's method, but it was readily demonstrated in the cytoplasmic vesicles and Golgi saccules of the hairy cell by substitution of naphthol AS-BI phosphoric acid for Na-beta-glycerophosphate of Gomori's medium. This apparent substrate specificity may be used as a marker for electron microscopic identification of the hairy cell, and may facilitate the study of histogenesis of leukemic reticuloendotheliosis.

Acid Phosphatase↗
PubMed1972

Ultrastructural characteristics of the "hairy cells" of leukemic reticuloendotheliosis.

The pathognomonic neoplastic reticulum cells, or "hairy cells" of leukemic reticuloendotheliosis from 6 patients were studied with the electron microscope. These cells demonstrated characteristic ultrastructural features which were distinctly different from those of lymphocytes, monocytes, or histiocytes. In 3 patients a distinctive ribosome-lamella complex was found. The biologic significance of this unusual cytoplasmic inclusion is still unknown. Its frequent presence in leukemic reticuloendotheliosis and its rarity in other neoplastic diseases suggest a substantial yet unexplained relationship between this complex and leukemic reticuloendotheliosis.

Bone Marrow Cells↗