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Biomedical subjects

L T Chow

Publications and source records attributed to L T Chow.

176 records · Page 10Linked to original sources
PubMedDate not supplied

Long survival with metastatic clear cell sarcoma of the Achilles tendon.

Clear cell sarcoma of tendons and aponeuroses is a rare tumor with a predilection for the lower extremities, particularly the foot. Although it is claimed to have a poor prognostic outlook, it is sometimes characterized by a slow clinical course. The authors report a case with a prolonged survival period of 7 years--5 years in the presence of multiple lung metastases.

Achilles Tendon↗
PubMedDate not supplied

Angiomatoid malignant fibrous histiocytoma: report of an unusual case with highly aggressive clinical course.

The authors report a case of angiomatoid malignant fibrous histiocytoma (AMFH), affecting a 9-year-old girl, with a highly aggressive clinical course. The tumor, noticed by the patient as a painless nodule in the dorsum of her left foot for 12 months, recurred 8 months after initial excision, and despite wide local reexcision, metastasized 4 months later to the liver and lung, where it grew at an alarming rate, to the extent of occupying the entire left hemithorax in a period of 10 weeks and killed the patient 14 months after initial excision. Review of the literature showed that the culminated rates of recurrence, metastasis, and mortality for AMFH were 23.2%, 8.7%, and 4.3%, respectively, indicating that it is definitely a malignant neoplasm with a potentially fatal outcome.

Child↗
PubMedDate not supplied

Characterization of 64-, 123- and 182-base-pair exons in the mouse alpha 2(IV) collagen gene.

Genes encoding types I, II and III collagens (fibrillar collagens) contain many discrete-size exons, most of them 54 base pairs (bp) long, in addition to the 45-, 99-, 108- and 162-bp exons. It has been suggested that these collagen genes evolved from an ancestral coding unit of 54 bp. Type IV collagen is a specific component of basement membranes and contains two genetically distinct polypeptides, the alpha 1(IV) and alpha 2(IV) chains. It differs from the types I-III collagens in that it contains interruptions in the Gly-X-Y repeat sequence and does not form ordered fibrillar structures. We have isolated complementary DNA and genomic clones for the mouse alpha 2(IV) collagen chain and here characterize 64-, 123- and 182-bp exons in the Gly-X-Y coding domain of the gene. The data suggest that the alpha 2(IV) collagen gene may have evolved differently from those encoding the fibrillar collagens.

Animals↗
PubMedDate not supplied

Breast metastasis in adolescents with alveolar rhabdomyosarcoma of the extremities: report of two cases.

We describe two adolescent girls with alveolar rhabdomyosarcoma arising from extremities who developed bilateral breast metastasis in their clinical course. In both cases, there was widespread systemic disease at initial presentation. Although complete remission was achieved on the 25th week post-chemotherapy initiation, the first patient developed breast metastasis in addition to systemic recurrence on the 44th week and expired. For the second patient, breast metastasis was noted in addition to systemic disease at initial presentation. Aggressive chemotherapy with autologous transplant and radiotherapy were given in addition to bilateral subcutaneous total mastectomy. The patient remained in complete remission 3 months post-therapy. We postulate that adolescent females with alveolar rhabdomyosarcoma of the extremities have a high risk of developing breast metastasis in the pubertal period, and aggressive multidisciplinary treatment is indicated.

Adolescent↗
PubMedDate not supplied

Pulmonary sclerosing hemangioma. Report of a case with diagnosis by fine needle aspiration.

Sclerosing hemangioma is a rare but well-recognized benign lesion of the lung. We report a case of pulmonary sclerosing hemangioma correctly diagnosed by fine needle aspiration (FNA) cytology. The sharp and smooth contour of the discrete mass in the left lower zone of the chest roentgenogram raised the possibility of a benign lesion, including pulmonary sclerosing hemangioma. The characteristic "blood spaces" with surrounding regular, bland polygonal tumor cells in the FNA smears provided an essential clue to the diagnosis of sclerosing hemangioma. It was confirmed by Surecut biopsy of the lesion. The patient remained well one year after the investigation and was spared an unnecessary diagnostic thoracotomy. The cytologic features and differential diagnoses of pulmonary sclerosing hemangioma are discussed. Besides delineating the cytologic characteristics of pulmonary sclerosing hemangioma, this case illustrates the importance of a careful clinicopathologic correlation, which should be exercised by the cytopathologist in all instances.

Aged↗
PubMedDate not supplied

Fine needle aspiration cytodiagnosis of leiomyosarcoma of the renal pelvis. A case report with immunohistochemical study.

Leiomyosarcoma of the renal pelvis is extremely rare. We report one such case correctly diagnosed by ultrasound-guided fine needle aspiration cytology (FNAC). The FNAC smears showed a monotonous population of closely packed, spindled tumor cells arranged in interlacing bundles. Those cells possessed markedly pleomorphic, hyperchromatic, elongated nuclei and a moderate amount of eosinophilic, fibrillary cytoplasm. Fascicles of similar spindle tumor cells arranged in a whorled pattern were seen in the section of the cell block. Immunohistochemistry was performed on the sections of the cell block preparation, showing intensely positive cytoplasmic staining of the tumor cells for muscle-specific actin but negative staining for CAM 5.2, AE1/AE3, S-100 protein and HMB-45. This staining pattern of the tumor allows its differentiation from other primary sarcomas of the kidney, sarcomatoid renal cell carcinoma, peripheral nerve sheath tumor and renal angiomyolipoma. The extreme degree of nuclear pleomorphism and hyperchromatism is not to be expected in renal leiomyoma or the usual cases of mesoblastic nephroma. Besides delineating the FNAC features of leiomyosarcoma of the renal pelvis, the present case illustrates the value of using the cell block preparation in FNAC.

Actins↗
PubMedDate not supplied

Signet-ring cell melanoma mimicking adenocarcinoma. A case report.

The fine needle aspiration findings in a lymph node involved by signet-ring cell melanoma, a very rare variant of malignant melanoma, are reported. The patient had a history of superficial spreading melanoma of the right foot, treated 10 years earlier by below-the-knee amputation. He presented with a right groin mass. Fine needle aspiration of the mass yielded poorly cohesive, large cells with eccentric nuclei and abundant, eosinophilic cytoplasm; many of them exhibited a signet-ring appearance. Melanin pigments were identified in a small proportion of tumor cells, and a diagnosis of metastatic melanoma was made. The subsequent lymph node excision revealed a metastatic tumor composed of polygonal and signet-ring cells that were positive for S-100 protein and HMB-45 but not cytokeratin. Nearly all reported cases of signet-ring cell melanoma occurred as metastatic or recurrent disease. It is important not to mistake signet-ring cell melanoma for adenocarcinoma in aspiration cytology, and a constellation of clinical features and of histochemical and immunohistochemical findings enables a correct diagnosis to be reached.

Adenocarcinoma↗