The interaction of the lens and the vitreous. II. The influence of the vitreous on lens trauma, water and electrolyte balance and osmotic stress.
Explore the source record for details and available documents.
Animals↗
Biomedical subjects
L T Chylack
Publications and source records attributed to L T Chylack.
The interaction of the lens and the vitreous. I. The high glucose cataract in a lens-vitreous preparation.
Explore the source record for details and available documents.
Animals↗
Control of glycolysis in the lens.
Explore the source record for details and available documents.
Adenosine Diphosphate↗
Nature and distribution of two distinct forms of hexokinase within the mammalian lens.
Explore the source record for details and available documents.
Adipose Tissue↗
A biochemical evaluation of a cataract induced in a high-glucose medium.
Explore the source record for details and available documents.
Animals↗
Sugar metabolism in the crystalline lens.
Research on the sugar metabolism of the crystalline lens, past and preent, is reviewed. The chief energy source in the lens is the Embden-Meyerhof pathway; respiration and oxidative phosphorylation become more important as the lens ages. The function of the alpha-glycerophosphate cycle is not fully understood. The mechanisms involved in cataract formation, including those of hypoglycemic cataract and osmotic cataracts, are discussed. Sugar cataracts can be delayed or prevented with such aldose reductase inhibitors as flavonoids. By inhibiting aldose reductase, the formation and accumulation of sugar alcohols is stopped. This approach may be useful as a medical therapy for human diabetic senile cataracts.
Aldehyde Reductase↗