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Biomedical subjects

L Strunin

Publications and source records attributed to L Strunin.

At least 109 records · Page 6Linked to original sources
PubMed1979

Sedation for outpatient conservative dentistry. A trial of pentazocine supplementation to diazepam and local analgesia techniques.

Pentazocine 30 mg. or 15 mg or a placebo, was administered randomly to forty-nine patients undergoing conservative dental treatment in combination with a local analgesic block and intravenous diazepam. Simple cardiorespiratory measurements were made throughout the treatment period. Patients in the 30 mg pentazocine group required some 6 mg diazepam less than the placebo (control) group (P less than 0.05). Patients receiving 15 mg pentazocine also required less diazepam compared to the control group, but this difference was not statistically significant. There were no significant differences between the three groups either in recovery times or the cardiorespiratory measurements.

Adolescent↗
PubMed1977

Anaesthetic waste gas scavenging systems.

The Department of Health and Social Security has recently recommended that waste anaesthetic scavenging systems should be installed to reduce pollution in operating theatres. Three passive and two active systems were compared to see how effectively they reduced concentrations of halothane in the atmosphere. All five systems reduced halothane levels significantly, the combination of an active system and semiclosed circuitry being the most effective. All obvious leaks from equipment were controlled in this study, but normally such leaks contribute significantly to atmospheric pollution. Some of the benefits of a scavenging system may be lost if gases can still escape through leaks.

Air Conditioning↗
PubMed1977

Metabolism of 14C-labelled alphaxalone in man.

The metabolism of 14C-labelled alphaxalone, dispensed as Althesin, was studied in normal patients, patients with obstructive jaundice and patients with chronic renal disease and anuria. The radioactive label was removed rapidly from the plasma following i.v. administration. The major portion of the label was excreted in the urine. In patients with normal renal function 14C-labelled alphaxalone is probably taken up by the liver, metabolized to a more polar compound and excreted in the urine; a small amount is excreted in the bile. In the patient with anuria, hepatic uptake appears to be relatively normal and the length of action of Althesin is not prolonged. It is assumed that in such patients the eventual route of excretion is via the bile and faeces.

Alfaxalone Alfadolone Mixture↗
PubMed1977

Conditions for tracheal intubation following fazadinium and pancuronium.

Intubating conditions were studied in two groups of patients who received either fazadinium 1 mg/kg or pancuronium 0.1 mg/kg (group 1), or either fazadinium 0.5 mg/kg or pancuronium 0.08 mg/kg (group 2). In group 1 intubating conditions were studied at 30, 45, 60 and 75 s after injection of the relaxant drug, and in group 2 at 60 s after injection. Fazadinium provided better intubating conditions than pancuronium during the first 60 s after administration in group 1 (P less than 0.01). In group 2 there was no significant difference between the conditions provided by the two drugs.

Humans↗
PubMed1977

Enflurane (Ethrane) anaesthesia in man. Metabolism and effects on biochemical and haematological variables.

In 10 patients serum inorganic fluoride increased to a mean peak value of 16 micronmol.litre--1 after 2 h of enflurane anaesthesia. Four days after anaesthesia, serum inorganic fluoride had decreased to the values before operation. The maximum daily inorganic fluoride excretion in urine (UFV) did not exceed 200 micronmol.litre--1. In a group of 20 patients routine biochemical and haematological variables were measured before and after enflurane anaesthesia. There were only minor changes in these variables, attributable to the surgical procedure. It is concluded that renal dysfunction is unlikely to follow enflurane anaesthesia in patients with previously normal hepatic and renal function.

Anesthesia, Inhalation↗
PubMed1977

Acute liver failure. Experience in a special unit.

Acute liver failure involves disturbances of all major organ systems. The pathophysiology of these disturbances are reviewed and details of management for each system is discussed in clinical work in a special Liver Failure Unit is used to derive principles of treatment, and the use of extracorporeal charcoal haemoperfusion is outlined.

Acid-Base Imbalance↗
PubMed1977

Anaesthesia for the neonatal pig--'the micropig'.

The use of spontaneous respiration of oxygen, nitrous oxide, and halothane via Jackson Rees's modification of Ayre's T-piece and a flexible 'snout' mask proved to be a simple and effective way of anaesthetizing neonatal pigs--'micropigs'--in the first few days of life without resorting to endotracheal intubation. No airway obstruction occurred as long as the head was extended with firm traction on the jaw and provided the nostrils were not pressed up against the wall of the mask. The anaesthetic technique described provided adequate muscle relaxation and analgesia for extensive abdominal surgery. The animals recovered rapidly and there were no postoperative complications.

Anesthesia, General↗
PubMed1976

Unexplained hepatitis following halothane.

Full clinical and laboratory details of 203 patients with postoperative jaundice were submitted to a panel of hepatologists. All patients whose jaundice may have had an identifiable cause were excluded, which left 76 patients with unexplained hepatitis following halothane anaesthesia (UHFH). Hepatitis in 95% of these cases followed multiple exposure to halothane, with repeated exposure within four weeks in 55% of cases. Twenty-nine patients were obese, 52 were aged 41-70, and 53 were women. Thirteen patients died in acute hepatic failure. Rapid onset of jaundice after anaesthesia, male sex, and obesity in either sex were poor prognostic signs. Of the clinical stigmata of hypersensitivity, only eosinophilia was impressive. The UHFH group had a much greater incidence of liver kidney microsomal (LKM) and thyroid antibodies and autoimmune complement fixation than those patients whose jaundice related to identifiable factors. Thirteen of the 19 patients with LKM antibodies also had thyroid antibodies. In six patients retested two to three years later LKM antibodies had disappeared, although thyroid antibodies persisted. Rapidly repeated exposure to halothane may cause hepatitis, but such a complication is probably rare. Possibly obese women with a tendency to organ-specific autoimmunity may be more at risk. Nevertheless, the comparative risks of rapidly repeated halothane or non-halothane anaesthesia cannot be determined from the present data. If alternative satisfactory agents are available halothane should be avoided in patients with unexplained hepatitis after previous exposure, although in three to five patients with UHFH who were re-exposed to halothane jaundice did not recur.

Adolescent↗
PubMed1976

Anaesthesia for injection of bleeding oesophageal varices.

Patients with haemorrhage from oesophageal varices associated with portal hypertension are poor risks for anaesthesia and surgery. One method of controlling such haemorrhage is injection of the oesophageal varices (sclero-therapy) via an oesophagoscope. Careful preoperative preparation and use of the Sengstaken-Blakemore tube in combination with the anaesthetic technique of intermittent Althesin and suxamethonium with artificial ventilation with nitrous oxide and oxygen enables sclerotherapy to be carried out successfully.

Alfaxalone Alfadolone Mixture↗